Publications by authors named "Justin Ichida"

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AAV delivery of full-length SYNGAP1 rescues epileptic and behavioral phenotypes in a mouse model of SYNGAP1-related disorders.
Meagan A Quinlan, Rong Guo, Andrew G Clark, Emily M Luber, Robert J Christian, Justin K Ichida

Mol Ther· December 2025

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Elevated tripeptidyl-peptidase 1 corrects multiple disease phenotypes in a mouse model of juvenile neuronal ceroid lipofuscinosis.
Whitney Banach-Petrosky, Katherine E Larrimore, Elizabeth H Sleat, Allyson Bazer, Benjamin Samuels, Justin K Ichida

Mol Ther Methods Clin Dev· December 2025

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The Ku80-p53-SIRT1 axis in DNA damage response contributes to sporadic and familial ALS and FTD.
Yong-Woo Jun, Soojin Lee, Sandra Almeida, Kristine K Freude, Justin K Ichida

Nat Commun· December 2025

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Spatially patterned kidney assembloids recapitulate progenitor self-assembly and enable high-fidelity in vivo disease modeling.
Biao Huang, Pedro Medina, Jincan He, Zipeng Zeng, Sunghyun Kim, Justin Ichida

Cell Stem Cell· October 2025

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AAV-mediated exon skipping therapy for Usher syndrome, type 2A.
Stephanie A Mauriac, Jiyoon Lee, Jingyuan Zhang, Jiahe Jin, Carl Nist-Lund, Justin Ichida

Mol Ther· September 2025

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Antisense oligonucleotide depletion of is a broad-spectrum therapeutic strategy for ALS.
Sai Zhang, Tobias Moll, Jasper Rubin-Sigler, Sharon Tu, Shuya Li, Justin K Ichida

medRxiv· August 2025

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Single-cell polygenic risk scores dissect cellular and molecular heterogeneity of complex human diseases.
Sai Zhang, Hantao Shu, Jingtian Zhou, Jasper Rubin-Sigler, Xiaoyu Yang, Justin K Ichida

Nat Biotechnol· July 2025

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KCTD20 suppression mitigates excitotoxicity in tauopathy patient organoids.
Joshua E Berlind, Jesse D Lai, Cecilia Lie, Jokabeth Vicente, Kelsey Lam, Justin K Ichida

Neuron· April 2025

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Elucidating the Synergistic Effect of the PrimeC Combination for Amyotrophic Lateral Sclerosis in Human Induced Pluripotent Stem Cell-Derived Motor Neurons and Mouse Models.
Shiran Salomon-Zimri, Nitai Kerem, Gabriel R Linares, Niva Russek-Blum, Justin K Ichida

Pharmaceuticals (Basel)· April 2025

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An ALS assembly modulator signature in peripheral blood mononuclear cells: implications for ALS pathophysiology, therapeutics, and diagnostics.
Shao Feng Yu, Maya Michon, Anuradha F Lingappa, Kumar Paulvannan, Dennis Solas, Justin Ichida

Clin Proteomics· April 2025

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Human iPSC-Derived Motor Neuron Innervation Enhances the Differentiation of Muscle Bundles Engineered with Benchtop Fabrication Techniques.
Jeffrey W Santoso, Stephanie K Do, Riya Verma, Alexander V Do, Eric Hendricks, Justin K Ichida

ACS Biomater Sci Eng· March 2025

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Human iPSC-derived motor neuron innervation enhances the differentiation of muscle bundles engineered with benchtop fabrication techniques.
Jeffrey W Santoso, Stephanie K Do, Riya Verma, Alexander V Do, Eric Hendricks, Justin K Ichida

bioRxiv· December 2024

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Deconvolution of polygenic risk score in single cells unravels cellular and molecular heterogeneity of complex human diseases.
Sai Zhang, Hantao Shu, Jingtian Zhou, Jasper Rubin-Sigler, Xiaoyu Yang, Justin K Ichida

bioRxiv· May 2024

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KCNJ2 inhibition mitigates mechanical injury in a human brain organoid model of traumatic brain injury.
Jesse D Lai, Joshua E Berlind, Gabriella Fricklas, Cecilia Lie, Jean-Paul Urenda, Justin K Ichida

Cell Stem Cell· April 2024

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Author Correction: Central role for PICALM in amyloid-β blood-brain barrier transcytosis and clearance.
Zhen Zhao, Abhay P Sagare, Qingyi Ma, Matthew R Halliday, Pan Kong, Justin K Ichida

Nat Neurosci· January 2024

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Protein Assembly Modulation: A New Approach to Amyotrophic Lateral Sclerosis (ALS) Therapeutics.
Shao Feng Yu, Kumar Paulvannan, Dennis Solas, Anuradha F Lingappa, Ana Raquel Moreira, Justin Ichida

J Exp Neurol· January 2024

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CLIP-Seq analysis enables the design of protective ribosomal RNA bait oligonucleotides against ALS/FTD poly-GR pathophysiology.
Juan A Ortega, Ivan R Sasselli, Marco Boccitto, Andrew C Fleming, Tyler R Fortuna, Justin K Ichida

Sci Adv· November 2023

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Analysis of proteome-wide degradation dynamics in ALS SOD1 iPSC-derived patient neurons reveals disrupted VCP homeostasis.
Konstantinos Tsioras, Kevin C Smith, Seby L Edassery, Mehraveh Garjani, Yichen Li, Justin K Ichida

Cell Rep· October 2023

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The C9ORF72 repeat expansion alters neurodevelopment.
Eric Hendricks, Alicia M Quihuis, Shu-Ting Hung, Jonathan Chang, Nomongo Dorjsuren, Justin K Ichida

Cell Rep· August 2023

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Moderate intrinsic phenotypic alterations in ALS/FTD iPSC-microglia despite the presence of C9orf72 pathological features.
Ileana Lorenzini, Eric Alsop, Jennifer Levy, Lauren M Gittings, Deepti Lall, Justin Ichida

Front Cell Neurosci· June 2023

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Downregulation of Hsp90 and the antimicrobial peptide Mtk suppresses poly(GR)-induced neurotoxicity in C9ORF72-ALS/FTD.
Soojin Lee, Yong-Woo Jun, Gabriel R Linares, Brandon Butler, Yeliz Yuva-Adyemir, Justin K Ichida

Neuron· May 2023

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Transcriptomic analysis of feeder-free culture system for maintaining naïve-state pluripotency in human pluripotent stem cells.
Wataru Isono, Tomoyuki Kawasaki, Justin K Ichida, Kazunori Nagasaka, Osamu Hiraike

Stem Cell Investig· April 2023

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Molecular Tweezers: Supramolecular Hosts with Broad-Spectrum Biological Applications.
Hedieh Shahpasand-Kroner, Ibrar Siddique, Ravinder Malik, Gabriel R Linares, Magdalena I Ivanova, Justin Ichida

Pharmacol Rev· March 2023

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SYF2 suppression mitigates neurodegeneration in models of diverse forms of ALS.
Gabriel R Linares, Yichen Li, Wen-Hsuan Chang, Jasper Rubin-Sigler, Stacee Mendonca, Justin K Ichida

Cell Stem Cell· February 2023

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PIKFYVE inhibition mitigates disease in models of diverse forms of ALS.
Shu-Ting Hung, Gabriel R Linares, Wen-Hsuan Chang, Yunsun Eoh, Gopinath Krishnan, Justin K Ichida

Cell· February 2023

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