Publications by authors named "Kathy Keith"

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Synthesis of novel 6-azacytidine prodrugs as potent influenza A inhibitors.
Omar Moukha-Chafiq, Larry D Bratton, Shuklendu D Karyakarte, Kathy Keith, Yohanka Martinez-Gzegozewska

Bioorg Med Chem Lett· February 2026

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Exploring Phosphate Substitution in Heparan Sulfate Mimetics: Synthesis and Antiviral Evaluation.
Arran W Stewart, Andrew J Marshall, Sam Spijkers-Shaw, Kathy A Keith, Scott H James

ChemMedChem· November 2025

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In Silico Design and Experimental Validation of Novel Oxazole Derivatives Against Varicella zoster virus.
Vasyl Kovalishyn, Oleksandr Severin, Maryna Kachaeva, Oleksandr Kobzar, Kathy A Keith

Mol Biotechnol· April 2024

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A ProTide of AZT Shows Activity Against Human Papillomaviruses.
Tim Gniech, Adrian Humboldt, Kathy A Keith, Scott H James, Clemens Richert

ChemMedChem· April 2024

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NPP-669, a Novel Broad-Spectrum Antiviral Therapeutic with Excellent Cellular Uptake, Antiviral Potency, Oral Bioavailability, Preclinical Efficacy, and a Promising Safety Margin.
Elke Lipka, Aaron M Chadderdon, Cheryl C Harteg, Matthew K Doherty, Eric S Simon, Kathy A Keith

Mol Pharm· January 2023

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Design of new imidazole derivatives with anti-HCMV activity: QSAR modeling, synthesis and biological testing.
Vasyl Kovalishyn, Volodymyr Zyabrev, Maryna Kachaeva, Kostiantyn Ziabrev, Kathy Keith

J Comput Aided Mol Des· December 2021

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A standardized approach to the evaluation of antivirals against DNA viruses: Orthopox-, adeno-, and herpesviruses.
Caroll B Hartline, Kathy A Keith, Jessica Eagar, Emma A Harden, Terry L Bowlin

Antiviral Res· November 2018

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A standardized approach to the evaluation of antivirals against DNA viruses: Polyomaviruses and lymphotropic herpesviruses.
Kathy A Keith, Caroll B Hartline, Terry L Bowlin, Mark N Prichard

Antiviral Res· November 2018

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Synthesis and Antiviral Evaluation of Octadecyloxyethyl Benzyl 9-[(2-Phosphonomethoxy)ethyl]guanine (ODE-Bn-PMEG), a Potent Inhibitor of Transient HPV DNA Amplification.
James R Beadle, Nadejda Valiaeva, Guang Yang, Jei-Hwa Yu, Thomas R Broker, Kathy A Keith

J Med Chem· December 2016

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New small molecule entry inhibitors targeting hemagglutinin-mediated influenza a virus fusion.
Arnab Basu, Aleksandar Antanasijevic, Minxiu Wang, Bing Li, Debra M Mills, Kathy A Keith

J Virol· February 2014

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Synthesis and antiviral activity of certain second generation methylenecyclopropane nucleosides.
John D Williams, Atiyya R Khan, Emma A Harden, Caroll B Hartline, Geraldine M Jefferson, Kathy A Keith

Bioorg Med Chem· June 2012

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Identification of protein-protein interaction inhibitors targeting vaccinia virus processivity factor for development of antiviral agents.
Norbert Schormann, Charnell Inglis Sommers, Mark N Prichard, Kathy A Keith, James W Noah

Antimicrob Agents Chemother· November 2011

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Synthesis, metabolic stability and antiviral evaluation of various alkoxyalkyl esters of cidofovir and 9-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]adenine.
Jacqueline Ruiz, James R Beadle, R Mark Buller, Jill Schreiwer, Mark N Prichard, Kathy A Keith

Bioorg Med Chem· May 2011

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Antiviral evaluation of octadecyloxyethyl esters of (S)-3-hydroxy-2-(phosphonomethoxy)propyl nucleosides against herpesviruses and orthopoxviruses.
Nadejda Valiaeva, Mark N Prichard, R Mark Buller, James R Beadle, Caroll B Hartline, Kathy A Keith

Antiviral Res· December 2009

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Activities of certain 5-substituted 4'-thiopyrimidine nucleosides against orthopoxvirus infections.
Earl R Kern, Mark N Prichard, Debra C Quenelle, Kathy A Keith, Kamal N Tiwari

Antimicrob Agents Chemother· February 2009

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Isolation and characterization of cidofovir resistant vaccinia viruses.
Marie N Becker, Maria Obraztsova, Earl R Kern, Debra C Quenelle, Kathy A Keith

Virol J· May 2008

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Vaccinia virus lacking the deoxyuridine triphosphatase gene (F2L) replicates well in vitro and in vivo, but is hypersensitive to the antiviral drug (N)-methanocarbathymidine.
Mark N Prichard, Earl R Kern, Debra C Quenelle, Kathy A Keith, Richard W Moyer

Virol J· March 2008

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Synergistic efficacy of the combination of ST-246 with CMX001 against orthopoxviruses.
Debra C Quenelle, Mark N Prichard, Kathy A Keith, Dennis E Hruby, Robert Jordan

Antimicrob Agents Chemother· November 2007

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Effect of oral treatment with hexadecyloxypropyl-[(S)-9-(3-hydroxy-2- phosphonylmethoxypropyl)adenine] [(S)-HPMPA] or octadecyloxyethyl-(S)-HPMPA on cowpox or vaccinia virus infections in mice.
Debra C Quenelle, Deborah J Collins, Bridgett P Herrod, Kathy A Keith, Julissa Trahan

Antimicrob Agents Chemother· November 2007

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Synthesis and antiviral evaluation of alkoxyalkyl-phosphate conjugates of cidofovir and adefovir.
Jacqueline C Ruiz, James R Beadle, Kathy A Aldern, Kathy A Keith, Caroll B Hartline

Antiviral Res· July 2007

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Selective phosphorylation of antiviral drugs by vaccinia virus thymidine kinase.
Mark N Prichard, Kathy A Keith, Mary P Johnson, Emma A Harden, Alexis McBrayer

Antimicrob Agents Chemother· May 2007

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N-(3,3a,4,4a,5,5a,6,6a-Octahydro-1,3-dioxo-4,6- ethenocycloprop[f]isoindol-2-(1H)-yl)carboxamides: Identification of novel orthopoxvirus egress inhibitors.
Thomas R Bailey, Susan R Rippin, Elizabeth Opsitnick, Christopher J Burns, Daniel C Pevear, Kathy A Keith

J Med Chem· April 2007

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Efficacy of delayed treatment with ST-246 given orally against systemic orthopoxvirus infections in mice.
Debra C Quenelle, R M L Buller, Scott Parker, Kathy A Keith, Dennis E Hruby

Antimicrob Agents Chemother· February 2007

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Antiviral activities of novel 5-phosphono-pent-2-en-1-yl nucleosides and their alkoxyalkyl phosphonoesters.
Hyunah Choo, James R Beadle, Earl R Kern, Mark N Prichard, Kathy A Keith

Antimicrob Agents Chemother· February 2007

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Short communication inhibitory activity of 4-[(1,2-dihydro-2-oxo-3H-indol-3-ylidene)amino]-N-(4,6-dimethylpyrimidin-2-yl) benzenesulphonamide and its derivatives against orthopoxvirus replication in vitro.
Periyasamy Selvam, Narayanan Murugesh, Markandavel Chandramohan, Kathy A Keith, Earl R Kern

Antivir Chem Chemother· November 2006

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