Publications by authors named "Kaspar P Locher"

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Doxorubicin Recognition and Transport by the MATE Multidrug Transporter NorM From Vibrio cholerae.
Pei-Yu Hsieh, Ksenija Romane, Julia Kowal, Kaspar P Locher, Hendrik W van Veen

J Mol Biol· January 2026

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Corrigendum to "Structural Basis of Drug Recognition by the Multidrug Transporter ABCG2". [J. Mol. Biol. 433 (2021) 166980].
Julia Kowal, Dongchun Ni, Scott M Jackson, Ioannis Manolaridis, Henning Stahlberg, Kaspar P Locher

J Mol Biol· December 2025

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GLYCO-BUILD: an enzymatic pipeline for the synthesis of peptides carrying eukaryotic N-glycans.
Lorenzo Rossi, J Andrew N Alexander, Ana S Ramírez, Kaspar P Locher

Nat Commun· November 2025

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Structure of nanobody-inhibited state of human bile salt transporter NTCP.
Daniel Yoon, Kamil Nosol, Ali Rasouli, Rose Bang-Sørensen, Rossitza N Irobalieva, Kaspar P Locher

Structure· October 2025

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Structural basis of drug recognition by human MATE1 transporter.
Ksenija Romane, Giulia Peteani, Somnath Mukherjee, Julia Kowal, Lorenzo Rossi, Kaspar P Locher

Nat Commun· October 2025

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Organic anion transporting polypeptides: Pharmacology, toxicology, structure, and transport mechanisms.
Bruno Hagenbuch, Bruno Stieger, Kaspar P Locher

Pharmacol Rev· March 2025

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Modulation of ABCG2 Transporter Activity by Ko143 Derivatives.
Qin Yu, Sepehr Dehghani-Ghahnaviyeh, Ali Rasouli, Anna Sadurni, Julia Kowal, Kaspar P Locher

ACS Chem Biol· November 2024

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Structure of antiviral drug bulevirtide bound to hepatitis B and D virus receptor protein NTCP.
Hongtao Liu, Dariusz Zakrzewicz, Kamil Nosol, Rossitza N Irobalieva, Somnath Mukherjee, Kaspar P Locher

Nat Commun· March 2024

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Structural and mechanistic studies of the N-glycosylation machinery: from lipid-linked oligosaccharide biosynthesis to glycan transfer.
Ana S Ramírez, Kaspar P Locher

Glycobiology· December 2023

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Structural basis of bile salt extrusion and small-molecule inhibition in human BSEP.
Hongtao Liu, Rossitza N Irobalieva, Julia Kowal, Dongchun Ni, Kamil Nosol, Kaspar P Locher

Nat Commun· November 2023

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Structural Basis of the Allosteric Inhibition of Human ABCG2 by Nanobodies.
Rossitza N Irobalieva, Ioannis Manolaridis, Scott M Jackson, Dongchun Ni, Els Pardon, Kaspar P Locher

J Mol Biol· October 2023

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Structure of human drug transporters OATP1B1 and OATP1B3.
Anca-Denise Ciută, Kamil Nosol, Julia Kowal, Somnath Mukherjee, Ana S Ramírez, Kaspar P Locher

Nat Commun· September 2023

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Structure, sequon recognition and mechanism of tryptophan C-mannosyltransferase.
Joël S Bloch, Alan John, Runyu Mao, Somnath Mukherjee, Jérémy Boilevin, Kaspar P Locher

Nat Chem Biol· May 2023

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Structure and Mechanism of Human ABC Transporters.
Amer Alam, Kaspar P Locher

Annu Rev Biophys· May 2023

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Emerging structural insights into C-type glycosyltransferases.
J Andrew N Alexander, Kaspar P Locher

Curr Opin Struct Biol· April 2023

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Differential dynamics and direct interaction of bound ligands with lipids in multidrug transporter ABCG2.
Ali Rasouli, Qin Yu, Sepehr Dehghani-Ghahnaviyeh, Po-Chao Wen, Julia Kowal, Kaspar P Locher

Proc Natl Acad Sci U S A· January 2023

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Molecular basis for glycan recognition and reaction priming of eukaryotic oligosaccharyltransferase.
Ana S Ramírez, Mario de Capitani, Giorgio Pesciullesi, Julia Kowal, Joël S Bloch, Kaspar P Locher

Nat Commun· November 2022

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Structure of human NTCP reveals the basis of recognition and sodium-driven transport of bile salts into the liver.
Hongtao Liu, Rossitza N Irobalieva, Rose Bang-Sørensen, Kamil Nosol, Somnath Mukherjee, Kaspar P Locher

Cell Res· August 2022

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Production of Human ABC Transporters and Oligosaccharyltransferase Complexes for Structural Studies.
Ana S Ramírez, Kamil Nosol, Kaspar P Locher

Methods Mol Biol· July 2022

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Generation of nanobodies targeting the human, transcobalamin-mediated vitamin B uptake route.
Joël S Bloch, Jeffrey M Sequeira, Ana S Ramírez, Edward V Quadros, Kaspar P Locher

FASEB J· April 2022

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Discovery and Characterization of Potent Dual P-Glycoprotein and CYP3A4 Inhibitors: Design, Synthesis, Cryo-EM Analysis, and Biological Evaluations.
Sameer Urgaonkar, Kamil Nosol, Ahmed M Said, Nader N Nasief, Yahao Bu, Kaspar P Locher

J Med Chem· January 2022

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Functional analysis of Ost3p and Ost6p containing yeast oligosaccharyltransferases.
Julia D Neuhaus, Rebekka Wild, Jillianne Eyring, Rossitza N Irobalieva, Julia Kowal, Kaspar P Locher

Glycobiology· December 2021

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Development of a universal nanobody-binding Fab module for fiducial-assisted cryo-EM studies of membrane proteins.
Joël S Bloch, Somnath Mukherjee, Julia Kowal, Ekaterina V Filippova, Martina Niederer, Kaspar P Locher

Proc Natl Acad Sci U S A· November 2021

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Structure of the Human Cholesterol Transporter ABCG1.
Liga Skarda, Julia Kowal, Kaspar P Locher

J Mol Biol· October 2021

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