Publications by authors named "Jun-Wan Shin"

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Significant underascertainment in Huntington's disease.
Sujin Lee, Ben Weisburd, Jiwoo Lee, Kevin Correia, Sophia Zeng, Jun Wan Shin

Brain Commun· May 2025

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Base editing strategies to convert CAG to CAA diminish the disease-causing mutation in Huntington's disease.
Doo Eun Choi, Jun Wan Shin, Sophia Zeng, Eun Pyo Hong, Jae-Hyun Jang

Elife· June 2024

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Genetic modifiers of somatic expansion and clinical phenotypes in Huntington's disease reveal shared and tissue-specific effects.

bioRxiv· June 2024

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Personalized allele-specific CRISPR-Cas9 strategies for myofibrillar myopathy 6.
Jun Wan Shin, Kyung-Hee Kim, Yukyeong Lee, Doo Eun Choi, Jong-Min Lee

medRxiv· February 2024

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Base editing strategies to convert CAG to CAA diminish the disease-causing mutation in Huntington's disease.
Doo Eun Choi, Jun Wan Shin, Sophia Zeng, Eun Pyo Hong, Jae-Hyun Jang

bioRxiv· April 2023

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Allele-specific silencing of the gain-of-function mutation in Huntington's disease using CRISPR/Cas9.
Jun Wan Shin, Eun Pyo Hong, Seri S Park, Doo Eun Choi, Ihn Sik Seong

JCI Insight· October 2022

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PAM-altering SNP-based allele-specific CRISPR-Cas9 therapeutic strategies for Huntington's disease.
Jun Wan Shin, Eun Pyo Hong, Seri S Park, Doo Eun Choi, Sophia Zeng

Mol Ther Methods Clin Dev· September 2022

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Haplotype-specific insertion-deletion variations for allele-specific targeting in Huntington's disease.
Jun Wan Shin, Aram Shin, Seri S Park, Jong-Min Lee

Mol Ther Methods Clin Dev· June 2022

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Genetic and Functional Analyses Point to FAN1 as the Source of Multiple Huntington Disease Modifier Effects.
Kyung-Hee Kim, Eun Pyo Hong, Jun Wan Shin, Michael J Chao, Jacob Loupe

Am J Hum Genet· July 2020

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Curcumin induces stabilization of Nrf2 protein through Keap1 cysteine modification.
Jun Wan Shin, Kyung-Soo Chun, Do-Hee Kim, Su-Jung Kim, Seong Hoon Kim

Biochem Pharmacol· March 2020

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Full sequence of mutant huntingtin 3'-untranslated region and modulation of its gene regulatory activity by endogenous microRNA.
Kyung-Hee Kim, Kawther Abu Elneel, Jun Wan Shin, Jae Whan Keum, David Seong

J Hum Genet· October 2019

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Population-specific genetic modification of Huntington's disease in Venezuela.
Michael J Chao, Kyung-Hee Kim, Jun Wan Shin, Diane Lucente, Vanessa C Wheeler

PLoS Genet· May 2018

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The prospects of CRISPR-based genome engineering in the treatment of neurodegenerative disorders.
Jun Wan Shin, Jong-Min Lee

Ther Adv Neurol Disord· November 2017

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Endogenous ω-3 Fatty Acid Production by fat-1 Transgene and Topically Applied Docosahexaenoic Acid Protect against UVB-induced Mouse Skin Carcinogenesis.
Hye-Won Yum, Jin Park, Hyun-Jung Park, Jun Wan Shin, Yong-Yeon Cho

Sci Rep· September 2017

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Novel allele-specific quantification methods reveal no effects of adult onset CAG repeats on HTT mRNA and protein levels.
Aram Shin, Baehyun Shin, Jun Wan Shin, Kyung-Hee Kim, Ranjit S Atwal

Hum Mol Genet· April 2017

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Permanent inactivation of Huntington's disease mutation by personalized allele-specific CRISPR/Cas9.
Jun Wan Shin, Kyung-Hee Kim, Michael J Chao, Ranjit S Atwal, Tammy Gillis

Hum Mol Genet· October 2016

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Protein tyrosine phosphatases PTP-1B, SHP-2, and PTEN facilitate Rb/E2F-associated apoptotic signaling.
Liza D Morales, Edgar A Casillas Pavón, Jun Wan Shin, Alexander Garcia, Mario Capetillo

PLoS One· June 2015

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Thymoquinone inhibits phorbol ester-induced activation of NF-κB and expression of COX-2, and induces expression of cytoprotective enzymes in mouse skin in vivo.
Joydeb Kumar Kundu, Lijia Liu, Jun-Wan Shin, Young-Joon Surh

Biochem Biophys Res Commun· September 2013

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Docosahexaenoic acid inhibits UVB-induced activation of NF-κB and expression of COX-2 and NOX-4 in HR-1 hairless mouse skin by blocking MSK1 signaling.
Mostafizur Rahman, Joydeb Kumar Kundu, Jun-Wan Shin, Hye-Kyung Na, Young-Joon Surh

PLoS One· April 2012

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Phloretin inhibits phorbol ester-induced tumor promotion and expression of cyclooxygenase-2 in mouse skin: extracellular signal-regulated kinase and nuclear factor-κB as potential targets.
Jun-Wan Shin, Joydeb Kumar Kundu, Young-Joon Surh

J Med Food· March 2012

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Zerumbone induces heme oxygenase-1 expression in mouse skin and cultured murine epidermal cells through activation of Nrf2.
Jun-Wan Shin, Kohta Ohnishi, Akira Murakami, Jeong-Sang Lee, Joydeb Kumar Kundu

Cancer Prev Res (Phila)· June 2011

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Ultraviolet B radiation activates NF-κB and induces iNOS expression in HR-1 hairless mouse skin: role of IκB kinase-β.
Eun-Jin Chang, Joydeb Kumar Kundu, Lijia Liu, Jun-Wan Shin, Young-Joon Surh

Mol Carcinog· April 2011

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cis-9,trans-11-conjugated linoleic acid down-regulates phorbol ester-induced NF-kappaB activation and subsequent COX-2 expression in hairless mouse skin by targeting IkappaB kinase and PI3K-Akt.
Dal-Mi Hwang, Joydeb Kumar Kundu, Jun-Wan Shin, Jung-Chul Lee, Hyong Joo Lee

Carcinogenesis· February 2007

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Antitumor promotional effects of a novel intestinal bacterial metabolite (IH-901) derived from the protopanaxadiol-type ginsenosides in mouse skin.
Ji-Yoon Lee, Jun-Wan Shin, Kyung-Soo Chun, Kwang-Kyun Park, Won-Yoon Chung

Carcinogenesis· February 2005

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Nitric oxide induces expression of cyclooxygenase-2 in mouse skin through activation of NF-kappaB.
Kyung-Soo Chun, Hyun-Ho Cha, Jun-Wan Shin, Hye-Kyung Na, Kwang-Kyun Park

Carcinogenesis· March 2004

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