Publications by authors named "Kedan Lin"

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Phase Ia Study of Anti-NaPi2b Antibody-Drug Conjugate Lifastuzumab Vedotin DNIB0600A in Patients with Non-Small Cell Lung Cancer and Platinum-Resistant Ovarian Cancer.
David E Gerber, Jeffrey R Infante, Michael S Gordon, Sarah B Goldberg, Miguel Martín, Kedan Lin

Clin Cancer Res· January 2020

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Biodistribution and efficacy of an anti-TENB2 antibody-drug conjugate in a patient-derived model of prostate cancer.
C Andrew Boswell, Daniela Bumbaca Yadav, Eduardo E Mundo, Shang-Fan Yu, Jennifer Arca Lacap, Kedan Lin

Oncotarget· October 2019

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Single cell-produced and in vitro-assembled anti-FcRH5/CD3 T-cell dependent bispecific antibodies have similar in vitro and in vivo properties.
Ayse Meric Ovacik, Ji Li, Marie Lemper, Dimitry Danilenko, Nicola Stagg, Kedan Lin

MAbs· July 2019

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Tutorial on Monoclonal Antibody Pharmacokinetics and Its Considerations in Early Development.
Meric Ovacik, Kedan Lin

Clin Transl Sci· November 2018

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Relative Target Affinities of T-Cell-Dependent Bispecific Antibodies Determine Biodistribution in a Solid Tumor Mouse Model.
Danielle Mandikian, Nene Takahashi, Amy A Lo, Ji Li, Jeffrey Eastham-Anderson, Kedan Lin

Mol Cancer Ther· April 2018

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Efficient production of bispecific IgG of different isotypes and species of origin in single mammalian cells.
Michael Dillon, Yiyuan Yin, Jianhui Zhou, Luke McCarty, Diego Ellerman, Kedan Lin

MAbs· November 2017

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An anti-CD3/anti-CLL-1 bispecific antibody for the treatment of acute myeloid leukemia.
Steven R Leong, Siddharth Sukumaran, Maria Hristopoulos, Klara Totpal, Shannon Stainton, Kedan Lin

Blood· February 2017

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Development and Translational Application of an Integrated, Mechanistic Model of Antibody-Drug Conjugate Pharmacokinetics.
Siddharth Sukumaran, Crystal Zhang, Douglas D Leipold, Ola M Saad, Keyang Xu, Kedan Lin

AAPS J· January 2017

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Preclinical Development of an Anti-NaPi2b (SLC34A2) Antibody-Drug Conjugate as a Therapeutic for Non-Small Cell Lung and Ovarian Cancers.
Kedan Lin, Bonnee Rubinfeld, Crystal Zhang, Ron Firestein, Eric Harstad

Clin Cancer Res· November 2015

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Mechanism-Based Pharmacokinetic/Pharmacodynamic Model for THIOMAB™ Drug Conjugates.
Siddharth Sukumaran, Kapil Gadkar, Crystal Zhang, Sunil Bhakta, Luna Liu, Kedan Lin

Pharm Res· June 2015

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Pharmacokinetics and ADME characterizations of antibody-drug conjugates.
Kedan Lin, Jay Tibbitts, Ben-Quan Shen

Methods Mol Biol· February 2014

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Fourth World Antibody-Drug Conjugate Summit: February 29-March 1, 2012, Frankfurt, Germany.
Alain Beck, John Lambert, Michael Sun, Kedan Lin

MAbs· January 2014

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Conjugates of Small Molecule Drugs with Antibodies and Other Proteins.
Yang Feng, Zhongyu Zhu, Weizao Chen, Ponraj Prabakaran, Kedan Lin

Biomedicines· January 2014

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Total antibody quantification for MMAE-conjugated antibody-drug conjugates: impact of assay format and reagents.
Katherine R Kozak, Siao Ping Tsai, Aimee Fourie-O'Donohue, Josefa dela Cruz Chuh, Leslie Roth, Kedan Lin

Bioconjug Chem· May 2013

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Characterization of the drug-to-antibody ratio distribution for antibody-drug conjugates in plasma/serum.
Keyang Xu, Luna Liu, Randall Dere, Elaine Mai, Rebecca Erickson, Kedan Lin

Bioanalysis· May 2013

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Micro-volume wall-less immunoassays using patterned planar plates.
Katherine R Kozak, Jianyong Wang, Melvin Lye, Josefa dela Cruz Chuh, Rashi Takkar, Kedan Lin

Lab Chip· April 2013

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An integrated approach to identify normal tissue expression of targets for antibody-drug conjugates: case study of TENB2.
C Andrew Boswell, Eduardo E Mundo, Ron Firestein, Crystal Zhang, Weiguang Mao, Kedan Lin

Br J Pharmacol· January 2013

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Pharmacokinetic considerations for antibody drug conjugates.
Kedan Lin, Jay Tibbitts

Pharm Res· September 2012

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Differential effects of predosing on tumor and tissue uptake of an 111In-labeled anti-TENB2 antibody-drug conjugate.
C Andrew Boswell, Eduardo E Mundo, Crystal Zhang, Shannon L Stainton, Shang-Fan Yu, Kedan Lin

J Nucl Med· September 2012

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Impact of drug conjugation on pharmacokinetics and tissue distribution of anti-STEAP1 antibody-drug conjugates in rats.
C Andrew Boswell, Eduardo E Mundo, Crystal Zhang, Daniela Bumbaca, Nicole R Valle, Kedan Lin

Bioconjug Chem· October 2011

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Serum response factor activation by muscarinic receptors via RhoA. Novel pathway specific to M1 subtype involving calmodulin, calcineurin, and Pyk2.
Kedan Lin, Danxin Wang, Wolfgang Sadée

J Biol Chem· October 2002

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