Publications by authors named "Julien Beyrath"

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Sonlicromanol's active metabolite KH176m normalizes prostate cancer stem cell mPGES-1 overexpression and inhibits cancer spheroid growth.
Xiaolan Jiang, Herma Renkema, Jan Smeitink, Julien Beyrath

PLoS One· July 2024

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Sonlicromanol improves neuronal network dysfunction and transcriptome changes linked to m.3243A>G heteroplasmy in iPSC-derived neurons.
Teun M Klein Gunnewiek, Anouk H A Verboven, Iris Pelgrim, Mark Hogeweg, Chantal Schoenmaker, Julien Beyrath

Stem Cell Reports· September 2021

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Stimulation of cholesterol biosynthesis in mitochondrial complex I-deficiency lowers reductive stress and improves motor function and survival in mice.
Tom J J Schirris, Sergio Rossell, Ria de Haas, Sanne J C M Frambach, Charlotte A Hoogstraten, Julien D Beyrath

Biochim Biophys Acta Mol Basis Dis· April 2021

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Oxidative switch drives mitophagy defects in dopaminergic parkin mutant patient neurons.
Aurelie Schwartzentruber, Camilla Boschian, Fernanda Martins Lopes, Monika A Myszczynska, Elizabeth J New, Julien Beyrath

Sci Rep· September 2020

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SK channel-mediated metabolic escape to glycolysis inhibits ferroptosis and supports stress resistance in C. elegans.
Inge E Krabbendam, Birgit Honrath, Benjamin Dilberger, Eligio F Iannetti, Robyn S Branicky, Julien Beyrath

Cell Death Dis· April 2020

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Live-Imaging Readouts and Cell Models for Phenotypic Profiling of Mitochondrial Function.
Eligio F Iannetti, Alessandro Prigione, Jan A M Smeitink, Werner J H Koopman, Julien Beyrath

Front Genet· March 2019

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A Mitochondrial Complex I Deficiency Phenotype Array.
Sarah Foriel, G Herma Renkema, Yvonne Lasarzewski, Job Berkhout, Richard J Rodenburg, Julien Beyrath

Front Genet· March 2019

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Mitochondrial Migraine: Disentangling the angiopathy paradigm in m.3243A>G patients.
Jan Smeitink, Saskia Koene, Julien Beyrath, Christiaan Saris, Douglas Turnbull

JIMD Rep· March 2019

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The KHENERGY Study: Safety and Efficacy of KH176 in Mitochondrial m.3243A>G Spectrum Disorders.
Mirian C H Janssen, Saskia Koene, Paul de Laat, Pleun Hemelaar, Peter Pickkers, Julien Beyrath

Clin Pharmacol Ther· January 2019

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Rescue from galactose-induced death of Leigh Syndrome patient cells by pyruvate and NAD.
Eligio F Iannetti, Jan A M Smeitink, Peter H G M Willems, Julien Beyrath, Werner J H Koopman

Cell Death Dis· November 2018

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KH176 Safeguards Mitochondrial Diseased Cells from Redox Stress-Induced Cell Death by Interacting with the Thioredoxin System/Peroxiredoxin Enzyme Machinery.
Julien Beyrath, Mina Pellegrini, Herma Renkema, Lisanne Houben, Svetlana Pecheritsyna

Sci Rep· April 2018

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Feeding difficulties, a key feature of the NDUFS4 mitochondrial disease model.
Sarah Foriel, Julien Beyrath, Ilse Eidhof, Richard J Rodenburg, Annette Schenck

Dis Model Mech· March 2018

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KH176 under development for rare mitochondrial disease: a first in man randomized controlled clinical trial in healthy male volunteers.
Saskia Koene, Edwin Spaans, Luc Van Bortel, Griet Van Lancker, Brant Delafontaine, Julien Beyrath

Orphanet J Rare Dis· October 2017

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Therapeutic effects of the mitochondrial ROS-redox modulator KH176 in a mammalian model of Leigh Disease.
Ria de Haas, Devashish Das, Alejandro Garanto, Herma G Renkema, Rick Greupink, Julien Beyrath

Sci Rep· September 2017

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Hetero-oligomerization between the TNF receptor superfamily members CD40, Fas and TRAILR2 modulate CD40 signalling.
Cristian R Smulski, Marion Decossas, Neila Chekkat, Julien Beyrath, Laure Willen

Cell Death Dis· February 2017

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Synthetic ligands of death receptor 5 display a cell-selective agonistic effect at different oligomerization levels.
Julien Beyrath, Neila Chekkat, Cristian R Smulski, Caterina M Lombardo, Marie-Charlotte Lechner

Oncotarget· October 2016

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Multiplexed high-content analysis of mitochondrial morphofunction using live-cell microscopy.
Eligio F Iannetti, Jan A M Smeitink, Julien Beyrath, Peter H G M Willems, Werner J H Koopman

Nat Protoc· September 2016

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Mitochondrial disorders in children: toward development of small-molecule treatment strategies.
Werner Jh Koopman, Julien Beyrath, Cheuk-Wing Fung, Saskia Koene, Richard J Rodenburg

EMBO Mol Med· April 2016

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Statin-Induced Myopathy Is Associated with Mitochondrial Complex III Inhibition.
Tom J J Schirris, G Herma Renkema, Tina Ritschel, Nicol C Voermans, Albert Bilos, Julien D Beyrath

Cell Metab· September 2015

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Mitochondrial diseases: Drosophila melanogaster as a model to evaluate potential therapeutics.
Sarah Foriel, Peter Willems, Jan Smeitink, Annette Schenck, Julien Beyrath

Int J Biochem Cell Biol· June 2015

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Toward high-content screening of mitochondrial morphology and membrane potential in living cells.
Eligio F Iannetti, Peter H G M Willems, Mina Pellegrini, Julien Beyrath, Jan A M Smeitink

Int J Biochem Cell Biol· June 2015

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Quantifying small molecule phenotypic effects using mitochondrial morpho-functional fingerprinting and machine learning.
Lionel Blanchet, Jan A M Smeitink, Sjenet E van Emst-de Vries, Caroline Vogels, Mina Pellegrini, Julien Beyrath

Sci Rep· January 2015

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Multidrug resistance protein 4/ ATP binding cassette transporter 4: a new potential therapeutic target for acute myeloid leukemia.
Sabrina Copsel, Ariana Bruzzone, Maria May, Julien Beyrath, Victoria Wargon

Oncotarget· October 2014

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Cysteine-rich domain 1 of CD40 mediates receptor self-assembly.
Cristian R Smulski, Julien Beyrath, Marion Decossas, Neila Chekkat, Philippe Wolff

J Biol Chem· April 2013

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Antitumor activity of liposomal ErbB2/HER2 epitope peptide-based vaccine constructs incorporating TLR agonists and mannose receptor targeting.
Jean-Sébastien Thomann, Béatrice Heurtault, Steffen Weidner, Mélanie Brayé, Julien Beyrath

Biomaterials· July 2011

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