Publications by authors named "Kees Smid"

Claim this Profile
T
The role of l-leucovorin uptake and metabolism in the modulation of 5-fluorouracil efficacy and antifolate toxicity.
Godefridus J Peters, Ietje Kathmann, Elisa Giovannetti, Kees Smid, Yehuda G Assaraf

Front Pharmacol· August 2024

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
I
Impact of hypoxia on chemoresistance of mesothelioma mediated by the proton-coupled folate transporter, and preclinical activity of new anti-LDH-A compounds.
Giovanna Li Petri, Btissame El Hassouni, Rocco Sciarrillo, Niccola Funel, Giulia Mantini, Kees Smid

Br J Cancer· August 2020

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
T
Thiopurines with low-dose allopurinol (ThiLDA)-a prospective clinical one-way crossover trial.
S Faraz Chavoushi, Bindia Jharap, Philip Friedrich, Kees Smid, Godefridus J Peters

Eur J Clin Pharmacol· December 2019

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
T
The Cytidine Analog Fluorocyclopentenylcytosine (RX-3117) Is Activated by Uridine-Cytidine Kinase 2.
Dzjemma Sarkisjan, Joris R Julsing, Kees Smid, Daniël de Klerk, André B P van Kuilenburg

PLoS One· August 2017

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
I
Inhibition of thymidylate synthase by 2',2'-difluoro-2'-deoxycytidine (Gemcitabine) and its metabolite 2',2'-difluoro-2'-deoxyuridine.
Richard J Honeywell, Veronique W T Ruiz van Haperen, Gijsbert Veerman, Kees Smid, Godefridus J Peters

Int J Biochem Cell Biol· March 2015

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
O
Overexpression of MRP4 (ABCC4) and MRP5 (ABCC5) confer resistance to the nucleoside analogs cytarabine and troxacitabine, but not gemcitabine.
Auke D Adema, Karijn Floor, Kees Smid, Richard J Honeywell, George L Scheffer

Springerplus· February 2015

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
A
A novel cytidine analog, RX-3117, shows potent efficacy in xenograft models, even in tumors that are resistant to gemcitabine.
Mi Young Yang, Young Bok Lee, Chang-Ho Ahn, Joel Kaye, Tania Fine, Kees Smid

Anticancer Res· December 2014

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
M
Metabolism, mechanism of action and sensitivity profile of fluorocyclopentenylcytosine (RX-3117; TV-1360).
Godefridus J Peters, Kees Smid, Leonardo Vecchi, Ietje Kathmann, Dzjemma Sarkisjan

Invest New Drugs· December 2013

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
M
Metabolism and accumulation of the lipophilic deoxynucleoside analogs elacytarabine and CP-4126.
Auke D Adema, Kees Smid, Nienke Losekoot, Richard J Honeywell, Henk M Verheul

Invest New Drugs· October 2012

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
D
DNA copy number profiles correlate with outcome in colorectal cancer patients treated with fluoropyrimidine/antifolate-based regimens.
Leticia G Leon, Elisa Giovannetti, Kees Smid, Bart P P van Houte, Axel R Hanauske

Curr Drug Metab· December 2011

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
A
Allopurinol enhances the activity of hypoxanthine-guanine phosphoribosyltransferase in inflammatory bowel disease patients during low-dose thiopurine therapy: preliminary data of an ongoing series.
Margien L Seinen, Nanne K H de Boer, Kees Smid, Dirk P van Asseldonk, Gerd Bouma

Nucleosides Nucleotides Nucleic Acids· December 2011

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
C
Cellular pharmacology of multi- and duplex drugs consisting of ethynylcytidine and 5-fluoro-2'-deoxyuridine.
Irene V Bijnsdorp, Reto A Schwendener, Herbert Schott, Iduna Fichtner, Kees Smid

Invest New Drugs· April 2011

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
T
Trifluorothymidine resistance is associated with decreased thymidine kinase and equilibrative nucleoside transporter expression or increased secretory phospholipase A2.
Olaf H Temmink, Irene V Bijnsdorp, Henk-Jan Prins, Nienke Losekoot, Auke D Adema, Kees Smid

Mol Cancer Ther· April 2010

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
M
Molecular mechanism underlying the synergistic interaction between trifluorothymidine and the epidermal growth factor receptor inhibitor erlotinib in human colorectal cancer cell lines.
Irene V Bijnsdorp, Frank A E Kruyt, Masakazu Fukushima, Kees Smid, Shanti Gokoel

Cancer Sci· February 2010

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
P
Polymorphisms in the enhancer region of the thymidylate synthase gene are associated with thymidylate synthase levels in normal tissues but not in malignant tissues of patients with colorectal cancer.
Robert Mauritz, Elisa Giovannetti, Ines J Beumer, Kees Smid, Cees J Van Groeningen

Clin Colorectal Cancer· July 2009

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
M
Molecular mechanisms underlying the synergistic interaction of erlotinib, an epidermal growth factor receptor tyrosine kinase inhibitor, with the multitargeted antifolate pemetrexed in non-small-cell lung cancer cells.
Elisa Giovannetti, Clara Lemos, Christina Tekle, Kees Smid, Sara Nannizzi

Mol Pharmacol· April 2008

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
I
In vivo and in vitro activity and mechanism of action of the multidrug cytarabine-L-glycerylyl-fluorodeoxyuridine.
Irene V Bijnsdorp, Reto A Schwendener, Herbert Schott, Iduna Fichtner, Kees Smid

Nucleosides Nucleotides Nucleic Acids· March 2008

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
T
Thymidylate synthase and dihydropyrimidine dehydrogenase mRNA expression after administration of 5-fluorouracil to patients with colorectal cancer.
Robert Mauritz, Cees J van Groeningen, Kees Smid, Gerrit Jansen, Herbert M Pinedo

Int J Cancer· June 2007

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
E
Effects of gemcitabine on cis-platinum-DNA adduct formation and repair in a panel of gemcitabine and cisplatin-sensitive or -resistant human ovarian cancer cell lines.
Godefridus J Peters, Catharina J A Van Moorsel, Bianca Lakerveld, Kees Smid, Paul Noordhuis

Int J Oncol· January 2006

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
E
Expression microarray analysis and oligo array comparative genomic hybridization of acquired gemcitabine resistance in mouse colon reveals selection for chromosomal aberrations.
Mark A van de Wiel, Jose L Costa, Kees Smid, Cees B M Oudejans, Andries M Bergman

Cancer Res· November 2005

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
I
In vivo induction of resistance to gemcitabine results in increased expression of ribonucleotide reductase subunit M1 as the major determinant.
Andries M Bergman, Paul P Eijk, Veronique W T Ruiz van Haperen, Kees Smid, Gijsbert Veerman

Cancer Res· October 2005

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
T
The effect of fluoropyrimidines with or without thymidine phosphorylase inhibitor on the expression of thymidine phosphorylase.
Michiel De Bruin, Toni Van Capel, Kees Smid, Masakazu Fukushima, Klaas Hoekman

Eur J Pharmacol· May 2004

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
H
High-dose 5-Fluorouracil with uridine-diphosphoglucose rescue increases thymidylate synthase inhibition but not 5-Fluorouracil incorporation into RNA in murine tumors.
Giovanni Codacci-Pisanelli, Clasina L Van der Wilt, Kees Smid, Paul Noordhuis, Daphne Voorn

Oncology· August 2002

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
E
Effects of antifolates on the binding of 5-fluoro-2'-deoxyuridine monophosphate to thymidylate synthase.
Clasina L van der Wilt, Kees Smid, Godefridus J Peters

Biochem Pharmacol· August 2002

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis