Publications by authors named "K Biggadike"

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Discovery of 6-Amino-2-{[(1S)-1-methylbutyl]oxy}-9-[5-(1-piperidinyl)pentyl]-7,9-dihydro-8H-purin-8-one (GSK2245035), a Highly Potent and Selective Intranasal Toll-Like Receptor 7 Agonist for the Treatment of Asthma.
Keith Biggadike, Mahbub Ahmed, Doug I Ball, Diane M Coe, Deidre A Dalmas Wilk

J Med Chem· March 2016

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Early clinical evaluation of the intranasal TLR7 agonist GSK2245035: Use of translational biomarkers to guide dosing and confirm target engagement.
D Tsitoura, C Ambery, M Price, W Powley, S Garthside, K Biggadike

Clin Pharmacol Ther· October 2015

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Discovery of a rapidly metabolized, long-acting β(2) adrenergic receptor agonist with a short onset time incorporating a sulfone group suitable for once-daily dosing.
Panayiotis A Procopiou, Victoria J Barrett, Keith Biggadike, Peter R Butchers, Andrew Craven

J Med Chem· January 2014

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Discovery of GW870086: a potent anti-inflammatory steroid with a unique pharmacological profile.
I J Uings, D Needham, J Matthews, M Haase, R Austin, K Biggadike

Br J Pharmacol· July 2013

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Effect of the TRPV1 antagonist SB-705498 on the nasal parasympathetic reflex response in the ovalbumin sensitized guinea pig.
Kumar Changani, Sarah Hotee, Simon Campbell, Kashmira Pindoria, Laura Dinnewell, Keith Biggadike

Br J Pharmacol· June 2013

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