Cell Metab August 2016 PMID 27508874

Loss of NAD Homeostasis Leads to Progressive and Reversible Degeneration of Skeletal Muscle.

David W Frederick, Emanuele Loro, Ling Liu, Antonio Davila, Karthikeyani Chellappa, Ian M Silverman, William J Quinn, Sager J Gosai, Elisia D Tichy, James G Davis, Foteini Mourkioti, Brian D Gregory, Ryan W Dellinger, Philip Redpath, Marie E Migaud

Download social card

Mentions

Peak: 2 in May 2024

across 5 sources since Sep 2016

Extended reach

141,120

potential audience

Total likes

125

Video views

12,980

Mentions per month

Sep 2016 – May 2024

Where it's discussed

News14 articles
Facebook6 posts
X / Twitter5 posts
Blogs4 articles
YouTube2 videos

AI synopsis

What people are saying

Discussions frequently highlight key experimental details, such as the knockout of NAMPT and the restoration of muscle function with nicotinamide riboside, often emphasizing the significance of NAD homeostasis for muscle health. The tone suggests excitement about the potential for reversing muscle degeneration, with phrases like 'restored ATP production' and 'reversible degeneration' underscoring the perceived importance of these findings.

AgreementModerate agreement

Most discussions support the findings, especially highlighting the role of NAMPT and NAD in muscle health, indicating general agreement with the research's implications.

InterestHigh interest

The discussions show high interest, with posts referencing specific experiments like NAMPT knockout and restoration using NR, demonstrating curiosity about mechanisms and potential treatments.

EngagementModerate engagement

Posts include mentions of technical details and implications, such as the effects on ATP production and muscle degeneration, reflecting active engagement.

ImpactModerate impact

The emphasis on potential reversibility and therapeutic approaches suggests that these findings could influence future research and treatment strategies, indicating moderate to high perceived impact.

Abstract in brief

NAD is crucial for breaking down metabolic fuels in all cells, but its availability decreases during aging and stress.
Researchers studied the impact of depleting Nampt (a key NAD-producing enzyme) in mice, finding that it led to a significant drop in NAD levels, muscle degeneration, and loss of strength.
Supplementing with nicotinamide riboside helped reverse some muscle function issues, and boosting Nampt expression over a lifetime helped maintain muscle health in older mice, highlighting the importance of NAD balance for muscle function.

Read the full abstract

All mentions

Reversing Muscle Aging Using Nicotinamide Riboside in Vivo

This study explores how a form of vitamin B3, nicotinamide riboside, can reverse muscle degeneration associated with aging by restoring NAD levels. Findings show potential for treating muscle degeneration and muscular…

VHFILM · Sep 1, 2016 11,561 views

Top Natural Substances for Muscle Building and Regeneration 2018

Review of research on five natural substances from 2015-2017 with potential to reverse muscle loss, including Vitamin E, Nicotinamide Riboside, Leucine, Vitamin D3, and Ursolic Acid, highlighting their roles in muscle…

VHFILM · Jan 18, 2018 1,419 views

Simon Manning

@_Simon_K · X

RT @CharlesMBrenner: NR functioning in skeletal muscle with NAMPT knocked out https://t.co/914HZHBmlp

May 11, 2024 · 1 share · 1,800 followers View post →

Charles Brenner, PhD

@CharlesMBrenner · X

NR functioning in skeletal muscle with NAMPT knocked out https://t.co/914HZHBmlp

May 11, 2024 · 3 likes · 1 share · 57,173 followers View post →

Mike Lustgarten, PhD

@mike_lustgarten · X

Loss of NAD Homeostasis Leads to Progressive and Reversible Degeneration of Skeletal Muscle https://t.co/Ncm1HCVcgJ

Apr 24, 2024 · 1 like · 9,733 followers View post →

Mitominder

@Mitominder · X

Loss of NAD Homeostasis Leads to Progressive and Reversible Degeneration of Skeletal Muscle https://t.co/iiCw4YYa2x

Nov 9, 2020 · 2 likes · 2,258 followers View post →