Publications by authors named "Katherine Singleton"

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Haploinsufficiency of GRHL2 is associated with orofacial clefting in humans.
Sarah W Curtis, Cinderella Yang, Alba Sanchis-Juan, Katherine Singleton, Terri H Beaty

Hum Mol Genet· December 2025

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KLK15 alters connective tissues in hypermobile Ehlers-Danlos syndrome.
Cortney Gensemer, Taylor Petrucci, Tyler Beck, Victoria Daylor, Molly Griggs, Katherine Singleton

iScience· September 2025

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Variants in the Kallikrein Gene Family and Hypermobile Ehlers-Danlos Syndrome.
Cortney Gensemer, Tyler Beck, Lilong Guo, Taylor Petrucci, Jordan Morningstar, Katherine Singleton

Res Sq· June 2024

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Drug dependence in cancer is exploitable by optimally constructed treatment holidays.
Jeff Maltas, Shane T Killarney, Katherine R Singleton, Maximilian A R Strobl, Rachel Washart

Nat Ecol Evol· January 2024

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Author Correction: Drug dependence in cancer is exploitable by optimally constructed treatment holidays.
Jeff Maltas, Shane T Killarney, Katherine R Singleton, Maximilian A R Strobl, Rachel Washart

Nat Ecol Evol· January 2024

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MCB-613 exploits a collateral sensitivity in drug resistant -mutant non-small cell lung cancer through covalent inhibition of KEAP1.
Christopher F Bassil, Gray R Anderson, Benjamin Mayro, Kayleigh N Askin, Peter S Winter, Katherine R Singleton

bioRxiv· January 2023

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Using antagonistic pleiotropy to design a chemotherapy-induced evolutionary trap to target drug resistance in cancer.
Kevin H Lin, Justine C Rutter, Abigail Xie, Bryann Pardieu, Emily T Winn, Katherine R Singleton

Nat Genet· April 2020

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Evolved resistance to partial GAPDH inhibition results in loss of the Warburg effect and in a different state of glycolysis.
Maria V Liberti, Annamarie E Allen, Vijyendra Ramesh, Ziwei Dai, Katherine R Singleton

J Biol Chem· January 2020

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Functional RNAi Screens Define Distinct Protein Kinase Vulnerabilities in EGFR-Dependent HNSCC Cell Lines.
Trista K Hinz, Emily K Kleczko, Katherine R Singleton, Jacob Calhoun, Lindsay A Marek

Mol Pharmacol· December 2019

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Analysis of Drug Resistance Using Kinome-Wide Functional Screens.
Katherine R Singleton, Keith T Earley, Lynn E Heasley

Methods Mol Biol· April 2018

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ALK is a critical regulator of the MYC-signaling axis in ALK positive lung cancer.
Amanda B Pilling, Jihye Kim, Adriana Estrada-Bernal, Qiong Zhou, Anh T Le, Katherine R Singleton

Oncotarget· February 2018

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Melanoma Therapeutic Strategies that Select against Resistance by Exploiting MYC-Driven Evolutionary Convergence.
Katherine R Singleton, Lorin Crawford, Elizabeth Tsui, Haley E Manchester, Ophelia Maertens

Cell Rep· December 2017

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Narrowing the focus: a toolkit to systematically connect oncogenic signaling pathways with cancer phenotypes.
Katherine R Singleton, Kris C Wood

Genes Cancer· July 2016

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An Inducible TGF-β2-TGFβR Pathway Modulates the Sensitivity of HNSCC Cells to Tyrosine Kinase Inhibitors Targeting Dominant Receptor Tyrosine Kinases.
Emily K Kleczko, Jihye Kim, Stephen B Keysar, Lydia R Heasley, Justin R Eagles, Katherine R Singleton

PLoS One· February 2016

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Kinome RNAi Screens Reveal Synergistic Targeting of MTOR and FGFR1 Pathways for Treatment of Lung Cancer and HNSCC.
Katherine R Singleton, Trista K Hinz, Emily K Kleczko, Lindsay A Marek, Jeff Kwak

Cancer Res· October 2015

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Systematic identification of signaling pathways with potential to confer anticancer drug resistance.
Colin A Martz, Kathleen A Ottina, Katherine R Singleton, Jeff S Jasper, Suzanne E Wardell

Sci Signal· December 2014

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Bioinformatics-driven discovery of rational combination for overcoming EGFR-mutant lung cancer resistance to EGFR therapy.
Jihye Kim, Vihas T Vasu, Rangnath Mishra, Katherine R Singleton, Minjae Yoo

Bioinformatics· September 2014

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A receptor tyrosine kinase network composed of fibroblast growth factor receptors, epidermal growth factor receptor, v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, and hepatocyte growth factor receptor drives growth and survival of head and neck squamous carcinoma cell lines.
Katherine R Singleton, Jihye Kim, Trista K Hinz, Lindsay A Marek, Matias Casás-Selves

Mol Pharmacol· April 2013

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Fibroblast growth factor receptors are components of autocrine signaling networks in head and neck squamous cell carcinoma cells.
Marianne E Marshall, Trista K Hinz, Scott A Kono, Katherine R Singleton, Brady Bichon

Clin Cancer Res· August 2011

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Elevated extracellular K+ inhibits apoptosis of corneal epithelial cells exposed to UV-B radiation.
Katherine R Singleton, David S Will, Mark P Schotanus, Loren D Haarsma, Leah R Koetje

Exp Eye Res· August 2009

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