Publications by authors named "Karena Last"

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Inhibition of heme biosynthesis triggers cuproptosis in acute myeloid leukemia.
Alexander C Lewis, Emily Gruber, Rheana Franich, Jessica Armstrong, Madison J Kelly, Karena Last

Cell· November 2025

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Complex II assembly drives metabolic adaptation to OXPHOS dysfunction.
Roopasingam Kugapreethan, Sheik Nadeem Elahee Doomun, Joanna Sacharz, Ann E Frazier, Tanavi Sharma, Karena Last

Sci Adv· August 2025

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ADAMTS-9 in Mouse Cartilage Has Aggrecanase Activity That Is Distinct from ADAMTS-4 and ADAMTS-5.
Fraser M Rogerson, Karena Last, Suzanne B Golub, Stephanie J Gauci, Heather Stanton

Int J Mol Sci· January 2019

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An aggrecan fragment drives osteoarthritis pain through Toll-like receptor 2.
Rachel E Miller, Shingo Ishihara, Phuong B Tran, Suzanne B Golub, Karena Last

JCI Insight· March 2018

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A Disintegrin and Metalloproteinase with Thrombospondin Motifs-5 (ADAMTS-5) Forms Catalytically Active Oligomers.
Hansen J Kosasih, Karena Last, Fraser M Rogerson, Suzanne B Golub, Stephanie J Gauci

J Biol Chem· February 2016

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Bioactivity in an Aggrecan 32-mer Fragment Is Mediated via Toll-like Receptor 2.
Sophie Lees, Suzanne B Golub, Karena Last, Weiguang Zeng, David C Jackson

Arthritis Rheumatol· May 2015

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Aggrecanase cleavage in juvenile idiopathic arthritis patients is minimally detected in the aggrecan interglobular domain but robust at the aggrecan C-terminus.
André Struglics, L Stefan Lohmander, Karena Last, Jonathan Akikusa, Roger Allen

Arthritis Rheum· December 2012

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Evidence for lysosomal exocytosis and release of aggrecan-degrading hydrolases from hypertrophic chondrocytes, in vitro and in vivo.
Edward R Bastow, Karena Last, Sue Golub, Jennifer L Stow, Amanda C Stanley

Biol Open· April 2012

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Investigating ADAMTS-mediated aggrecanolysis in mouse cartilage.
Heather Stanton, Suzanne B Golub, Fraser M Rogerson, Karena Last, Christopher B Little

Nat Protoc· March 2011

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Cytokine-induced increases in ADAMTS-4 messenger RNA expression do not lead to increased aggrecanase activity in ADAMTS-5-deficient mice.
Fraser M Rogerson, Yuen M Chung, Michael E Deutscher, Karena Last, Amanda J Fosang

Arthritis Rheum· November 2010

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Neoepitope antibodies against MMP-cleaved and aggrecanase-cleaved aggrecan.
Amanda J Fosang, Karena Last, Heather Stanton, Suzanne B Golub, Christopher B Little

Methods Mol Biol· April 2010

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N-linked keratan sulfate in the aggrecan interglobular domain potentiates aggrecanase activity.
Christopher J Poon, Anna H Plaas, Doug R Keene, David J McQuillan, Karena Last

J Biol Chem· June 2005

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Matrix metalloproteinases are not essential for aggrecan turnover during normal skeletal growth and development.
Christopher B Little, Clare T Meeker, Rosalind M Hembry, Natalie A Sims, Kate E Lawlor, Karena Last

Mol Cell Biol· April 2005

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ADAMTS5 is the major aggrecanase in mouse cartilage in vivo and in vitro.
Heather Stanton, Fraser M Rogerson, Charlotte J East, Suzanne B Golub, Kate E Lawlor, Karena Last

Nature· March 2005

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ADAMTS4 cleaves at the aggrecanase site (Glu373-Ala374) and secondarily at the matrix metalloproteinase site (Asn341-Phe342) in the aggrecan interglobular domain.
Jennifer Westling, Amanda J Fosang, Karena Last, Vivian P Thompson, Kathy N Tomkinson

J Biol Chem· May 2002

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