Publications by authors named "Jun Ohwada"

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Optimization of the phenylurea moiety in a phosphoinositide 3-kinase (PI3K) inhibitor to improve water solubility and the PK profile by introducing a solubilizing group and ortho substituents.
Hatsuo Kawada, Hirosato Ebiike, Masao Tsukazaki, Shun Yamamoto, Kohei Koyama, Jun Ohwada

Bioorg Med Chem· July 2016

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Modification of a dihydropyrrolopyrimidine phosphoinositide 3-kinase (PI3K) inhibitor to improve oral bioavailability.
Hatsuo Kawada, Hirosato Ebiike, Masao Tsukazaki, Shun Yamamoto, Kohei Koyama, Jun Ohwada

Bioorg Med Chem· December 2015

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Lead optimization of a dihydropyrrolopyrimidine inhibitor against phosphoinositide 3-kinase (PI3K) to improve the phenol glucuronic acid conjugation.
Hatsuo Kawada, Hirosato Ebiike, Masao Tsukazaki, Mitsuaki Nakamura, Kenji Morikami, Jun Ohwada

Bioorg Med Chem Lett· February 2013

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Design and evaluation of azaindole-substituted N-hydroxypyridones as glyoxalase I inhibitors.
Takashi Chiba, Jun Ohwada, Hiroshi Sakamoto, Takamitsu Kobayashi, Takaaki A Fukami

Bioorg Med Chem Lett· December 2012

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Design and synthesis of a highly selective, orally active and potent anaplastic lymphoma kinase inhibitor (CH5424802).
Kazutomo Kinoshita, Kohsuke Asoh, Noriyuki Furuichi, Toshiya Ito, Hatsuo Kawada, Jun Ohwada

Bioorg Med Chem· February 2012

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9-substituted 6,6-dimethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazoles as highly selective and potent anaplastic lymphoma kinase inhibitors.
Kazutomo Kinoshita, Takamitsu Kobayashi, Kohsuke Asoh, Noriyuki Furuichi, Toshiya Ito, Jun Ohwada

J Med Chem· September 2011

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The selective class I PI3K inhibitor CH5132799 targets human cancers harboring oncogenic PIK3CA mutations.
Hiroshi Tanaka, Miyuki Yoshida, Hiromi Tanimura, Toshihiko Fujii, Kiyoaki Sakata, Jun Ohwada

Clin Cancer Res· May 2011

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Discovery and biological activity of a novel class I PI3K inhibitor, CH5132799.
Jun Ohwada, Hirosato Ebiike, Hatsuo Kawada, Masao Tsukazaki, Mitsuaki Nakamura

Bioorg Med Chem Lett· March 2011

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In vitro activity of isavuconazole against 140 reference fungal strains and 165 clinically isolated yeasts from Japan.
Toshikazu Yamazaki, Yukiko Inagaki, Toshihiko Fujii, Jun Ohwada, Masao Tsukazaki

Int J Antimicrob Agents· October 2010

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A water soluble prodrug of a novel camptothecin analog is efficacious against breast cancer resistance protein-expressing tumor xenografts.
Mika Endo, Masanori Miwa, Masako Ura, Hiromi Tanimura, Kenji Taniguchi, Jun Ohwada

Cancer Chemother Pharmacol· January 2010

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Synthesis and biological activities of a pH-dependently activated water-soluble prodrug of a novel hexacyclic camptothecin analog.
Jun Ohwada, Sawako Ozawa, Masami Kohchi, Hiroshi Fukuda, Chikako Murasaki

Bioorg Med Chem Lett· May 2009

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Synthesis of new camptothecin analogs with improved antitumor activities.
Satoshi Niizuma, Masao Tsukazaki, Hitomi Suda, Takeshi Murata, Jun Ohwada

Bioorg Med Chem Lett· April 2009

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Design, synthesis and antifungal activity of a novel water soluble prodrug of antifungal triazole.
Jun Ohwada, Masao Tsukazaki, Tadakatsu Hayase, Nobuhiro Oikawa, Yoshiaki Isshiki

Bioorg Med Chem Lett· January 2003

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Synthesis of novel water soluble benzylazolium prodrugs of lipophilic azole antifungals.
Jun Ohwada, Chikako Murasaki, Toshikazu Yamazaki, Shigeyasu Ichihara, Isao Umeda

Bioorg Med Chem Lett· October 2002

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