Publications by authors named "Junko Ohkanda"

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Design and Evaluation of Bivalent K-Ras Inhibitors That Target the CAAX Binding Site and the Acidic Surface of Farnesyltransferase and Geranylgeranyltransferase I.
Naomi Horiuchi, Rania Omer, Fumitoshi Sugino, Nanami Ogino, Yoshihisa Inoue, Junko Ohkanda

Chemistry· May 2025

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Plasma membrane H-ATPase activation increases global transcript levels and promotes the shoot growth of light-grown Arabidopsis seedlings.
Satoru Naganawa Kinoshita, Kyomi Taki, Fumika Okamoto, Mika Nomoto, Koji Takahashi, Junko Ohkanda

Plant J· February 2025

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Fungal toxin fusicoccin enhances plant growth by upregulating 14-3-3 interaction with plasma membrane H-ATPase.
Hironaru Kiriyama, Satoru N Kinoshita, Yuki Hayashi, Rikako Honda, Shigemitsu Kasuga, Junko Ohkanda

Sci Rep· October 2024

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Functional evaluation of an electrophilic focused library to identify a covalent inhibitor against intrinsically disordered circadian clock transcription factors.
Kazuya Yamanaka, Yoshihisa Inoue, Miki Imanishi, Junko Ohkanda

Bioorg Med Chem Lett· January 2024

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Isoform-Selective Fluorescent Labeling of 14-3-3σ by Acrylamide-Containing Fusicoccins.
Kenta Tanaka, Yoshiya Hatano, Junko Ohkanda

Chemistry· July 2023

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Structure-activity-relationship study of semi-synthetically modified fusicoccins on their stabilization effect for 14-3-3-phospholigand interactions.
Nanami Ogino, Ryoma Masuda, Louvy Lynn Punzalan, Emi Yamashita, Shota Igaue, Junko Ohkanda

Bioorg Med Chem· November 2022

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Expression and purification of DYRK1A kinase domain in complex with its folding intermediate-selective inhibitor FINDY.
Ninako Kimura, Kanako Saito, Takashi Niwa, Masato Yamakawa, Shota Igaue, Junko Ohkanda

Protein Expr Purif· August 2022

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Design, synthesis, and functional evaluation of triazine-based bivalent agents that simultaneously target the active site and hot spot of phosphatase Cdc25B.
Yosei Nagaoka, Prakash Parvatkar, Go Hirai, Junko Ohkanda

Bioorg Med Chem Lett· September 2021

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Intrinsically Disordered Proteins as Regulators of Transient Biological Processes and as Untapped Drug Targets.
Yusuke Hosoya, Junko Ohkanda

Molecules· April 2021

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Identification of synthetic inhibitors for the DNA binding of intrinsically disordered circadian clock transcription factors.
Yusuke Hosoya, Wataru Nojo, Isao Kii, Takanori Suzuki, Miki Imanishi, Junko Ohkanda

Chem Commun (Camb)· September 2020

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Copper-Free Huisgen Cycloaddition for the 14-3-3-Templated Synthesis of Fusicoccin-Peptide Conjugates.
Ryoma Masuda, Yuuya Kawasaki, Kazunobu Igawa, Yoshiyuki Manabe, Hiroshi Fujii, Junko Ohkanda

Chem Asian J· March 2020

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A Guanidyl-Based Bivalent Peptidomimetic Inhibits K-Ras Prenylation and Association with c-Raf.
Mai Tsubamoto, Toan Khanh Le, Minghua Li, Taku Watanabe, Chiemi Matsumi, Junko Ohkanda

Chemistry· October 2019

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Dipicolylamine/Metal Complexes that Promote Direct Cell-Membrane Penetration of Octaarginine.
Yoshimasa Kawaguchi, Shoko Ise, Yusuke Azuma, Toshihide Takeuchi, Kenichi Kawano, Junko Ohkanda

Bioconjug Chem· February 2019

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Structural Effects of Fusicoccin upon Upregulation of 14-3-3-Phospholigand Interaction and Cytotoxic Activity.
Junko Ohkanda, Atsushi Kusumoto, Louvy Punzalan, Ryoma Masuda, Chenyu Wang

Chemistry· October 2018

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Intracellular Generation of a Diterpene-Peptide Conjugate that Inhibits 14-3-3-Mediated Interactions.
Prakash Parvatkar, Nobuo Kato, Motonari Uesugi, Shin-Ichi Sato, Junko Ohkanda

J Am Chem Soc· December 2015

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RNA-directed amino acid coupling as a model reaction for primitive coded translation.
Kazuo Harada, Shoko Aoyama, Akimasa Matsugami, Penmetcha K R Kumar, Masato Katahira, Junko Ohkanda

Chembiochem· April 2014

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Module assembly for designing multivalent mid-sized inhibitors of protein-protein interactions.
Junko Ohkanda

Chem Rec· December 2013

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Stabilization of physical RAF/14-3-3 interaction by cotylenin A as treatment strategy for RAS mutant cancers.
Manuela Molzan, Stefan Kasper, Lars Röglin, Malgorzata Skwarczynska, Takeshi Sassa, Junko Ohkanda

ACS Chem Biol· September 2013

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Peptidomimetic modification improves cell permeation of bivalent farnesyltransferase inhibitors.
Shinnosuke Machida, Mai Tsubamoto, Nobuo Kato, Kazuo Harada, Junko Ohkanda

Bioorg Med Chem· July 2013

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Antimicrobial N-(2-chlorobenzyl)-substituted hydroxamate is an inhibitor of 1-deoxy-D-xylulose 5-phosphate synthase.
Daisuke Hayashi, Nobuo Kato, Tomohisa Kuzuyama, Yasuo Sato, Junko Ohkanda

Chem Commun (Camb)· June 2013

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Chemical ligation of epoxide-containing fusicoccins and peptide fragments guided by 14-3-3 protein.
Toshio Maki, Akie Kawamura, Nobuo Kato, Junko Ohkanda

Mol Biosyst· May 2013

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A semisynthetic fusicoccane stabilizes a protein-protein interaction and enhances the expression of K+ channels at the cell surface.
Carolin Anders, Yusuke Higuchi, Kristin Koschinsky, Maria Bartel, Benjamin Schumacher, Junko Ohkanda

Chem Biol· April 2013

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A novel fusicoccin derivative preferentially targets hypoxic tumor cells and inhibits tumor growth in xenografts.
Koshi Kawakami, Miho Hattori, Takatsugu Inoue, Yuriko Maruyama, Junko Ohkanda

Anticancer Agents Med Chem· September 2012

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Protein recognition of hetero-/homoleptic ruthenium(II) tris(bipyridine)s for α-chymotrypsin and cytochrome c.
Yoshinobu Yamaguchi, Nobuo Kato, Hideki Azuma, Takeshi Nagasaki, Junko Ohkanda

Bioorg Med Chem Lett· March 2012

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Phosphopeptide-dependent labeling of 14-3-3 ζ proteins by fusicoccin-based fluorescent probes.
Michiko Takahashi, Akie Kawamura, Nobuo Kato, Tsuyoshi Nishi, Itaru Hamachi, Junko Ohkanda

Angew Chem Int Ed Engl· January 2012

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