Publications by authors named "Kamil Paruch"

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CDK7-CDK11 axis in spliceosome regulation and pre-mRNA splicing.
Michal Rájecký, Pavla Gajdušková, Peter Maník, Milan Hluchý, Eva Hegedűsová, Kamil Paruch

Nucleic Acids Res· November 2025

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Discovery of new inhibitors of nuclease MRE11.
Fedor Nikulenkov, Benoit Carbain, Raktim Biswas, Stepan Havel, Jana Prochazkova, Kamil Paruch

Eur J Med Chem· March 2025

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Thieno[3,2-b]pyridine: Attractive scaffold for highly selective inhibitors of underexplored protein kinases with variable binding mode.
Paula Martín Moyano, Tadeáš Kubina, Štěpán Owen Paruch, Aneta Jarošková, Jan Novotný, Kamil Paruch

Angew Chem Int Ed Engl· January 2025

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Unexpectedly Regioselective Diels-Alder Reactions of New Unsymmetrical Benzoquinones: A Convenient Synthetic Entry to Uniquely Substituted Decalins.
Lukáš Maier, Dana Němečková, Naresh Akavaram, Erik Kalla, Hugo Semrád, Kamil Paruch

Chemistry· October 2024

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Discovery of Two Highly Selective Structurally Orthogonal Chemical Probes for Activin Receptor-like Kinases 1 and 2.
Václav Němec, Marek Remeš, Petr Beňovský, Michael C Böck, Eliška Šranková, Kamil Paruch

J Med Chem· August 2024

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Inhibition of Chk1 stimulates cytotoxic action of platinum-based drugs and TRAIL combination in human prostate cancer cells.
Martin Krkoška, Kamil Paruch, Tereza Šošolíková, Gerardo Vázquez-Gómez, Jarmila Herůdková

Biol Chem· June 2024

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Discovery of Potent and Exquisitely Selective Inhibitors of Kinase CK1 with Tunable Isoform Selectivity.
Václav Němec, Prashant Khirsariya, Pavlína Janovská, Paula Martín Moyano, Lukáš Maier, Kamil Paruch

Angew Chem Int Ed Engl· March 2023

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Convergent Assembly of the Tricyclic Labdane Core Enables Synthesis of Diverse Forskolin-like Molecules.
Paweł M Szczepanik, Andrey A Mikhaylov, Ondřej Hylse, Roman Kučera, Petra Daďová, Kamil Paruch

Angew Chem Int Ed Engl· January 2023

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Author Correction: Characterization of an RNA binding protein interactome reveals a context-specific post-transcriptional landscape of MYC-amplified medulloblastoma.
Michelle M Kameda-Smith, Helen Zhu, En-Ching Luo, Yujin Suk, Agata Xella, Kamil Paruch

Nat Commun· January 2023

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Comparing the efficiency of six clearing methods in developing seeds of Arabidopsis thaliana.
Venkata Pardha Saradhi Attuluri, Juan Francisco Sánchez López, Lukáš Maier, Kamil Paruch, Hélène S Robert

Plant Reprod· December 2022

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Characterization of an RNA binding protein interactome reveals a context-specific post-transcriptional landscape of MYC-amplified medulloblastoma.
Michelle M Kameda-Smith, Helen Zhu, En-Ching Luo, Yujin Suk, Agata Xella, Kamil Paruch

Nat Commun· December 2022

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Geometric Control of Cell Behavior by Biomolecule Nanodistribution.
Jakub Pospíšil, Miloš Hrabovský, Dáša Bohačiaková, Zuzana Hovádková, Miroslav Jurásek, Kamil Paruch

ACS Biomater Sci Eng· November 2022

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CDK11 regulates pre-mRNA splicing by phosphorylation of SF3B1.
Milan Hluchý, Pavla Gajdušková, Igor Ruiz de Los Mozos, Michal Rájecký, Michael Kluge, Kamil Paruch

Nature· September 2022

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Synthesis and Profiling of Highly Selective Inhibitors of Methyltransferase DOT1L Based on Carbocyclic C-Nucleosides.
Prashant Khirsariya, Patrik Pospíšil, Lukáš Maier, Miroslav Boudný, Martin Babáš, Kamil Paruch

J Med Chem· April 2022

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Highly selective inhibitors of protein kinases CLK and HIPK with the furo[3,2-b]pyridine core.
Václav Němec, Lukáš Maier, Benedict-Tilman Berger, Apirat Chaikuad, Stanislav Drápela, Kamil Paruch

Eur J Med Chem· April 2021

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Cytoprotective activities of kinetin purine isosteres.
Barbara Maková, Václav Mik, Barbora Lišková, Gabriel Gonzalez, Dominik Vítek, Kamil Paruch

Bioorg Med Chem· March 2021

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The CHK1 inhibitor MU380 significantly increases the sensitivity of human docetaxel-resistant prostate cancer cells to gemcitabine through the induction of mitotic catastrophe.
Stanislav Drápela, Prashant Khirsariya, Wytske M van Weerden, Radek Fedr, Tereza Suchánková, Kamil Paruch

Mol Oncol· October 2020

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Cdc-Like Kinases (CLKs): Biology, Chemical Probes, and Therapeutic Potential.
Paula Martín Moyano, Václav Němec, Kamil Paruch

Int J Mol Sci· October 2020

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Novel CHK1 inhibitor MU380 exhibits significant single-agent activity in TP53-mutated chronic lymphocytic leukemia cells.
Miroslav Boudny, Jana Zemanova, Prashant Khirsariya, Marek Borsky, Jan Verner, Kamil Paruch

Haematologica· December 2019

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CDK12 controls G1/S progression by regulating RNAPII processivity at core DNA replication genes.
Anil Paul Chirackal Manavalan, Kveta Pilarova, Michael Kluge, Koen Bartholomeeusen, Michal Rajecky, Kamil Paruch

EMBO Rep· September 2019

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EU-OPENSCREEN: A Novel Collaborative Approach to Facilitate Chemical Biology.
Philip Brennecke, Dace Rasina, Oscar Aubi, Katja Herzog, Johannes Landskron, Kamil Paruch

SLAS Discov· March 2019

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Furo[3,2-b]pyridine: A Privileged Scaffold for Highly Selective Kinase Inhibitors and Effective Modulators of the Hedgehog Pathway.
Václav Němec, Michaela Hylsová, Lukáš Maier, Jana Flegel, Sonja Sievers, Kamil Paruch

Angew Chem Int Ed Engl· January 2019

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Preparation of 3,4-Substituted-5-Aminopyrazoles and 4-Substituted-2-Aminothiazoles.
Stepan Havel, Prashant Khirsariya, Naresh Akavaram, Kamil Paruch, Benoit Carbain

J Org Chem· December 2018

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Impact of the access tunnel engineering on catalysis is strictly ligand-specific.
Shubhangi Kaushik, Sérgio M Marques, Prashant Khirsariya, Kamil Paruch, Lenka Libichova

FEBS J· April 2018

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BRCA1 or CDK12 loss sensitizes cells to CHK1 inhibitors.
Hana Paculová, Juraj Kramara, Šárka Šimečková, Radek Fedr, Karel Souček, Kamil Paruch

Tumour Biol· October 2017

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