Publications by authors named "Karl Agger"

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WNK1 signalling regulates amino acid transport and mTORC1 activity to sustain acute myeloid leukaemia growth.
Shunlei Duan, Karl Agger, Jan-Erik Messling, Koutarou Nishimura, Xuerui Han

Nat Commun· May 2025

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ETV2/ER71 regulates hematovascular lineage generation and vascularization through an H3K9 demethylase, KDM4A.
Min Seong Kim, Raham Lee, Dong Hun Lee, Heesang Song, Taekyung Ha, Karl Agger

iScience· January 2025

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Inhibition of TOPORS ubiquitin ligase augments the efficacy of DNA hypomethylating agents through DNMT1 stabilization.
Satoshi Kaito, Kazumasa Aoyama, Motohiko Oshima, Akiho Tsuchiya, Makiko Miyota, Karl Agger

Nat Commun· August 2024

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TAK1 inhibition leads to RIPK1-dependent apoptosis in immune-activated cancers.
Helene Damhofer, Tülin Tatar, Benjamin Southgate, Scott Scarneo, Karl Agger

Cell Death Dis· April 2024

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Vitamin C activates young LINE-1 elements in mouse embryonic stem cells via H3K9me3 demethylation.
Kevin C L Cheng, Jennifer M Frost, Francisco J Sánchez-Luque, Marta García-Canãdas, Darren Taylor, Karl Agger

Epigenetics Chromatin· October 2023

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Targeting RIOK2 ATPase activity leads to decreased protein synthesis and cell death in acute myeloid leukemia.
Jan-Erik Messling, Karl Agger, Kasper L Andersen, Kristina Kromer, Hanna M Kuepper

Blood· January 2022

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The Lysine Demethylase KDM5B Regulates Islet Function and Glucose Homeostasis.
Marie Balslev Backe, Chunyu Jin, Luz Andreone, Aditya Sankar, Karl Agger

J Diabetes Res· January 2020

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The KDM4/JMJD2 histone demethylases are required for hematopoietic stem cell maintenance.
Karl Agger, Koutarou Nishimura, Satoru Miyagi, Jan-Erik Messling, Kasper Dindler Rasmussen

Blood· October 2019

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Jarid2 binds mono-ubiquitylated H2A lysine 119 to mediate crosstalk between Polycomb complexes PRC1 and PRC2.
Sarah Cooper, Anne Grijzenhout, Elizabeth Underwood, Katia Ancelin, Tianyi Zhang, Karl Agger

Nat Commun· November 2016

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Continual removal of H3K9 promoter methylation by Jmjd2 demethylases is vital for ESC self-renewal and early development.
Marianne Terndrup Pedersen, Susanne Marije Kooistra, Aliaksandra Radzisheuskaya, Anne Laugesen, Jens Vilstrup Johansen, Karl Agger

EMBO J· July 2016

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Jmjd2/Kdm4 demethylases are required for expression of Il3ra and survival of acute myeloid leukemia cells.
Karl Agger, Satoru Miyagi, Marianne Terndrup Pedersen, Susanne M Kooistra, Jens Vilstrup Johansen

Genes Dev· June 2016

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The demethylase JMJD2C localizes to H3K4me3-positive transcription start sites and is dispensable for embryonic development.
Marianne Terndrup Pedersen, Karl Agger, Anne Laugesen, Jens V Johansen, Paul A C Cloos

Mol Cell Biol· March 2014

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Histone lysine demethylases as targets for anticancer therapy.
Jonas W Højfeldt, Karl Agger, Kristian Helin

Nat Rev Drug Discov· December 2013

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Inhibitors of histone demethylases.
Brian Lohse, Jesper L Kristensen, Line H Kristensen, Karl Agger, Kristian Helin

Bioorg Med Chem· June 2011

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The H3K27me3 demethylase JMJD3 contributes to the activation of the INK4A-ARF locus in response to oncogene- and stress-induced senescence.
Karl Agger, Paul A C Cloos, Lise Rudkjaer, Kristine Williams, Gitte Andersen

Genes Dev· May 2009

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Erasing the methyl mark: histone demethylases at the center of cellular differentiation and disease.
Paul A C Cloos, Jesper Christensen, Karl Agger, Kristian Helin

Genes Dev· May 2008

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Coordinated regulation of transcriptional repression by the RBP2 H3K4 demethylase and Polycomb-Repressive Complex 2.
Diego Pasini, Klaus H Hansen, Jesper Christensen, Karl Agger, Paul A C Cloos

Genes Dev· May 2008

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The emerging functions of histone demethylases.
Karl Agger, Jesper Christensen, Paul A C Cloos, Kristian Helin

Curr Opin Genet Dev· April 2008

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UTX and JMJD3 are histone H3K27 demethylases involved in HOX gene regulation and development.
Karl Agger, Paul A C Cloos, Jesper Christensen, Diego Pasini, Simon Rose

Nature· October 2007

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RBP2 belongs to a family of demethylases, specific for tri-and dimethylated lysine 4 on histone 3.
Jesper Christensen, Karl Agger, Paul A C Cloos, Diego Pasini, Simon Rose

Cell· March 2007

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The putative oncogene GASC1 demethylates tri- and dimethylated lysine 9 on histone H3.
Paul A C Cloos, Jesper Christensen, Karl Agger, Alessio Maiolica, Juri Rappsilber

Nature· July 2006

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Conditional E2F1 activation in transgenic mice causes testicular atrophy and dysplasia mimicking human CIS.
Karl Agger, Eric Santoni-Rugiu, Christian Holmberg, Olle Karlström, Kristian Helin

Oncogene· January 2005

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A novel repressive E2F6 complex containing the polycomb group protein, EPC1, that interacts with EZH2 in a proliferation-specific manner.
Claire Attwooll, Sergio Oddi, Peter Cartwright, Elena Prosperini, Karl Agger

J Biol Chem· January 2005

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