Publications by authors named "Judith Varner"

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PI3Kγ in Tumour Inflammation: Bridging Immune Response and Cancer Progression-A Mini-Review.
Anghesom Ghebremedhin, Judith A Varner

Immunology· October 2025

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Positive and negative roles of myeloid cells in cancer immunotherapy.
Jaroslav Zak, Judith A Varner

J Immunother Cancer· October 2025

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Targeting myeloid cells to improve cancer immune therapy.
Hui Chen, Zihan Xu, Judith Varner

Front Immunol· August 2025

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One Step Ahead: Preventing Tumor Adaptation to Immune Therapy.
Erica L Braverman, Giuliana P Mognol, Andy J Minn, Dario A A Vignali, Judith A Varner

Am Soc Clin Oncol Educ Book· June 2025

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Targeting PI3Kγ in cancer.
Giuliana P Mognol, Anghesom Ghebremedhin, Judith A Varner

Trends Cancer· May 2025

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The Role of PI3k-Gamma Modulation in Bacterial Infection: A Review of the Literature and Selected Experimental Observations.
Daniel Sun, Alexandria Hoffman, Fatemeh Askarian, Elisabet Bjånes, Eric X Lin, Judith Varner

Antibiotics (Basel)· March 2025

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Virus nanotechnology for intratumoural immunotherapy.
Anthony O Omole, Zhongchao Zhao, Sabrina Chang-Liao, Jessica Fernanda Affonso de Oliveira, Christine E Boone, Judith Varner

Nat Rev Bioeng· November 2024

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Eganelisib combined with immune checkpoint inhibitor therapy and chemotherapy in frontline metastatic triple-negative breast cancer triggers macrophage reprogramming, immune activation and extracellular matrix reorganization in the tumor microenvironment.
Brenda C O'Connell, Charley Hubbard, Nora Zizlsperger, Donna Fitzgerald, Jeffrey L Kutok, Judith Varner

J Immunother Cancer· August 2024

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PI3Kγ inhibition circumvents inflammation and vascular leak in SARS-CoV-2 and other infections.
Ryan M Shepard, Anghesom Ghebremedhin, Isaraphorn Pratumchai, Sally R Robinson, Courtney Betts, Judith A Varner

Sci Transl Med· July 2024

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PI3Kγ inhibition combined with DNA vaccination unleashes a B-cell-dependent antitumor immunity that hampers pancreatic cancer.
Claudia Curcio, Gianluca Mucciolo, Cecilia Roux, Silvia Brugiapaglia, Alessandro Scagliotti, Judith A Varner

J Exp Clin Cancer Res· June 2024

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JAK inhibition enhances checkpoint blockade immunotherapy in patients with Hodgkin lymphoma.
Jaroslav Zak, Isaraphorn Pratumchai, Brett S Marro, Kristi L Marquardt, Reza Beheshti Zavareh, Judith A Varner

Science· June 2024

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PI3Kγ maintains the self-renewal of acute myeloid leukemia stem cells by regulating the pentose phosphate pathway.
Hao Gu, Chiqi Chen, Zhi-Shuai Hou, Xia-Di He, Shaozhen Xie, Judith A Varner

Blood· May 2024

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Enzyme lights dual fires to promote cancer.
Anghesom Ghebremedhin, Judith A Varner

Nature· May 2023

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PI3Kγ stimulates a high molecular weight form of myosin light chain kinase to promote myeloid cell adhesion and tumor inflammation.
Michael C Schmid, Sang Won Kang, Hui Chen, Marc Paradise, Anghesom Ghebremedhin, Judith A Varner

Nat Commun· April 2022

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PI3Kγ inhibition suppresses microglia/TAM accumulation in glioblastoma microenvironment to promote exceptional temozolomide response.
Jie Li, Megan M Kaneda, Jun Ma, Ming Li, Ryan M Shepard, Judith A Varner

Proc Natl Acad Sci U S A· April 2021

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Arming Tumor-Associated Macrophages to Reverse Epithelial Cancer Progression.
Hiromi I Wettersten, Sara M Weis, Paulina Pathria, Tami Von Schalscha, Toshiyuki Minami, Judith A Varner

Cancer Res· October 2019

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Securing the Payload, Finding the Cell, and Avoiding the Endosome: Peptide-Targeted, Fusogenic Porous Silicon Nanoparticles for Delivery of siRNA.
Byungji Kim, Si Sun, Judith A Varner, Stephen B Howell, Erkki Ruoslahti

Adv Mater· August 2019

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MST1R kinase accelerates pancreatic cancer progression via effects on both epithelial cells and macrophages.
Michele L Babicky, Megan M Harper, Jeffery Chakedis, Alex Cazes, Evangeline S Mose, Judith A Varner

Oncogene· July 2019

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Targeting Tumor-Associated Macrophages in Cancer.
Paulina Pathria, Tiani L Louis, Judith A Varner

Trends Immunol· April 2019

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Integrin CD11b activation drives anti-tumor innate immunity.
Michael C Schmid, Samia Q Khan, Megan M Kaneda, Paulina Pathria, Ryan Shepard, Judith A Varner

Nat Commun· December 2018

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PI3Kγ Activates Integrin α and Promotes Immune Suppressive Myeloid Cell Polarization during Tumor Progression.
Philippe Foubert, Megan M Kaneda, Judith A Varner

Cancer Immunol Res· November 2017

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Combination immunotherapy with TLR agonists and checkpoint inhibitors suppresses head and neck cancer.
Fumi Sato-Kaneko, Shiyin Yao, Alast Ahmadi, Shannon S Zhang, Tadashi Hosoya, Judith A Varner

JCI Insight· September 2017

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Corrigendum: PI3Kγ is a molecular switch that controls immune suppression.
Megan M Kaneda, Karen S Messer, Natacha Ralainirina, Hongying Li, Christopher J Leem, Judith A Varner

Nature· February 2017

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PI3Kγ is a molecular switch that controls immune suppression.
Megan M Kaneda, Karen S Messer, Natacha Ralainirina, Hongying Li, Christopher J Leem, Judith A Varner

Nature· November 2016

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Macrophage PI3Kγ Drives Pancreatic Ductal Adenocarcinoma Progression.
Megan M Kaneda, Paola Cappello, Abraham V Nguyen, Natacha Ralainirina, Chanae R Hardamon, Judith A Varner

Cancer Discov· August 2016

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