Publications by authors named "Kaylen R Meeks"

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Biochemical, structural, and cellular characterization of S-but-3-yn-2-ylglycine as a mechanism-based covalent inactivator of the flavoenzyme proline dehydrogenase.
Kaylen R Meeks, Juan Ji, Gary K Scott, Ashley C Campbell, Jay C Nix

Arch Biochem Biophys· March 2025

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Crystallographic Fragment Screening of a Bifunctional Proline Catabolic Enzyme Reveals New Inhibitor Templates for Proline Dehydrogenase and L-Glutamate-γ-semialdehyde Dehydrogenase.
Kaylen R Meeks, Alexandra N Bogner, Jay C Nix, John J Tanner

Molecules· November 2024

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Screening a knowledge-based library of low molecular weight compounds against the proline biosynthetic enzyme 1-pyrroline-5-carboxylate 1 (PYCR1).
Kaylen R Meeks, Alexandra N Bogner, John J Tanner

Protein Sci· July 2024

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Novel Fragment Inhibitors of PYCR1 from Docking-Guided X-ray Crystallography.
Kaylen R Meeks, Juan Ji, Mykola V Protopopov, Olga O Tarkhanova, Yurii S Moroz

J Chem Inf Model· March 2024

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Expression and kinetic characterization of PYCR3.
Kaylen R Meeks, John J Tanner

Arch Biochem Biophys· January 2023

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Functional Impact of a Cancer-Related Variant in Human Δ-Pyrroline-5-Carboxylate Reductase 1.
Oseeyi I Daudu, Kaylen R Meeks, Lu Zhang, Javier Seravalli, John J Tanner

ACS Omega· January 2023

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