Publications by authors named "Kaelin D Fleming"

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Structural insights into perilipin 3 membrane association in response to diacylglycerol accumulation.
Yong Mi Choi, Dalila Ajjaji, Kaelin D Fleming, Peter P Borbat, Meredith L Jenkins, Brandon E Moeller, Shaveen Fernando, Surita R Bhatia, Jack H Freed, John E Burke

Nat Commun· June 2023

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Molecular basis for differential activation of p101 and p84 complexes of PI3Kγ by Ras and GPCRs.
Manoj K Rathinaswamy, Meredith L Jenkins, Benjamin R Duewell, Xuxiao Zhang, Noah J Harris, Kaelin D Fleming

Cell Rep· March 2023

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Biochemical Characterization of the TINTIN Module of the NuA4 Complex Reveals Allosteric Regulation of Nucleosome Interaction.
Udit Dalwadi, Elaina Corrado, Kaelin D Fleming, Brandon E Moeller, Sung-Eun Nam

Mol Cell Biol· November 2022

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Activation of the essential kinase PDK1 by phosphoinositide-driven trans-autophosphorylation.
Aleksandra Levina, Kaelin D Fleming, John E Burke, Thomas A Leonard

Nat Commun· April 2022

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HDX-MS-optimized approach to characterize nanobodies as tools for biochemical and structural studies of class IB phosphoinositide 3-kinases.
Manoj K Rathinaswamy, Kaelin D Fleming, Udit Dalwadi, Els Pardon, Noah J Harris

Structure· December 2021

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Biochemical Insight into Novel Rab-GEF Activity of the Mammalian TRAPPIII Complex.
Noah J Harris, Meredith L Jenkins, Udit Dalwadi, Kaelin D Fleming, Sung-Eun Nam

J Mol Biol· September 2021

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In vitro reconstitution of Sgk3 activation by phosphatidylinositol 3-phosphate.
Daniel Pokorny, Linda Truebestein, Kaelin D Fleming, John E Burke, Thomas A Leonard

J Biol Chem· August 2021

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The middle lipin domain adopts a membrane-binding dimeric protein fold.
Weijing Gu, Shujuan Gao, Huan Wang, Kaelin D Fleming, Reece M Hoffmann

Nat Commun· August 2021

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Structure of autoinhibited Akt1 reveals mechanism of PIP-mediated activation.
Linda Truebestein, Harald Hornegger, Dorothea Anrather, Markus Hartl, Kaelin D Fleming

Proc Natl Acad Sci U S A· August 2021

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Structure of the phosphoinositide 3-kinase (PI3K) p110γ-p101 complex reveals molecular mechanism of GPCR activation.
Manoj K Rathinaswamy, Udit Dalwadi, Kaelin D Fleming, Carson Adams, Jordan T B Stariha

Sci Adv· August 2021

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Disease-related mutations in PI3Kγ disrupt regulatory C-terminal dynamics and reveal a path to selective inhibitors.
Manoj K Rathinaswamy, Zied Gaieb, Kaelin D Fleming, Chiara Borsari, Noah J Harris

Elife· March 2021

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The substrate specificity of the human TRAPPII complex's Rab-guanine nucleotide exchange factor activity.
Meredith L Jenkins, Noah J Harris, Udit Dalwadi, Kaelin D Fleming, Daniel S Ziemianowicz

Commun Biol· December 2020

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