Publications by authors named "Karthikeyani Chellappa"

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Age-related NAD decline.
Melanie R McReynolds, Karthikeyani Chellappa, Joseph A Baur

June 2020

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Loss of NAD Homeostasis Leads to Progressive and Reversible Degeneration of Skeletal Muscle.
David W Frederick, Emanuele Loro, Ling Liu, Antonio Davila, Karthikeyani Chellappa, Ian M Silverman, William J Quinn, Sager J Gosai, Elisia D Tichy, James G Davis

Cell Metab· August 2016

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Soybean Oil Is More Obesogenic and Diabetogenic than Coconut Oil and Fructose in Mouse: Potential Role for the Liver.
Poonamjot Deol, Jane R Evans, Joseph Dhahbi, Karthikeyani Chellappa, Diana S Han, Stephen Spindler, Frances M Sladek

April 2016

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Long-term NMN treatment increases lifespan and healthspan in mice in a sex dependent manner.
Alice E Kane, Karthikeyani Chellappa, Michael B Schultz, Matthew Arnold, Jien Li

bioRxiv· June 2024

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A subpopulation of lipogenic brown adipocytes drives thermogenic memory.
Patrick Lundgren, Prateek V Sharma, Lenka Dohnalová, Kyle Coleman, Giulia T Uhr, Karthikeyani Chellappa

Nat Metab· October 2023

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NAD precursor supplementation prevents mtRNA/RIG-I-dependent inflammation during kidney injury.
Tomohito Doke, Sarmistha Mukherjee, Dhanunjay Mukhi, Poonam Dhillon, Amin Abedini, Karthikeyani Chellappa

Nat Metab· March 2023

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NAD precursors cycle between host tissues and the gut microbiome.
Karthikeyani Chellappa, Melanie R McReynolds, Wenyun Lu, Xianfeng Zeng, Mikhail Makarov

Cell Metab· December 2022

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A microbiome-dependent gut-brain pathway regulates motivation for exercise.
Lenka Dohnalová, Patrick Lundgren, Jamie R E Carty, Nitsan Goldstein, Sebastian L Wenski, Karthikeyani Chellappa

Nature· December 2022

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NAD flux is maintained in aged mice despite lower tissue concentrations.
Melanie R McReynolds, Karthikeyani Chellappa, Eric Chiles, Connor Jankowski, Yihui Shen

Cell Syst· December 2021

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Reducing NAD(H) to amplify rhythms.
Karthikeyani Chellappa, Joseph A Baur

Nat Metab· December 2021

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SIRT3 is required for liver regeneration but not for the beneficial effect of nicotinamide riboside.
Sarmistha Mukherjee, James Mo, Lauren M Paolella, Caroline E Perry, Jade Toth, Karthikeyani Chellappa

JCI Insight· April 2021

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CD38 ecto-enzyme in immune cells is induced during aging and regulates NAD and NMN levels.
Claudia C S Chini, Thais R Peclat, Gina M Warner, Sonu Kashyap, Jair Machado Espindola-Netto, Karthikeyani Chellappa

Nat Metab· November 2020

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Rapamycin maintains NAD/NADH redox homeostasis in muscle cells.
Zhigang Zhang, He N Xu, Siyu Li, Antonio Davila Jr, Karthikeyani Chellappa

Aging (Albany NY)· September 2020

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mTORC1 restrains adipocyte lipolysis to prevent systemic hyperlipidemia.
Lauren M Paolella, Sarmistha Mukherjee, Cassie M Tran, Bruna Bellaver, Mindy Hugo, Karthikeyani Chellappa

Mol Metab· February 2020

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Hypothalamic mTORC2 is essential for metabolic health and longevity.
Karthikeyani Chellappa, Jacqueline A Brinkman, Sarmistha Mukherjee, Mark Morrison, Mohammed I Alotaibi

Aging Cell· October 2019

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The leptin sensitizer celastrol reduces age-associated obesity and modulates behavioral rhythms.
Karthikeyani Chellappa, Isaac J Perron, Nirinjini Naidoo, Joseph A Baur

Aging Cell· June 2019

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Optical Redox Imaging of Fixed Unstained Muscle Slides Reveals Useful Biological Information.
He N Xu, Huaqing Zhao, Karthikeyani Chellappa, James G Davis, Shoko Nioka

Mol Imaging Biol· June 2019

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Dietary challenges differentially affect activity and sleep/wake behavior in mus musculus: Isolating independent associations with diet/energy balance and body weight.
Isaac J Perron, Brendan T Keenan, Karthikeyani Chellappa, Nicholas F Lahens, Nicole L Yohn

PLoS One· August 2018

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Nicotinamide adenine dinucleotide is transported into mammalian mitochondria.
Antonio Davila, Ling Liu, Karthikeyani Chellappa, Philip Redpath, Eiko Nakamaru-Ogiso

Elife· June 2018

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Quantitative Analysis of NAD Synthesis-Breakdown Fluxes.
Ling Liu, Xiaoyang Su, William J Quinn, Sheng Hui, Kristin Krukenberg, Karthikeyani Chellappa

Cell Metab· May 2018

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Nicotinamide adenine dinucleotide biosynthesis promotes liver regeneration.
Sarmistha Mukherjee, Karthikeyani Chellappa, Andrea Moffitt, Joan Ndungu, Ryan W Dellinger

Hepatology· February 2017

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Opposing roles of nuclear receptor HNF4α isoforms in colitis and colitis-associated colon cancer.
Karthikeyani Chellappa, Poonamjot Deol, Jane R Evans, Linh M Vuong, Gang Chen

Elife· May 2016

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Differential Effects of Hepatocyte Nuclear Factor 4α Isoforms on Tumor Growth and T-Cell Factor 4/AP-1 Interactions in Human Colorectal Cancer Cells.
Linh M Vuong, Karthikeyani Chellappa, Joseph M Dhahbi, Jonathan R Deans, Bin Fang

Mol Cell Biol· October 2015

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HNF4α: a new biomarker in colon cancer?
Karthikeyani Chellappa, Graham R Robertson, Frances M Sladek

Biomark Med· June 2012

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Src tyrosine kinase phosphorylation of nuclear receptor HNF4α correlates with isoform-specific loss of HNF4α in human colon cancer.
Karthikeyani Chellappa, Lucy Jankova, Jake M Schnabl, Songqin Pan, Yann Brelivet

Proc Natl Acad Sci U S A· February 2012

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