Publications by authors named "Justin Sysol"

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Caveolin-1 Is a Central Mediator of Acute Lung Injury in an Animal Model of Sickle Cell Disease.
Clare C Prohaska, Justin R Sysol, Nicole Jones, Robert W Wysocki, Suellen D Oliveira

Pulm Circ· October 2025

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The mitochondrial unfolded protein response and metabolic reprogramming promote PASMC proliferation in response to sphingosine kinase-1/sphingosine-1-phosphate signaling.
Angelia D Lockett, Aaron Snow, Pontian Adogamhe, Justin Sysol, Manas Yadav

bioRxiv· June 2025

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Lipodystrophy in methylmalonic acidemia associated with elevated FGF21 and abnormal methylmalonylation.
Irini Manoli, Justin R Sysol, PamelaSara E Head, Madeline W Epping, Oksana Gavrilova

JCI Insight· February 2024

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Training Medical Student Counselors for the Rochester Model, a Hospital Tobacco Treatment Program.
John C Grable, Kevin Shan, Matthew Wang, Daniel D Han, Kristen Sportiello, Justin R Sysol

J Multidiscip Healthc· February 2024

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Sphingosine Kinase 1 Deficiency in Smooth Muscle Cells Protects against Hypoxia-Mediated Pulmonary Hypertension via YAP1 Signaling.
Jiwang Chen, Angelia Lockett, Shuangping Zhao, Long Shuang Huang, Yifan Wang, Justin R Sysol

Int J Mol Sci· November 2022

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Cortactin loss protects against hemin-induced acute lung injury in sickle cell disease.
Nicole M Jones, Justin R Sysol, Sunit Singla, Patricia Smith, George E Sandusky

Am J Physiol Lung Cell Mol Physiol· June 2022

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FGF21 underlies a hormetic response to metabolic stress in methylmalonic acidemia.
Irini Manoli, Justin R Sysol, Madeline W Epping, Lina Li, Cindy Wang

JCI Insight· December 2018

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Progressive glomerular and tubular damage in sickle cell trait and sickle cell anemia mouse models.
Santosh L Saraf, Justin R Sysol, Alexandru Susma, Suman Setty, Xu Zhang

Transl Res· July 2018

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Micro-RNA-1 is decreased by hypoxia and contributes to the development of pulmonary vascular remodeling via regulation of sphingosine kinase 1.
Justin R Sysol, Jiwang Chen, Sunit Singla, Shuangping Zhao, Suzy Comhair

Am J Physiol Lung Cell Mol Physiol· March 2018

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Hemin Causes Lung Microvascular Endothelial Barrier Dysfunction by Necroptotic Cell Death.
Sunit Singla, Justin R Sysol, Benjamin Dille, Nicole Jones, Jiwang Chen

Am J Respir Cell Mol Biol· September 2017

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Genome-Wide Analysis Identifies IL-18 and FUCA2 as Novel Genes Associated with Diastolic Function in African Americans with Sickle Cell Disease.
Julio D Duarte, Ankit A Desai, Justin R Sysol, Taimur Abbasi, Amit R Patel

PLoS One· August 2017

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Loss of lung WWOX expression causes neutrophilic inflammation.
Sunit Singla, Jiwang Chen, Shruthi Sethuraman, Justin R Sysol, Amulya Gampa

Am J Physiol Lung Cell Mol Physiol· June 2017

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Nicotinamide Phosphoribosyltransferase Promotes Pulmonary Vascular Remodeling and Is a Therapeutic Target in Pulmonary Arterial Hypertension.
Jiwang Chen, Justin R Sysol, Sunit Singla, Shuangping Zhao, Aya Yamamura

Circulation· April 2017

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Defects in muscle branched-chain amino acid oxidation contribute to impaired lipid metabolism.
Carles Lerin, Allison B Goldfine, Tanner Boes, Manway Liu, Simon Kasif, Justin R Sysol

Mol Metab· October 2016

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PDGF induces SphK1 expression via Egr-1 to promote pulmonary artery smooth muscle cell proliferation.
Justin R Sysol, Viswanathan Natarajan, Roberto F Machado

Am J Physiol Cell Physiol· June 2016

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Deficiency of Akt1, but not Akt2, attenuates the development of pulmonary hypertension.
Haiyang Tang, Jiwang Chen, Dustin R Fraidenburg, Shanshan Song, Justin R Sysol

Am J Physiol Lung Cell Mol Physiol· January 2015

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The sphingosine kinase 1/sphingosine-1-phosphate pathway in pulmonary arterial hypertension.
Jiwang Chen, Haiyang Tang, Justin R Sysol, Liliana Moreno-Vinasco, Krystyna M Shioura

Am J Respir Crit Care Med· November 2014

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Targeting proximal tubule mitochondrial dysfunction attenuates the renal disease of methylmalonic acidemia.
Irini Manoli, Justin R Sysol, Lingli Li, Pascal Houillier, Caterina Garone

Proc Natl Acad Sci U S A· August 2013

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Evaluation of a reliable and cost-effective method of DNA isolation for mouse genotyping.
Justin R Sysol, Carrie Kempf, Michelle N Helton, Yangbasai Dong, Daocheng Zhu

Biotechnol Lett· April 2013

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Exome sequencing identifies ACSF3 as a cause of combined malonic and methylmalonic aciduria.
Jennifer L Sloan, Jennifer J Johnston, Irini Manoli, Randy J Chandler, Caitlin Krause, Justin R Sysol

Nat Genet· August 2011

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