Publications by authors named "Karl A Merrick"

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An RNA damage response network mediates the lethality of 5-FU in colorectal cancer.
Jung-Kuei Chen, Karl A Merrick, Yi Wen Kong, Anita Izrael-Tomasevic, George Eng

Cell Rep Med· October 2024

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An RNA Damage Response Network Mediates the Lethality of 5-FU in Clinically Relevant Tumor Types.
Jung-Kuei Chen, Karl A Merrick, Yi Wen Kong, Anita Izrael-Tomasevic, George Eng

bioRxiv· April 2023

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Design of a brain-penetrant CDK4/6 inhibitor for glioblastoma.
Sarah M Bronner, Karl A Merrick, Jeremy Murray, Laurent Salphati, John G Moffat

Bioorg Med Chem Lett· August 2019

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MK2 contributes to tumor progression by promoting M2 macrophage polarization and tumor angiogenesis.
Lucia Suarez-Lopez, Ganapathy Sriram, Yi Wen Kong, Sandra Morandell, Karl A Merrick

Proc Natl Acad Sci U S A· May 2018

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A Pleiotropic RNA-Binding Protein Controls Distinct Cell Cycle Checkpoints to Drive Resistance of p53-Defective Tumors to Chemotherapy.
Ian G Cannell, Karl A Merrick, Sandra Morandell, Chang-Qi Zhu, Christian J Braun

Cancer Cell· December 2015

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A Pleiotropic RNA-Binding Protein Controls Distinct Cell Cycle Checkpoints to Drive Resistance of p53-Defective Tumors to Chemotherapy.
Ian G Cannell, Karl A Merrick, Sandra Morandell, Chang-Qi Zhu, Christian J Braun

Cancer Cell· November 2015

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A Cdk7-Cdk4 T-loop phosphorylation cascade promotes G1 progression.
Miriam Merzel Schachter, Karl A Merrick, Stéphane Larochelle, Alexander Hirschi, Chao Zhang

Mol Cell· April 2013

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Chemical genetics reveals a specific requirement for Cdk2 activity in the DNA damage response and identifies Nbs1 as a Cdk2 substrate in human cells.
Lara Wohlbold, Karl A Merrick, Saurav De, Ramon Amat, Jun Hyun Kim

PLoS Genet· August 2012

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Why minimal is not optimal: driving the mammalian cell cycle--and drug discovery--with a physiologic CDK control network.
Karl A Merrick, Robert P Fisher

Cell Cycle· July 2012

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Chemical-genetic analysis of cyclin dependent kinase 2 function reveals an important role in cellular transformation by multiple oncogenic pathways.
Dai Horiuchi, Noelle E Huskey, Leonard Kusdra, Lara Wohlbold, Karl A Merrick

Proc Natl Acad Sci U S A· April 2012

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Switching Cdk2 on or off with small molecules to reveal requirements in human cell proliferation.
Karl A Merrick, Lara Wohlbold, Chao Zhang, Jasmina J Allen, Dai Horiuchi

Mol Cell· June 2011

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A virtual cycle: theory and experiment converge on the exit from mitosis.
Karl A Merrick, Robert P Fisher

F1000 Biol Rep· May 2010

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Putting one step before the other: distinct activation pathways for Cdk1 and Cdk2 bring order to the mammalian cell cycle.
Karl A Merrick, Robert P Fisher

Cell Cycle· February 2010

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Distinct activation pathways confer cyclin-binding specificity on Cdk1 and Cdk2 in human cells.
Karl A Merrick, Stéphane Larochelle, Chao Zhang, Jasmina J Allen, Kevan M Shokat

Mol Cell· December 2008

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Picosecond-resolution fluorescence lifetime imaging microscopy: a useful tool for sensing molecular interactions in vivo via FRET.
Wei Zhong, Mei Wu, Ching-Wei Chang, Karl A Merrick, Sofia D Merajver

Opt Express· December 2007

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Requirements for Cdk7 in the assembly of Cdk1/cyclin B and activation of Cdk2 revealed by chemical genetics in human cells.
Stéphane Larochelle, Karl A Merrick, Marie-Emilie Terret, Lara Wohlbold, Nora M Barboza

Mol Cell· March 2007

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