Nat Commun June 2023 PMID 37268630

Structural insights into perilipin 3 membrane association in response to diacylglycerol accumulation.

Yong Mi Choi, Dalila Ajjaji, Kaelin D Fleming, Peter P Borbat, Meredith L Jenkins, Brandon E Moeller, Shaveen Fernando, Surita R Bhatia, Jack H Freed, John E Burke, Abdou Rachid Thiam, Michael V Airola

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Mentions

22
Peak: 19 in Jun 2023
across 2 sources since Mar 2023

Extended reach

43,178
potential audience

Total likes

82

Video views

50

Mentions per month

Mar 2023 – Sep 2023

Where it's discussed

  • X / Twitter21 posts
  • YouTube1 videos

AI synopsis

What people are saying

The group shows enthusiasm for the study, highlighting its relevance through phrases like 'structural insights' and 'collaborative study.' The mention of conference posters and preprints illustrates active engagement and interest, while references to lipid-protein interactions emphasize the perceived significance of the findings in the field.

AgreementModerate agreement

Most discussions express approval and recognition of the significance of the research, supporting its contributions.

InterestHigh interest

Numerous mentions of conference presentations, posters, and preprints indicate high interest in the topic and findings.

EngagementHigh engagement

Posts include references to specific details like the protein PLIN3, membrane interactions, and experimental methods, showing active engagement.

ImpactModerate impact

There is a recognition that the study advances understanding of lipid membrane dynamics, which could influence future research directions.

Abstract in brief

  • The study explores how lipid composition, specifically molecules like phosphatidic acid and diacylglycerol (DAG), influences the recruitment of perilipin 3 (PLIN3) to membranes and lipid droplets during their formation.
  • When PLIN3 binds to DAG-enriched membranes, it causes structural changes in its PAT domain, shifting from a disordered to a more ordered, folded but dynamic structure.
  • In cells, PLIN3 is directed to DAG-rich endoplasmic reticulum membranes through interactions involving the PAT domain and 11mer repeats, highlighting how certain lipids and protein domains work together to facilitate lipid droplet formation.]

Top posts

Most liked on X and Bluesky
Michael Airola
@airola_lab · X

Our collaborative study with @Rachid_Thiam, John Burke, & Peter Borbat now out in @NatureComms. Congrats to @yongmi88514, Dalila Ajjaji, and all authors Structural insights into perilipin 3 membrane association in response to diacylglycerol accumulation https://t.co/NtbbW6yLXm

Jun 5, 2023 · 74 likes · 20 shares · 561 followers View post →
Michael Airola
@airola_lab · X

if you're at the #deuel conference make sure to check out Yong Mi's poster on perilipin 3 membrane association! if you're not, check out the preprint: Structural insights into perilipin 3 membrane association in response to diacylglycerol accumulation https://t.co/IjsUFaHpdF https://t.co/bodf5bnFn8

Mar 10, 2023 · 8 likes · 2 shares · 561 followers View post →
Rutter Lab
@RutterLab · X

RT @airola_lab: Our collaborative study with @Rachid_Thiam, John Burke, & Peter Borbat now out in @NatureComms. Congrats to @yongmi88514, D…

Jun 5, 2023 · 20 shares · 8,737 followers View post →
Jeremy Baskin
@basktastic · X

RT @airola_lab: Our collaborative study with @Rachid_Thiam, John Burke, & Peter Borbat now out in @NatureComms. Congrats to @yongmi88514, D…

Jun 5, 2023 · 20 shares · 5,053 followers View post →
ESPCI Alumni
@ESPCI_Alumni · X

RT @airola_lab: Our collaborative study with @Rachid_Thiam, John Burke, & Peter Borbat now out in @NatureComms. Congrats to @yongmi88514, D…

Jun 5, 2023 · 20 shares · 4,606 followers View post →
Judith Simcox PhD
@JudithSimcox · X

RT @airola_lab: Our collaborative study with @Rachid_Thiam, John Burke, & Peter Borbat now out in @NatureComms. Congrats to @yongmi88514, D…

Jun 5, 2023 · 20 shares · 3,038 followers View post →

All mentions

Phenomics
@Phenomics_J · X

RT @airola_lab: Our collaborative study with @Rachid_Thiam, John Burke, & Peter Borbat now out in @NatureComms. Congrats to @yongmi88514, D…

Jun 29, 2023 · 20 shares · 1,528 followers View post →
Stevanus A. Listian
@ListianSA · X

RT @airola_lab: Our collaborative study with @Rachid_Thiam, John Burke, & Peter Borbat now out in @NatureComms. Congrats to @yongmi88514, D…

Jun 6, 2023 · 20 shares · 212 followers View post →
Sivaprakasam Chinnarasu, PhD
@sivabdubio · X

RT @airola_lab: Our collaborative study with @Rachid_Thiam, John Burke, & Peter Borbat now out in @NatureComms. Congrats to @yongmi88514, D…

Jun 6, 2023 · 20 shares · 101 followers View post →
Sphingolipid Biology
@SL_Biology · X

RT @airola_lab: Our collaborative study with @Rachid_Thiam, John Burke, & Peter Borbat now out in @NatureComms. Congrats to @yongmi88514, D…

Jun 6, 2023 · 20 shares · 1,138 followers View post →
BüttnerLab
@ButtnerLab · X

RT @airola_lab: Our collaborative study with @Rachid_Thiam, John Burke, & Peter Borbat now out in @NatureComms. Congrats to @yongmi88514, D…

Jun 6, 2023 · 20 shares · 914 followers View post →
Albert Pol Lab
@AlbertPol10 · X

RT @airola_lab: Our collaborative study with @Rachid_Thiam, John Burke, & Peter Borbat now out in @NatureComms. Congrats to @yongmi88514, D…

Jun 6, 2023 · 20 shares · 901 followers View post →
Manojit Swamynathan
@manojit_ms · X

RT @airola_lab: Our collaborative study with @Rachid_Thiam, John Burke, & Peter Borbat now out in @NatureComms. Congrats to @yongmi88514, D…

Jun 5, 2023 · 20 shares · 478 followers View post →
Claudia Matthaeus
@cmatthaeus2 · X

RT @airola_lab: Our collaborative study with @Rachid_Thiam, John Burke, & Peter Borbat now out in @NatureComms. Congrats to @yongmi88514, D…

Jun 5, 2023 · 20 shares · 791 followers View post →
Maria Fedorova
@FedorovaLab · X

RT @airola_lab: Our collaborative study with @Rachid_Thiam, John Burke, & Peter Borbat now out in @NatureComms. Congrats to @yongmi88514, D…

Jun 5, 2023 · 20 shares · 2,607 followers View post →
Ilya Levental
@LeventalLab · X

RT @airola_lab: Our collaborative study with @Rachid_Thiam, John Burke, & Peter Borbat now out in @NatureComms. Congrats to @yongmi88514, D…

Jun 5, 2023 · 20 shares · 2,826 followers View post →
Jeremy Baskin
@basktastic · X

RT @airola_lab: Our collaborative study with @Rachid_Thiam, John Burke, & Peter Borbat now out in @NatureComms. Congrats to @yongmi88514, D…

Jun 5, 2023 · 20 shares · 5,053 followers View post →
ESPCI Alumni
@ESPCI_Alumni · X

RT @airola_lab: Our collaborative study with @Rachid_Thiam, John Burke, & Peter Borbat now out in @NatureComms. Congrats to @yongmi88514, D…

Jun 5, 2023 · 20 shares · 4,606 followers View post →
Abdou Rachid Thiam
@Rachid_Thiam · X

RT @airola_lab: Our collaborative study with @Rachid_Thiam, John Burke, & Peter Borbat now out in @NatureComms. Congrats to @yongmi88514, D…

Jun 5, 2023 · 20 shares · 1,117 followers View post →
Jeeyun Chung
@JeeyunC · X

RT @airola_lab: Our collaborative study with @Rachid_Thiam, John Burke, & Peter Borbat now out in @NatureComms. Congrats to @yongmi88514, D…

Jun 5, 2023 · 20 shares · 1,065 followers View post →
Rutter Lab
@RutterLab · X

RT @airola_lab: Our collaborative study with @Rachid_Thiam, John Burke, & Peter Borbat now out in @NatureComms. Congrats to @yongmi88514, D…

Jun 5, 2023 · 20 shares · 8,737 followers View post →
Judith Simcox PhD
@JudithSimcox · X

RT @airola_lab: Our collaborative study with @Rachid_Thiam, John Burke, & Peter Borbat now out in @NatureComms. Congrats to @yongmi88514, D…

Jun 5, 2023 · 20 shares · 3,038 followers View post →
Bahmanyar lab
@Bahmanyarlab · X

RT @airola_lab: Our collaborative study with @Rachid_Thiam, John Burke, & Peter Borbat now out in @NatureComms. Congrats to @yongmi88514, D…

Jun 5, 2023 · 20 shares · 1,159 followers View post →
Michael Airola
@airola_lab · X

Our collaborative study with @Rachid_Thiam, John Burke, & Peter Borbat now out in @NatureComms. Congrats to @yongmi88514, Dalila Ajjaji, and all authors Structural insights into perilipin 3 membrane association in response to diacylglycerol accumulation https://t.co/NtbbW6yLXm

Jun 5, 2023 · 74 likes · 20 shares · 561 followers View post →
Kermit Murray
@kermitmurray · X

(Nature MS) Structural insights into perilipin 3 membrane association in response to diacylglycerol accumulation (RSS) #nature #MassSpec https://t.co/J3pgqBmbHV https://t.co/Zp8T1yOpYW

Jun 2, 2023 · 1,970 followers View post →
Judith Simcox PhD
@JudithSimcox · X

RT @airola_lab: if you're at the #deuel conference make sure to check out Yong Mi's poster on perilipin 3 membrane association! if you're…

Mar 10, 2023 · 2 shares · 3,038 followers View post →
Michael Airola
@airola_lab · X

if you're at the #deuel conference make sure to check out Yong Mi's poster on perilipin 3 membrane association! if you're not, check out the preprint: Structural insights into perilipin 3 membrane association in response to diacylglycerol accumulation https://t.co/IjsUFaHpdF https://t.co/bodf5bnFn8

Mar 10, 2023 · 8 likes · 2 shares · 561 followers View post →