Publications by authors named "Kaeling Tan"

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Systematic over-expression of secondary metabolism transcription factors to reveal the pharmaceutical potential of Aspergillus nidulans.
Shuhui Guo, Lakhansing Pardeshi, Longguang Qin, Chris Y Cheung, Xiaofeng Liu, Kaeling Tan

Commun Biol· October 2025

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Microtubule dynamics is a therapeutic vulnerability in VHL-deficient renal cell carcinoma.
Yue Pu, Ziruoyu Wang, Shishi Tao, Eun Ju Yang, Songlin Wu, Kaeling Tan

Int J Biol Sci· May 2025

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Temporal transcriptional response of during macrophage infection reveals a multifaceted transcriptional regulator CgXbp1 important for macrophage response and fluconazole resistance.
Maruti Nandan Rai, Qing Lan, Chirag Parsania, Rikky Rai, Niranjan Shirgaonkar, Kaeling Tan

Elife· October 2024

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An effective strategy for identifying autogenous regulation of transcription factors in filamentous fungi.
Longguang Qin, Shuhui Guo, Ang Li, Lu Fan, Kaeling Tan

Microbiol Spectr· December 2023

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The KdmB-EcoA-RpdA-SntB chromatin complex binds regulatory genes and coordinates fungal development with mycotoxin synthesis.
Betim Karahoda, Lakhansing Pardeshi, Mevlut Ulas, Zhiqiang Dong, Niranjan Shirgaonkar, Kaeling Tan

Nucleic Acids Res· September 2022

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Chromatin profiling reveals heterogeneity in clinical isolates of the human pathogen Aspergillus fumigatus.
Ana Cristina Colabardini, Fang Wang, Zhengqiang Miao, Lakhansing Pardeshi, Clara Valero, Kaeling Tan

PLoS Genet· January 2022

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Co-option of an extracellular protease for transcriptional control of nutrient degradation in the fungus Aspergillus nidulans.
Ang Li, Chirag Parsania, Kaeling Tan, Richard B Todd, Koon Ho Wong

Commun Biol· December 2021

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Transcription in fungal conidia before dormancy produces phenotypically variable conidia that maximize survival in different environments.
Fang Wang, Pooja Sethiya, Xiaohui Hu, Shuhui Guo, Yingying Chen, Kaeling Tan

Nat Microbiol· August 2021

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Carbon Catabolite Repression Governs Diverse Physiological Processes and Development in Aspergillus nidulans.
Yingying Chen, Liguo Dong, Md Ashiqul Alam, Lakhansing Pardeshi, Zhengqiang Miao, Kaeling Tan

mBio· February 2021

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Carbon Catabolite Repression in Filamentous Fungi Is Regulated by Phosphorylation of the Transcription Factor CreA.
Leandro José de Assis, Lilian Pereira Silva, Ozgur Bayram, Paul Dowling, Olaf Kniemeyer, Kaeling Tan

mBio· January 2021

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Synthetic lethality of RB1 and aurora A is driven by stathmin-mediated disruption of microtubule dynamics.
Junfang Lyu, Eun Ju Yang, Baoyuan Zhang, Changjie Wu, Lakhansing Pardeshi, Kaeling Tan

Nat Commun· October 2020

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Characterization of BRCA1-deficient premalignant tissues and cancers identifies Plekha5 as a tumor metastasis suppressor.
Jianlin Liu, Ragini Adhav, Kai Miao, Sek Man Su, Lihua Mo, Kaeling Tan

Nat Commun· September 2020

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A Three-Way Combinatorial CRISPR Screen for Analyzing Interactions among Druggable Targets.
Peng Zhou, Becky K C Chan, Yuk Kei Wan, Chaya T L Yuen, Gigi C G Choi, Kaeling Tan

Cell Rep· August 2020

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The Aspergillus fumigatus transcription factor RglT is important for gliotoxin biosynthesis and self-protection, and virulence.
Laure N A Ries, Lakhansing Pardeshi, Zhiqiang Dong, Kaeling Tan, Jacob L Steenwyk

PLoS Pathog· July 2020

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NOTCH1 activation compensates BRCA1 deficiency and promotes triple-negative breast cancer formation.
Kai Miao, Josh Haipeng Lei, Monica Vishnu Valecha, Aiping Zhang, Jun Xu, Kaeling Tan

Nat Commun· June 2020

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Transcriptomic analysis reveals global and temporal transcription changes during Candida glabrata adaptation to an oxidative environment.
Pooja Sethiya, Maruti Nandan Rai, Rikky Rai, Chirag Parsania, Kaeling Tan

Fungal Biol· May 2020

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Class I histone deacetylase inhibition is synthetic lethal with BRCA1 deficiency in breast cancer cells.
Baoyuan Zhang, Junfang Lyu, Eun Ju Yang, Yifan Liu, Changjie Wu, Kaeling Tan

Acta Pharm Sin B· April 2020

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Combinatorial mutagenesis en masse optimizes the genome editing activities of SpCas9.
Gigi C G Choi, Peng Zhou, Chaya T L Yuen, Becky K C Chan, Feng Xu, Kaeling Tan

Nat Methods· August 2019

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Publisher Correction: Combinatorial mutagenesis en masse optimizes the genome editing activities of SpCas9.
Gigi C G Choi, Peng Zhou, Chaya T L Yuen, Becky K C Chan, Feng Xu, Kaeling Tan

Nat Methods· August 2019

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Universal plasmids to facilitate gene deletion and gene tagging in filamentous fungi.
Longguang Qin, Ang Li, Kaeling Tan, Shuhui Guo, Yingying Chen

Fungal Genet Biol· April 2019

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RNA polymerase II ChIP-seq-a powerful and highly affordable method for studying fungal genomics and physiology.
Kaeling Tan, Koon Ho Wong

Biophys Rev· February 2019

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BRCA1 deficiency sensitizes breast cancer cells to bromodomain and extra-terminal domain (BET) inhibition.
Baoyuan Zhang, Junfang Lyu, Yifan Liu, Changjie Wu, Eun Ju Yang, Kaeling Tan

Oncogene· December 2018

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PTEN deficiency confers colorectal cancer cell resistance to dual inhibitors of FLT3 and aurora kinase A.
Yifan Liu, Eun Ju Yang, Baoyuan Zhang, Zhengqiang Miao, Changjie Wu, Kaeling Tan

Cancer Lett· November 2018

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Tuning Hsf1 levels drives distinct fungal morphogenetic programs with depletion impairing Hsp90 function and overexpression expanding the target space.
Amanda O Veri, Zhengqiang Miao, Rebecca S Shapiro, Faiza Tebbji, Teresa R O'Meara, Kaeling Tan

PLoS Genet· March 2018

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The Candida albicans transcription factor Cas5 couples stress responses, drug resistance and cell cycle regulation.
Jinglin L Xie, Longguang Qin, Zhengqiang Miao, Ben T Grys, Jacinto De La Cruz Diaz, Kaeling Tan

Nat Commun· September 2017

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