Publications by authors named "Kandasamy Pachamuthu"

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Preclinical evaluation of stereopure antisense oligonucleotides for allele-selective lowering of mutant .
Naoki Iwamoto, Yuanjing Liu, Maria Frank-Kamenetsky, Abbie Maguire, Wei Chou Tseng, Pachamuthu Kandasamy

Mol Ther Nucleic Acids· September 2024

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Rational design of base, sugar and backbone modifications improves ADAR-mediated RNA editing.
Genliang Lu, Chikdu Shivalila, Prashant Monian, Hui Yu, Ian Harding, Pachamuthu Kandasamy

Nucleic Acids Res· September 2024

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Impact of stereopure chimeric backbone chemistries on the potency and durability of gene silencing by RNA interference.
Wei Liu, Naoki Iwamoto, Subramanian Marappan, Khoa Luu, Snehlata Tripathi, Pachamuthu Kandasamy

Nucleic Acids Res· May 2023

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Metabolically Stable Anomeric Linkages Containing GalNAc-siRNA Conjugates: An Interplay among ASGPR, Glycosidase, and RISC Pathways.
Pachamuthu Kandasamy, Shohei Mori, Shigeo Matsuda, Namrata Erande, Dhrubajyoti Datta

J Med Chem· February 2023

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Endogenous ADAR-mediated RNA editing in non-human primates using stereopure chemically modified oligonucleotides.
Prashant Monian, Chikdu Shivalila, Genliang Lu, Mamoru Shimizu, David Boulay, Pachamuthu Kandasamy

Nat Biotechnol· July 2022

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Control of backbone chemistry and chirality boost oligonucleotide splice switching activity.
Pachamuthu Kandasamy, Graham McClorey, Mamoru Shimizu, Nayantara Kothari, Rowshon Alam

Nucleic Acids Res· June 2022

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Impact of guanidine-containing backbone linkages on stereopure antisense oligonucleotides in the CNS.
Pachamuthu Kandasamy, Yuanjing Liu, Vincent Aduda, Sandheep Akare, Rowshon Alam

Nucleic Acids Res· June 2022

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Quantitative Measurement of Cytosolic and Nuclear Penetration of Oligonucleotide Therapeutics.
Kirsten Deprey, Nefeli Batistatou, Marjoke F Debets, Jack Godfrey, Kirstin B VanderWall, Pachamuthu Kandasamy

ACS Chem Biol· February 2022

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Variant-selective stereopure oligonucleotides protect against pathologies associated with C9orf72-repeat expansion in preclinical models.
Yuanjing Liu, Jean-Cosme Dodart, Helene Tran, Shaunna Berkovitch, Maurine Braun, Pachamuthu Kandasamy

Nat Commun· February 2021

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Stereochemistry Enhances Potency, Efficacy, and Durability of Antisense Oligonucleotides In Vitro and In Vivo in Multiple Species.
Michael Byrne, Vinod Vathipadiekal, Luciano Apponi, Naoki Iwamoto, Pachamuthu Kandasamy

Transl Vis Sci Technol· January 2021

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siRNA conjugates carrying sequentially assembled trivalent N-acetylgalactosamine linked through nucleosides elicit robust gene silencing in vivo in hepatocytes.
Shigeo Matsuda, Kristofer Keiser, Jayaprakash K Nair, Klaus Charisse, Rajar M Manoharan, Pachamuthu Kandasamy

ACS Chem Biol· May 2015

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An RNAi therapeutic targeting antithrombin to rebalance the coagulation system and promote hemostasis in hemophilia.
Alfica Sehgal, Scott Barros, Lacramioara Ivanciu, Brian Cooley, June Qin, Pachamuthu Kandasamy

Nat Med· May 2015

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Multivalent N-acetylgalactosamine-conjugated siRNA localizes in hepatocytes and elicits robust RNAi-mediated gene silencing.
Jayaprakash K Nair, Jennifer L S Willoughby, Amy Chan, Klaus Charisse, Md Rowshon Alam, Pachamuthu Kandasamy

J Am Chem Soc· December 2014

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Biodegradable lipids enabling rapidly eliminated lipid nanoparticles for systemic delivery of RNAi therapeutics.
Martin A Maier, Muthusamy Jayaraman, Shigeo Matsuda, Ju Liu, Scott Barros, Pachamuthu Kandasamy

Mol Ther· August 2013

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Structure-based design, synthesis and A-site rRNA co-crystal complexes of novel amphiphilic aminoglycoside antibiotics with new binding modes: a synergistic hydrophobic effect against resistant bacteria.
Stephen Hanessian, Kandasamy Pachamuthu, Janek Szychowski, Alexandre Giguère, Eric E Swayze

Bioorg Med Chem Lett· December 2010

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Crystal structure of the bacterial ribosomal decoding site complexed with a synthetic doubly functionalized paromomycin derivative: a new specific binding mode to an a-minor motif enhances in vitro antibacterial activity.
Jiro Kondo, Kandasamy Pachamuthu, Boris François, Janek Szychowski, Stephen Hanessian

ChemMedChem· November 2007

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Structure-based design, synthesis, and A-site rRNA cocrystal complexes of functionally novel aminoglycoside antibiotics: C2" ether analogues of paromomycin.
Stephen Hanessian, Janek Szychowski, Susanta Sekhar Adhikari, Guillermo Vasquez, Pachamuthu Kandasamy

J Med Chem· May 2007

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Synthetic routes to thiooligosaccharides and thioglycopeptides.
Kandasamy Pachamuthu, Richard R Schmidt

Chem Rev· January 2006

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Reversed approach to S-farnesylation and S-palmitoylation: application to an efficient synthesis of the C-terminus of lipidated human N-ras hexapeptide.
Kandasamy Pachamuthu, Xiangming Zhu, Richard R Schmidt

J Org Chem· April 2005

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Antibacterial aminoglycosides with a modified mode of binding to the ribosomal-RNA decoding site.
Boris François, Janek Szychowski, Susanta Sekhar Adhikari, Kandasamy Pachamuthu, Eric E Swayze

Angew Chem Int Ed Engl· December 2004

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Straightforward synthesis of gem-phosphonate-phosphate containing compounds via one-pot reaction of thioesters with diethyl phosphite.
Kandasamy Pachamuthu, Richard R Schmidt

Chem Commun (Camb)· May 2004

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Synthesis of novel S-neoglycopeptides from glycosylthiomethyl derivatives.
Xiangming Zhu, Kandasamy Pachamuthu, Richard R Schmidt

Org Lett· April 2004

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Synthesis of S-linked glycopeptides in aqueous solution.
Xiangming Zhu, Kandasamy Pachamuthu, Richard R Schmidt

J Org Chem· July 2003

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