Publications by authors named "Jun Hamazaki"

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Proteasomal regulation of ASK family kinases dictates cell fate under hyperosmotic stress.
Xiangyu Zhou, Kengo Watanabe, Kazuhiro Morishita, Jun Hamazaki, Shigeo Murata

J Biol Chem· September 2025

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The DYT6 dystonia causative protein THAP1 is responsible for proteasome activity via PSMB5 transcriptional regulation.
Yan Wang, Yi Wang, Tomohiro Iriki, Eiichi Hashimoto, Maki Inami, Jun Hamazaki

Nat Commun· February 2025

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Intrinsic signaling pathways modulate targeted protein degradation.
Yuki Mori, Yoshino Akizuki, Rikuto Honda, Miyu Takao, Ayaka Tsuchimoto, Jun Hamazaki

Nat Commun· July 2024

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Relationships between protein degradation, cellular senescence, and organismal aging.
Jun Hamazaki, Shigeo Murata

J Biochem· April 2024

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Senescent cells form nuclear foci that contain the 26S proteasome.
Tomohiro Iriki, Hiroaki Iio, Shu Yasuda, Shun Masuta, Masakazu Kato, Jun Hamazaki

Cell Rep· August 2023

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PAC1 Deficiency Protects Obese Male Mice From Immobilization-Induced Muscle Atrophy by Suppressing FoxO-Atrogene Axis.
Qifang Li, Kiyo-Aki Ishii, Kyoko Kamoshita, Kenta Takahashi, Halimulati Abuduwaili, Jun Hamazaki

Endocrinology· April 2023

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Heterozygous missense variant of the proteasome subunit β-type 9 causes neonatal-onset autoinflammation and immunodeficiency.
Nobuo Kanazawa, Hiroaki Hemmi, Noriko Kinjo, Hidenori Ohnishi, Jun Hamazaki

Nat Commun· November 2021

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Enhanced O-GlcNAcylation Mediates Cytoprotection under Proteasome Impairment by Promoting Proteasome Turnover in Cancer Cells.
Eiichi Hashimoto, Shota Okuno, Shoshiro Hirayama, Yoshiyuki Arata, Tsuyoshi Goto, Jun Hamazaki

iScience· July 2020

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ER-Resident Transcription Factor Nrf1 Regulates Proteasome Expression and Beyond.
Jun Hamazaki, Shigeo Murata

Int J Mol Sci· May 2020

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NRF3-POMP-20S Proteasome Assembly Axis Promotes Cancer Development via Ubiquitin-Independent Proteolysis of p53 and Retinoblastoma Protein.
Tsuyoshi Waku, Nanami Nakamura, Misaki Koji, Hidenori Watanabe, Hiroki Katoh, Jun Hamazaki

Mol Cell Biol· April 2020

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Defective induction of the proteasome associated with T-cell receptor signaling underlies T-cell senescence.
Yoshiyuki Arata, Ayaka Watanabe, Ryo Motosugi, Ryuichi Murakami, Tsuyoshi Goto, Jun Hamazaki

Genes Cells· December 2019

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Trans-omics Impact of Thymoproteasome in Cortical Thymic Epithelial Cells.
Izumi Ohigashi, Yu Tanaka, Kenta Kondo, Sayumi Fujimori, Hiroyuki Kondo, Jun Hamazaki

Cell Rep· November 2019

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FAM48A mediates compensatory autophagy induced by proteasome impairment.
Yoshiyuki Arata, Ayaka Watanabe, Ryo Motosugi, Shun-Ichiro Iemura, Tohru Natsume, Jun Hamazaki

Genes Cells· August 2019

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Shigella effector IpaH4.5 targets 19S regulatory particle subunit RPN13 in the 26S proteasome to dampen cytotoxic T lymphocyte activation.
Ryota Otsubo, Hitomi Mimuro, Hiroshi Ashida, Jun Hamazaki, Shigeo Murata

Cell Microbiol· March 2019

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Specific Modification of Aged Proteasomes Revealed by Tag-Exchangeable Knock-In Mice.
Takuya Tomita, Shoshiro Hirayama, Yasuyuki Sakurai, Yuki Ohte, Hidehito Yoshihara, Jun Hamazaki

Mol Cell Biol· January 2019

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PAC1-PAC2 proteasome assembly chaperone retains the core α4-α7 assembly intermediates in the cytoplasm.
Wei Wu, Kazutaka Sahara, Shoshiro Hirayama, Xian Zhao, Ayaka Watanabe, Jun Hamazaki

Genes Cells· October 2018

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Transcriptional regulation of the 26S proteasome by Nrf1.
Shun Koizumi, Jun Hamazaki, Shigeo Murata

Proc Jpn Acad Ser B Phys Biol Sci· October 2018

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Ubiquitin-Binding Protein CG5445 Suppresses Aggregation and Cytotoxicity of Amyotrophic Lateral Sclerosis-Linked TDP-43 in Drosophila.
Hiroyuki Uechi, Erina Kuranaga, Tomohiro Iriki, Kohei Takano, Shoshiro Hirayama, Jun Hamazaki

Mol Cell Biol· February 2018

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Early and consistent overexpression of ADRM1 in ovarian high-grade serous carcinoma.
Rosie T Jiang, Anna Yemelyanova, Deyin Xing, Ravi K Anchoori, Jun Hamazaki

J Ovarian Res· August 2017

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Structure of the Rpn13-Rpn2 complex provides insights for Rpn13 and Uch37 as anticancer targets.
Xiuxiu Lu, Urszula Nowicka, Vinidhra Sridharan, Fen Liu, Leah Randles, Jun Hamazaki

Nat Commun· June 2017

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Foxn1-β5t transcriptional axis controls CD8 T-cell production in the thymus.
Muhammad Myn Uddin, Izumi Ohigashi, Ryo Motosugi, Tomomi Nakayama, Mie Sakata, Jun Hamazaki

Nat Commun· February 2017

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The aspartyl protease DDI2 activates Nrf1 to compensate for proteasome dysfunction.
Shun Koizumi, Taro Irie, Shoshiro Hirayama, Yasuyuki Sakurai, Hideki Yashiroda, Jun Hamazaki

Elife· August 2016

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Sirt1-deficiency causes defective protein quality control.
Takuya Tomita, Jun Hamazaki, Shoshiro Hirayama, Michael W McBurney, Hideki Yashiroda

Sci Rep· July 2015

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Redundant Roles of Rpn10 and Rpn13 in Recognition of Ubiquitinated Proteins and Cellular Homeostasis.
Jun Hamazaki, Shoshiro Hirayama, Shigeo Murata

PLoS Genet· July 2015

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Characterization of the testis-specific proteasome subunit α4s in mammals.
Hiroyuki Uechi, Jun Hamazaki, Shigeo Murata

J Biol Chem· May 2014

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