Publications by authors named "Kay Grobe"

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Evolution of SARS-CoV-2 spike trimers towards optimized heparan sulfate cross-linking and inter-chain mobility.
Jurij Froese, Marco Mandalari, Monica Civera, Stefano Elli, Isabel Pagani, Kay Grobe

Sci Rep· December 2024

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Two-way Dispatched function in Sonic hedgehog shedding and transfer to high-density lipoproteins.
Kristina Ehring, Sophia Friederike Ehlers, Jurij Froese, Fabian Gude, Janna Puschmann, Kay Grobe

Elife· September 2024

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A Residual N-Terminal Peptide Enhances Signaling of Depalmitoylated Hedgehog to the Patched Receptor.
Sophia F Ehlers, Dominique Manikowski, Georg Steffes, Kristina Ehring, Fabian Gude, Kay Grobe

J Dev Biol· April 2024

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Editorial: Heparan sulfate-binding proteins in health and disease.
Lauren A Gandy, Fuming Zhang, Ding Xu, Lars C Pedersen, Kay Grobe

Front Mol Biosci· March 2024

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Hedgehog on the Move: Glypican-Regulated Transport and Gradient Formation in .
Carlos Jiménez-Jiménez, Kay Grobe, Isabel Guerrero

Cells· February 2024

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The role of glycosaminoglycan modification in Hedgehog regulated tissue morphogenesis.
Fabian Gude, Jurij Froese, Georg Steffes, Kay Grobe

Biochem Soc Trans· June 2023

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Hedgehog is relayed through dynamic heparan sulfate interactions to shape its gradient.
Fabian Gude, Jurij Froese, Dominique Manikowski, Daniele Di Iorio, Jean-Noël Grad, Kay Grobe

Nat Commun· February 2023

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hedgehog signaling range and robustness depend on direct and sustained heparan sulfate interactions.
Dominique Manikowski, Georg Steffes, Jurij Froese, Sebastian Exner, Kristina Ehring, Kay Grobe

Front Mol Biosci· February 2023

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Targeting of bone morphogenetic protein complexes to heparin/heparan sulfate glycosaminoglycans in bioactive conformation.
Chara E S Spanou, Alexander P Wohl, Sandra Doherr, Annkatrin Correns, Niklas Sonntag, Kay Grobe

FASEB J· January 2023

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Conserved cholesterol-related activities of Dispatched 1 drive Sonic hedgehog shedding from the cell membrane.
Kristina Ehring, Dominique Manikowski, Jonas Goretzko, Jurij Froese, Fabian Gude, Kay Grobe

J Cell Sci· March 2022

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Dispatching plasma membrane cholesterol and Sonic Hedgehog dispatch: two sides of the same coin?
Kristina Ehring, Kay Grobe

Biochem Soc Trans· November 2021

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Hedgehog lipids: Promotors of alternative morphogen release and signaling?: Conflicting findings on lipidated Hedgehog transport and signaling can be explained by alternative regulated mechanisms to release the morphogen.
Dominique Manikowski, Kristina Ehring, Fabian Gude, Petra Jakobs, Jurij Froese, Kay Grobe

Bioessays· November 2021

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Surface expression of the immunotherapeutic target G in osteosarcoma depends on cell confluency.
Malena Wiebel, Sareetha Kailayangiri, Bianca Altvater, Jutta Meltzer, Kay Grobe

Cancer Rep (Hoboken)· October 2021

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C-Terminal Peptide Modifications Reveal Direct and Indirect Roles of Hedgehog Morphogen Cholesteroylation.
Dominique Manikowski, Philipp Kastl, Sabine Schürmann, Kristina Ehring, Georg Steffes, Kay Grobe

Front Cell Dev Biol· January 2021

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Dally-like Is Unlike Dally in Assisting Wingless Spread.
Kay Grobe, Isabel Guerrero

Dev Cell· September 2020

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Cerebellar Morphology and Behavioral Profiles in Mice Lacking Heparan Sulfate Gene Function.
Lars Lewejohann, Srinivas R Pallerla, Rebecca S Schreiber, Joanna Gerula, Kay Grobe

J Dev Biol· July 2020

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Mature oligodendrocytes bordering lesions limit demyelination and favor myelin repair via heparan sulfate production.
Magali Macchi, Karine Magalon, Céline Zimmer, Elitsa Peeva, Bilal El Waly, Kay Grobe

Elife· June 2020

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Neutralising anti-drug antibodies in Fabry disease can inhibit endothelial enzyme uptake and activity.
Franciska Stappers, David Scharnetzki, Boris Schmitz, Dominique Manikowski, Stefan-Martin Brand, Kay Grobe

J Inherit Metab Dis· March 2020

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Soluble Heparin and Heparan Sulfate Glycosaminoglycans Interfere with Sonic Hedgehog Solubilization and Receptor Binding.
Dominique Manikowski, Petra Jakobs, Hamodah Jboor, Kay Grobe

Molecules· April 2019

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Secreted metalloproteases ADAMTS9 and ADAMTS20 have a non-canonical role in ciliary vesicle growth during ciliogenesis.
Sumeda Nandadasa, Caroline M Kraft, Lauren W Wang, Anna O'Donnell, Rushabh Patel, Kay Grobe

Nat Commun· February 2019

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Disrupting Hedgehog Cardin-Weintraub sequence and positioning changes cellular differentiation and compartmentalization .
Philipp Kastl, Dominique Manikowski, Georg Steffes, Sabine Schürmann, Shyam Bandari, Kay Grobe

Development· September 2018

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Proteolytic processing of palmitoylated Hedgehog peptides specifies the 3-4 intervein region of the wing.
Sabine Schürmann, Georg Steffes, Dominique Manikowski, Philipp Kastl, Ursula Malkus, Kay Grobe

Elife· March 2018

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Taking the Occam's Razor Approach to Hedgehog Lipidation and Its Role in Development.
Dominique Manikowski, Philipp Kastl, Kay Grobe

J Dev Biol· January 2018

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Ca coordination controls sonic hedgehog structure and its Scube2-regulated release.
Petra Jakobs, Philipp Schulz, Sabine Schürmann, Stephan Niland, Sebastian Exner, Kay Grobe

J Cell Sci· October 2017

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Sonic hedgehog processing and release are regulated by glypican heparan sulfate proteoglycans.
Corinna Ortmann, Ute Pickhinke, Sebastian Exner, Stefanie Ohlig, Roger Lawrence, Kay Grobe

J Cell Sci· December 2015

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