Structural insights into perilipin 3 membrane association in response to diacylglycerol accumulation.

Yong Mi Choi, Dalila Ajjaji, Kaelin D Fleming, Peter P Borbat, Meredith L Jenkins, Brandon E Moeller, Shaveen Fernando, Surita R Bhatia, Jack H Freed, John E Burke, Abdou Rachid Thiam, Michael V Airola

June 2023 Nat Commun

Synopsis of Social media discussions

The group shows enthusiasm for the study, highlighting its relevance through phrases like 'structural insights' and 'collaborative study.' The mention of conference posters and preprints illustrates active engagement and interest, while references to lipid-protein interactions emphasize the perceived significance of the findings in the field.

A
Agreement
 Moderate agreement

Most discussions express approval and recognition of the significance of the research, supporting its contributions.

I
Interest
 High level of interest

Numerous mentions of conference presentations, posters, and preprints indicate high interest in the topic and findings.

E
Engagement
 High engagement

Posts include references to specific details like the protein PLIN3, membrane interactions, and experimental methods, showing active engagement.

I
Impact
 Moderate level of impact

There is a recognition that the study advances understanding of lipid membrane dynamics, which could influence future research directions.

Social Mentions

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1 Videos

Twitter

21 Posts

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50

Total Likes

82

Extended Reach

43,178

Social Features

22

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Structural Analysis of Perilipin 3 Membrane Association in Lipid Droplet Formation

Structural Analysis of Perilipin 3 Membrane Association in Lipid Droplet Formation

This video explores how lipid composition influences perilipin 3 recruitment to membranes and lipid droplets, highlighting structural changes in the PAT domain during DAG-enriched membrane binding and its role in lipid droplet biogenesis.

STEM RTCL TV

September 24, 2023

50 views

  • Phenomics
    @Phenomics_J (Twitter)

    RT @airola_lab: Our collaborative study with @Rachid_Thiam, John Burke, & Peter Borbat now out in @NatureComms. Congrats to @yongmi88514, D…
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    June 29, 2023

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  • Stevanus A. Listian
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    RT @airola_lab: Our collaborative study with @Rachid_Thiam, John Burke, & Peter Borbat now out in @NatureComms. Congrats to @yongmi88514, D…
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    RT @airola_lab: Our collaborative study with @Rachid_Thiam, John Burke, & Peter Borbat now out in @NatureComms. Congrats to @yongmi88514, D…
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    RT @airola_lab: Our collaborative study with @Rachid_Thiam, John Burke, & Peter Borbat now out in @NatureComms. Congrats to @yongmi88514, D…
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  • Abdou Rachid Thiam
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  • Judith Simcox PhD
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  • Michael Airola
    @airola_lab (Twitter)

    Our collaborative study with @Rachid_Thiam, John Burke, & Peter Borbat now out in @NatureComms. Congrats to @yongmi88514, Dalila Ajjaji, and all authors Structural insights into perilipin 3 membrane association in response to diacylglycerol accumulation https://t.co/NtbbW6yLXm
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    June 5, 2023

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  • Kermit Murray
    @kermitmurray (Twitter)

    (Nature MS) Structural insights into perilipin 3 membrane association in response to diacylglycerol accumulation (RSS) #nature #MassSpec https://t.co/J3pgqBmbHV https://t.co/Zp8T1yOpYW
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    June 2, 2023

  • Judith Simcox PhD
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    RT @airola_lab: if you're at the #deuel conference make sure to check out Yong Mi's poster on perilipin 3 membrane association! if you're…
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    March 10, 2023

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  • Michael Airola
    @airola_lab (Twitter)

    if you're at the #deuel conference make sure to check out Yong Mi's poster on perilipin 3 membrane association! if you're not, check out the preprint: Structural insights into perilipin 3 membrane association in response to diacylglycerol accumulation https://t.co/IjsUFaHpdF https://t.co/bodf5bnFn8
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    March 10, 2023

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Abstract Synopsis

  • The study explores how lipid composition, specifically molecules like phosphatidic acid and diacylglycerol (DAG), influences the recruitment of perilipin 3 (PLIN3) to membranes and lipid droplets during their formation.
  • When PLIN3 binds to DAG-enriched membranes, it causes structural changes in its PAT domain, shifting from a disordered to a more ordered, folded but dynamic structure.
  • In cells, PLIN3 is directed to DAG-rich endoplasmic reticulum membranes through interactions involving the PAT domain and 11mer repeats, highlighting how certain lipids and protein domains work together to facilitate lipid droplet formation.]