Publications by authors named "Karen Flatten"

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Codon specific readthrough as a mechanism of BRCA2 restoration in acquired PARP inhibitor and chemotherapy resistance.
Cordelia D McGehee, X Wei Meng, Xinyan Wu, Cristina Correia, Annapoorna Venkatachalam, Karen S Flatten

Nucleic Acids Res· October 2025

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CHFR expression and sensitivity of breast cancer cells to antimitotic agents in vitro and in the I-SPY trial.
Andrea E Wahner Hendrickson, Karen S Flatten, Taylor M Weiskittel, Annapoorna Venkatachalam, Annabella R Strathman

NPJ Breast Cancer· October 2025

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Proapoptotic activity of JNK-sensitive BH3-only proteins underpins ovarian cancer response to replication checkpoint inhibitors.
Annapoorna Venkatachalam, Cristina Correia, Kevin L Peterson, Xianon Hou, Paula A Schneider, Karen S Flatten

Mol Cancer· October 2024

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A phase I study of pevonedistat, azacitidine, and venetoclax in patients with relapsed/refractory acute myeloid leukemia.
Guru Subramanian Guru Murthy, Antoine N Saliba, Aniko Szabo, Alexandra Harrington, Sameem Abedin, Karen S Flatten

Haematologica· September 2024

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AMPK inhibition sensitizes acute leukemia cells to BH3 mimetic-induced cell death.
Jia Jia, Wenbo Ji, Antoine N Saliba, Clifford M Csizmar, Kaiqin Ye, Karen S Flatten

Cell Death Differ· April 2024

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A phase 2 and pharmacological study of sapanisertib in patients with relapsed and/or refractory acute lymphoblastic leukemia.
Aref Al-Kali, Ibrahim Aldoss, Pamela J Atherton, Carrie A Strand, Bijal Shah, Karen S Flatten

Cancer Med· December 2023

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A BAK subdomain that binds mitochondrial lipids selectively and releases cytochrome C.
Haiming Dai, Kevin L Peterson, Karen S Flatten, X Wei Meng, Annapoorna Venkatachalam

Cell Death Differ· March 2023

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CHFR and Paclitaxel Sensitivity of Ovarian Cancer.
Andrea E Wahner Hendrickson, Daniel W Visscher, Xiaonan Hou, Krista M Goergen, Hunter J Atkinson, Karen S Flatten

Cancers (Basel)· November 2021

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Fatty acid synthase (FASN) regulates the mitochondrial priming of cancer cells.
Barbara Schroeder, Travis Vander Steen, Ingrid Espinoza, Chandra M Kurapaty Venkatapoorna, Zeng Hu, Karen S Flatten

Cell Death Dis· October 2021

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Characterization of a -silenced high-grade serous ovarian cancer model during development of PARP inhibitor resistance.
Rachel M Hurley, Cordelia D McGehee, Ksenija Nesic, Cristina Correia, Taylor M Weiskittel, Karen S Flatten

NAR Cancer· September 2021

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CDK2-Mediated Upregulation of TNFα as a Mechanism of Selective Cytotoxicity in Acute Leukemia.
Husheng Ding, Nicole D Vincelette, Cordelia D McGehee, Mira A Kohorst, Brian D Koh, Karen S Flatten

Cancer Res· May 2021

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53BP1 as a potential predictor of response in PARP inhibitor-treated homologous recombination-deficient ovarian cancer.
Rachel M Hurley, Andrea E Wahner Hendrickson, Daniel W Visscher, Peter Ansell, Maria I Harrell, Karen S Flatten

Gynecol Oncol· April 2019

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Effect of CHK1 Inhibition on CPX-351 Cytotoxicity in vitro and ex vivo.
Nicole D Vincelette, Husheng Ding, Amelia M Huehls, Karen S Flatten, Rebecca L Kelly

Sci Rep· March 2019

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A Phase I Clinical Trial of the Poly(ADP-ribose) Polymerase Inhibitor Veliparib and Weekly Topotecan in Patients with Solid Tumors.
Andrea E Wahner Hendrickson, Michael E Menefee, Lynn C Hartmann, Harry J Long, Donald W Northfelt, Karen S Flatten

Clin Cancer Res· February 2018

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Spartan deficiency causes accumulation of Topoisomerase 1 cleavage complexes and tumorigenesis.
Reeja S Maskey, Karen S Flatten, Cynthia J Sieben, Kevin L Peterson, Darren J Baker

Nucleic Acids Res· May 2017

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In vivo anti-tumor activity of the PARP inhibitor niraparib in homologous recombination deficient and proficient ovarian carcinoma.
Mariam M AlHilli, Marc A Becker, S John Weroha, Karen S Flatten, Rachel M Hurley

Gynecol Oncol· November 2016

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Poly (ADP-Ribose) Polymerase Inhibitor Hypersensitivity in Aggressive Myeloproliferative Neoplasms.
Keith W Pratz, Brian D Koh, Anand G Patel, Karen S Flatten, Weijie Poh

Clin Cancer Res· August 2016

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4EBP1/c-MYC/PUMA and NF-κB/EGR1/BIM pathways underlie cytotoxicity of mTOR dual inhibitors in malignant lymphoid cells.
Seongseok Yun, Nicole D Vincelette, Katherine L B Knorr, Luciana L Almada, Paula A Schneider, Karen S Flatten

Blood· June 2016

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Immunodetection of human topoisomerase I-DNA covalent complexes.
Anand G Patel, Karen S Flatten, Kevin L Peterson, Thomas G Beito, Paula A Schneider

Nucleic Acids Res· April 2016

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Synthesis of a peptide-universal nucleotide antigen: towards next-generation antibodies to detect topoisomerase I-DNA covalent complexes.
Angela L Perkins, Kevin L Peterson, Thomas G Beito, Karen S Flatten, Scott H Kaufmann

Org Biomol Chem· April 2016

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Poly(ADP-ribose) polymerase inhibitors sensitize cancer cells to death receptor-mediated apoptosis by enhancing death receptor expression.
X Wei Meng, Brian D Koh, Jin-San Zhang, Karen S Flatten, Paula A Schneider

J Biol Chem· July 2014

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Context-dependent antagonism between Akt inhibitors and topoisomerase poisons.
Marina Gálvez-Peralta, Karen S Flatten, David A Loegering, Kevin L Peterson, Paula A Schneider

Mol Pharmacol· May 2014

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CHK1 and WEE1 inhibition combine synergistically to enhance therapeutic efficacy in acute myeloid leukemia ex vivo.
Leena Chaudhuri, Nicole D Vincelette, Brian D Koh, Ryan M Naylor, Karen S Flatten

Haematologica· April 2014

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Farnesyltransferase inhibitor tipifarnib inhibits Rheb prenylation and stabilizes Bax in acute myelogenous leukemia cells.
Husheng Ding, Jennifer S McDonald, Seongseok Yun, Paula A Schneider, Kevin L Peterson, Karen S Flatten

Haematologica· January 2014

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ATR inhibition broadly sensitizes ovarian cancer cells to chemotherapy independent of BRCA status.
Catherine J Huntoon, Karen S Flatten, Andrea E Wahner Hendrickson, Amelia M Huehls, Shari L Sutor

Cancer Res· June 2013

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