Publications by authors named "Karim Azer"

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The Advancing the Development of Pediatric Therapeutics 8 (ADEPT 8) Workshop on Drug Dosing in Pediatric Patients with Renal Impairment.
Shamir Tuchman, Yeruk Mulugeta, George J Schwartz, Guido Filler, Saskia N de Wildt, Karim Azer

J Pediatr· August 2025

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Unlocking the Mysteries of Rare Disease Drug Development: A Beginner's Guide for Clinical Pharmacologists.
Mariam A Ahmed, Bilal AbuAsal, Jeffrey S Barrett, Karim Azer, Yuen Yi Hon

Clin Transl Sci· April 2025

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H and P MR Spectroscopy to Assess Muscle Mitochondrial Dysfunction in Long COVID.
Lucy E M Finnigan, Mark Philip Cassar, Mehrsa Jafarpour, Antonella Sultana, Zakariye Ashkir, Karim Azer

Radiology· December 2024

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Advancing precision medicine therapeutics for Parkinson's utilizing a shared quantitative systems pharmacology model and framework.
Christopher Denaro, Diane Stephenson, Martijn L T M Müller, Benedetto Piccoli, Karim Azer

Front Syst Biol· March 2024

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A minimal PBPK model to accelerate preclinical development of drugs against tuberculosis.
Federico Reali, Anna Fochesato, Chanchala Kaddi, Roberto Visintainer, Shayne Watson, Karim Azer

Front Pharmacol· January 2024

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Systems biology platform for efficient development and translation of multitargeted therapeutics.
Karim Azer, Irina Leaf

Front Syst Biol· September 2023

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A pipeline for testing drug mechanism of action and combination therapies: From microarray data to simulations via Linear-In-Flux-Expressions: Testing four-drug combinations for tuberculosis treatment.
Christopher Denaro, Nathaniel J Merrill, Sean T McQuade, Logan Reed, Karim Azer

Math Biosci· June 2023

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Opportunities for Systems Biology and Quantitative Systems Pharmacology to Address Knowledge Gaps for Drug Development in Pregnancy.
Jeffrey S Barrett, Karim Azer

J Clin Pharmacol· June 2023

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Efficacy and tolerability of an endogenous metabolic modulator (AXA1125) in fatigue-predominant long COVID: a single-centre, double-blind, randomised controlled phase 2a pilot study.
Lucy E M Finnigan, Mark Philip Cassar, Margaret James Koziel, Joel Pradines, Hanan Lamlum, Karim Azer

EClinicalMedicine· May 2023

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Role of Disease Progression Models in Drug Development.
Jeffrey S Barrett, Tim Nicholas, Karim Azer, Brian W Corrigan

Pharm Res· August 2022

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Quantitative system pharmacology as a legitimate approach to examine extrapolation strategies used to support pediatric drug development.
Karim Azer, Jeffrey S Barrett

CPT Pharmacometrics Syst Pharmacol· July 2022

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QSPcc reduces bottlenecks in computational model simulations.
Danilo Tomasoni, Alessio Paris, Stefano Giampiccolo, Federico Reali, Giulia Simoni, Karim Azer

Commun Biol· September 2021

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Reconstruction of the Cytokine Signaling in Lysosomal Storage Diseases by Literature Mining and Network Analysis.
Silvia Parolo, Danilo Tomasoni, Pranami Bora, Alan Ramponi, Chanchala Kaddi, Karim Azer

Front Cell Dev Biol· August 2021

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A robust computational pipeline for model-based and data-driven phenotype clustering.
Giulia Simoni, Chanchala Kaddi, Mengdi Tao, Federico Reali, Danilo Tomasoni, Karim Azer

Bioinformatics· June 2021

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History and Future Perspectives on the Discipline of Quantitative Systems Pharmacology Modeling and Its Applications.
Karim Azer, Chanchala D Kaddi, Jeffrey S Barrett, Jane P F Bai, Sean T McQuade

Front Physiol· March 2021

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A Quantitative Systems Pharmacology Model of Gaucher Disease Type 1 Provides Mechanistic Insight Into the Response to Substrate Reduction Therapy With Eliglustat.
Ruth Abrams, Chanchala D Kaddi, Mengdi Tao, Randolph J Leiser, Giulia Simoni, Karim Azer

CPT Pharmacometrics Syst Pharmacol· July 2020

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Quantitative Systems Pharmacology Modeling of Acid Sphingomyelinase Deficiency and the Enzyme Replacement Therapy Olipudase Alfa Is an Innovative Tool for Linking Pathophysiology and Pharmacology.
Chanchala D Kaddi, Bradley Niesner, Rena Baek, Paul Jasper, John Pappas, Karim Azer

CPT Pharmacometrics Syst Pharmacol· July 2018

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Linear-In-Flux-Expressions Methodology: Toward a Robust Mathematical Framework for Quantitative Systems Pharmacology Simulators.
Sean T McQuade, Ruth E Abrams, Jeffrey S Barrett, Benedetto Piccoli, Karim Azer

Gene Regul Syst Bio· July 2017

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A Quantitative Systems Pharmacology Platform to Investigate the Impact of Alirocumab and Cholesterol-Lowering Therapies on Lipid Profiles and Plaque Characteristics.
Jeffrey E Ming, Ruth E Abrams, Derek W Bartlett, Mengdi Tao, Tu Nguyen, Karim Azer

Gene Regul Syst Bio· June 2017

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Discovery and Clinical Evaluation of MK-8150, A Novel Nitric Oxide Donor With a Unique Mechanism of Nitric Oxide Release.
Clayton D Knox, Pieter-Jan de Kam, Karim Azer, Peggy Wong, Antwan G Ederveen

J Am Heart Assoc· August 2016

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Quantifying cholesterol synthesis in vivo using (2)H(2)O: enabling back-to-back studies in the same subject.
Stephen F Previs, Ablatt Mahsut, Alison Kulick, Keiana Dunn, Genevieve Andrews-Kelly, Karim Azer

J Lipid Res· July 2011

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A novel 3-dimensional micro-ultrasound approach to automated measurement of carotid arterial plaque volume as a biomarker for experimental atherosclerosis.
Matthew Walker, Barry R Campbell, Karim Azer, Christopher Tong, Kaijie Fang

Atherosclerosis· May 2009

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Segmentation of arterial vessel wall motion to sub-pixel resolution using M-mode ultrasound.
Craig Fancourt, Karim Azer, Sharmilee L Ramcharan, Michelle Bunzel, Barry R Cambell

Annu Int Conf IEEE Eng Med Biol Soc· April 2009

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A one-dimensional model of blood flow in arteries with friction and convection based on the Womersley velocity profile.
Karim Azer, Charles S Peskin

Cardiovasc Eng· June 2007

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A cell-sparing electric field stimulation technique for high-throughput screening of voltage-gated ion channels.
Randal M Bugianesi, Paul R Augustine, Karim Azer, Claude Dufresne, James Herrington

Assay Drug Dev Technol· February 2006

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