Publications by authors named "Julio Scharfstein"

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impairs CX3CL1/fractalkine shedding from mouse cortical neurons, leading to microglia activation.
Leonardo Leal de Castro, Barbara Gomes da Rosa, Maria Carolina Peixoto-Rodrigues, Amanda Roberta Revoredo Vicentino, Vanderlei da Silva Fraga-Junior, Julio Scharfstein

Microbiol Spectr· October 2025

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(Golden Syrian Hamster) Experimental Model of SARS-CoV-2 Infection Reveals That Lung Injury Is Associated with Phenotypic Differences Between SARS-CoV-2 Variants.
Daniela Del Rosario Flores Rodrigues, Alexandre Dos Santos da Silva, Arthur Daniel Rocha Alves, Bárbara Araujo Rossi, Richard de Almeida Lima, Julio Scharfstein

Viruses· July 2025

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SARS-Cov-2 Replication in a Blood-Brain Barrier Model Established with Human Brain Microvascular Endothelial Cells Induces Permeability and Disables ACE2-Dependent Regulation of Bradykinin B1 Receptor.
Sharton Vinicius Antunes Coelho, Gabriela Lisboa E Souza, Bruno Braz Bezerra, Luan Rocha Lima, Isadora Alonso Correa, Julio Scharfstein

Int J Mol Sci· June 2025

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Protective effect of Chromobacterium violaceum and violacein against bone resorption by periodontitis.
Davi da Silva Barbirato, Mariana Fampa Fogacci, Taísa Coelho Guimarães, Denise Pires de Carvalho, Janine Cardoso Rurr, Julio Scharfstein

Clin Oral Investig· May 2023

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High mobility group box 1, ATP, lipid mediators, and tissue factor are elevated in COVID-19 patients: HMGB1 as a biomarker of worst prognosis.
Amanda Roberta Revoredo Vicentino, Vanderlei da Silva Fraga-Junior, Matheus Palazzo, Natalia Recardo Amorim Tasmo, Danielle A S Rodrigues, Julio Scharfstein

Clin Transl Sci· April 2023

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Genetic Ablation and Pharmacological Blockade of Bradykinin B1 Receptor Unveiled a Detrimental Role for the Kinin System in Chagas Disease Cardiomyopathy.
Ana Carolina Oliveira, Amanda Roberta Revoredo Vicentino, Daniele Andrade, Isabela Resende Pereira, Leonardo Saboia-Vahia, Julio Scharfstein

J Clin Med· April 2023

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Pleiotropic antifibrotic actions of aspirin-triggered resolvin D1 in the lungs.
Rafael F Guilherme, José Bruno N F Silva, Ingrid Waclawiack, Vanderlei S Fraga-Junior, Thaís O Nogueira, Júlio Scharfstein

Front Immunol· March 2023

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Brazilian immunology in Caxambu: beyond vaccination, a tribute to the pioneers of basic research in Chagas disease.
Julio Scharfstein

Mem Inst Oswaldo Cruz· May 2022

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Sheltered in Stromal Tissue Cells, Orchestrates Inflammatory Neovascularization via Activation of the Mast Cell Chymase Pathway.
Lucas Vellasco, Erik Svensjö, Carlos Alberto Bulant, Pablo Javier Blanco, Fábio Nogueira, Julio Scharfstein

Pathogens· January 2022

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Surface megalin expression is a target to the inhibitory effect of bradykinin on the renal albumin endocytosis.
Sarah A S Alves, Lucas S Florentino, Douglas E Teixeira, Rodrigo P Silva-Aguiar, Diogo B Peruchetti, Julio Scharfstein

Peptides· December 2021

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Dietary Fiber Drives IL-1β-Dependent Peritonitis Induced by via Activation of the NLRP3 Inflammasome.
Bruno Jennings-Almeida, Juliana P Castelpoggi, Erivan S Ramos-Junior, Eliane de Oliveira Ferreira, Regina M C P Domingues, Julio Scharfstein

J Immunol· May 2021

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P2Y14 Receptor as a Target for Neutrophilia Attenuation in Severe COVID-19 Cases: From Hematopoietic Stem Cell Recruitment and Chemotaxis to Thrombo-inflammation.
Lyvia Lintzmaier Petiz, Talita Glaser, Julio Scharfstein, Mariusz Z Ratajczak, Henning Ulrich

Stem Cell Rev Rep· February 2021

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Contact System Activation in Plasma from Dengue Patients Might Harness Endothelial Virus Replication through the Signaling of Bradykinin Receptors.
Sharton V A Coelho, Naiara M Rust, Lucas Vellasco, Michelle P Papa, Aline S G Pereira, Júlio Scharfstein

Pharmaceuticals (Basel)· January 2021

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IL-18R signaling is required for γδ T cell response and confers resistance to Trypanosoma cruzi infection.
Julia Barbalho da Mota, Juliana Echevarria-Lima, Fernanda Kyle-Cezar, Matheus Melo, Maria Bellio, Julio Scharfstein

J Leukoc Biol· October 2020

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Mast Cells in Alveolar Septa of COVID-19 Patients: A Pathogenic Pathway That May Link Interstitial Edema to Immunothrombosis.
Jarbas da Silva Motta Junior, Anna Flavia Ribeiro Dos Santos Miggiolaro, Seigo Nagashima, Caroline Busatta Vaz de Paula, Cristina Pellegrino Baena, Julio Scharfstein

Front Immunol· October 2020

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Kinins Released by Erythrocytic Stages of Enhance Adhesion of Infected Erythrocytes to Endothelial Cells and Increase Blood Brain Barrier Permeability via Activation of Bradykinin Receptors.
Leandro S Silva, Alessandro S Pinheiro, Douglas E Teixeira, Rodrigo P Silva-Aguiar, Diogo B Peruchetti, Julio Scharfstein

Front Med (Lausanne)· April 2019

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P2X7 receptor-mediated leukocyte recruitment and Porphyromonas gingivalis clearance requires IL-1β production and autocrine IL-1 receptor activation.
Cássio Luiz Coutinho Almeida-da-Silva, Erivan S Ramos-Junior, Ana Carolina Morandini, Gabrielle da Costa Rocha, Ygor Marinho, Julio Scharfstein

Immunobiology· January 2019

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Subverting bradykinin-evoked inflammation by co-opting the contact system: lessons from survival strategies of Trypanosoma cruzi.
Julio Scharfstein

Curr Opin Hematol· September 2018

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Oral infection of mice with Fusobacterium nucleatum results in macrophage recruitment to the dental pulp and bone resorption.
Larry Johnson, Cássio Luiz Coutinho Almeida-da-Silva, Christina Maeda Takiya, Vanessa Figliuolo, Gustavo Miranda Rocha, Julio Scharfstein

Biomed J· June 2018

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G Protein-Coupled Kinin Receptors and Immunity Against Pathogens.
Julio Scharfstein, Pablo I P Ramos, Manoel Barral-Netto

Adv Immunol· May 2018

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Mast Cell Coupling to the Kallikrein-Kinin System Fuels Intracardiac Parasitism and Worsens Heart Pathology in Experimental Chagas Disease.
Clarissa R Nascimento, Daniele Andrade, Carla Eponina Carvalho-Pinto, Rafaela Rangel Serra, Lucas Vellasco, Julio Scharfstein

Front Immunol· August 2017

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Computer-aided quantification of microvascular networks: Application to alterations due to pathological angiogenesis in the hamster.
Carlos A Bulant, Pablo J Blanco, Lucas O Müller, Julio Scharfstein, Erik Svensjö

Microvasc Res· July 2017

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Porphyromonas gingivalis fimbriae dampen P2X7-dependent interleukin-1β secretion.
Ana Carolina Morandini, Erivan S Ramos-Junior, Jan Potempa, Ky-Anh Nguyen, Ana Carolina Oliveira, Julio Scharfstein

J Innate Immun· June 2015

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Ecotin-like ISP of L. major promastigotes fine-tunes macrophage phagocytosis by limiting the pericellular release of bradykinin from surface-bound kininogens: a survival strategy based on the silencing of proinflammatory G-protein coupled kinin B2 and B1 receptors.
Erik Svensjö, Larissa Nogueira de Almeida, Lucas Vellasco, Luiz Juliano, Julio Scharfstein

Mediators Inflamm· June 2015

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C5a and bradykinin receptor cross-talk regulates innate and adaptive immunity in Trypanosoma cruzi infection.
Veronica Schmitz, Larissa Nogueira Almeida, Erik Svensjö, Ana Carolina Monteiro, Jörg Köhl, Julio Scharfstein

J Immunol· October 2014

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