Publications by authors named "Keiichi Higuchi"

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Effects of lifetime supplementation with ubiquinol 10 on the lifespan and progression of aging in female C57BL/6 mice.
Yuichi Igarashi, Sakiko Hamada, Jin Dai, Masayuki Mori, Hiroki Miyahara, Keiichi Higuchi

Exp Gerontol· November 2025

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Classification of amyloidosis and protein misfolding disorders in animals 2024: A review on pathology and diagnosis.
Susumu Iwaide, Tomoaki Murakami, Niki Sedghi Masoud, Natsumi Kobayashi, Jessica S Fortin, Keiichi Higuchi

Vet Pathol· March 2025

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Insights into the Structural Basis of Amyloid Resistance Provided by Cryo-EM Structures of AApoAII Amyloid Fibrils.
Giada Andreotti, Julian Baur, Marijana Ugrina, Peter Benedikt Pfeiffer, Max Hartmann, Keiichi Higuchi

J Mol Biol· February 2024

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Macrophages in the reticuloendothelial system inhibit early induction stages of mouse apolipoprotein A-II amyloidosis.
Hiroki Miyahara, Jian Dai, Ying Li, Xiaoran Cui, Hibiki Takeuchi, Keiichi Higuchi

Amyloid· June 2023

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Renal Function in Aged C57BL/6J Mice Is Impaired by Deposition of Age-Related Apolipoprotein A-II Amyloid Independent of Kidney Aging.
Ying Li, Jian Dai, Fuyuki Kametani, Masahide Yazaki, Akihito Ishigami, Keiichi Higuchi

Am J Pathol· June 2023

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BALB.NCT- is a unique mouse model of hereditary coproporphyria.
Xiaojing Kang, Shin Shimada, Hiroki Miyahara, Keiichi Higuchi, Masayuki Mori

Mol Genet Metab Rep· June 2023

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Cyba and Nox2 mutant rats show different incidences of eosinophilia in the genetic background- and sex-dependent manner.
Masayuki Mori, Jian Dai, Hiroki Miyahara, Ying Li, Xiaojing Kang, Keiichi Higuchi

Exp Anim· May 2023

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Neural oscillations accompanying 14-Hz positive spikes: A case report.
Eishi Motomura, Koji Inui, Yusuke Nakayama, Keiichi Higuchi, Tomosuke Nakano

Neurophysiol Clin· February 2023

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Polygenic control of the wavy coat of the NCT mouse: involvement of an intracisternal A particle insertional mutation of the protease, serine 53 (Prss53) gene, and a modifier gene.
Masayuki Mori, Chang Liu, Takahiro Yoshizawa, Hiroki Miyahara, Jian Dai, Keiichi Higuchi

Mamm Genome· September 2022

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Exercise suppresses mouse systemic AApoAII amyloidosis through enhancement of the p38 MAPK signaling pathway.
Xiaoran Cui, Jinko Sawashita, Jian Dai, Chang Liu, Yuichi Igarashi, Keiichi Higuchi

Dis Model Mech· March 2022

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Involvement of increased endoplasmic reticulum stress in the development of cataracts in BALB.NCT-Cpox mice.
Chang Liu, Hiroki Miyahara, Jian Dai, Xiaoran Cui, Ying Li, Keiichi Higuchi

Exp Eye Res· February 2022

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Weaker prepulse exerts stronger suppression of a change-detecting neural circuit.
Shinobu Fujii, Eishi Motomura, Koji Inui, Takayasu Watanabe, Yuhei Hakumoto, Keiichi Higuchi

Neurosci Res· September 2021

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Glavonoid-rich oil supplementation reduces stearoyl-coenzyme A desaturase 1 expression and improves systemic metabolism in diabetic, obese KK-A mice.
Yuichi Igarashi, Shiho Iida, Jian Dai, Jia Huo, Xiaoran Cui, Keiichi Higuchi

Biomed Pharmacother· August 2021

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Development of diagnostic antibodies against immunoglobulin heavy chain variable region for heavy chain amyloidosis (AH amyloidosis).
Mayuko Nakagawa, Masahide Yazaki, Fuyuki Kametani, Nagaaki Katoh, Tsuneaki Yoshinaga, Keiichi Higuchi

Pathol Int· April 2021

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Dialysis-related amyloidosis associated with a novel β-microglobulin variant.
Hiroki Mizuno, Junichi Hoshino, Masatomo So, Yuta Kogure, Takeshi Fujii, Keiichi Higuchi

Amyloid· March 2021

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Curcumin promotes AApoAII amyloidosis and peroxisome proliferation in mice by activating the PPARα signaling pathway.
Jian Dai, Ying Li, Fuyuki Kametani, Xiaoran Cui, Yuichi Igarashi, Keiichi Higuchi

Elife· January 2021

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Suppression of Mouse AApoAII Amyloidosis Progression by Daily Supplementation with Oxidative Stress Inhibitors.
Jian Dai, Xin Ding, Hiroki Miyahara, Zhe Xu, Xiaoran Cui, Keiichi Higuchi

Oxid Med Cell Longev· February 2020

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Recognition on trigger condition of autonomous emergency braking system.
Yasuhiro Mimura, Ryosuke Ando, Keiichi Higuchi, Jia Yang

J Safety Res· February 2020

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[The senescence-accelerated mouse as a model for geriatrics and aging biology].
Masayuki Mori, Keiichi Higuchi

Nihon Yakurigaku Zasshi· May 2019

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Coenzyme Q10 Prevents Senescence and Dysfunction Caused by Oxidative Stress in Vascular Endothelial Cells.
Jia Huo, Zhe Xu, Kazunori Hosoe, Hiroshi Kubo, Hiroki Miyahara, Keiichi Higuchi

Oxid Med Cell Longev· December 2018

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Amyloidosis-inducing activity of blood cells in mouse AApoAII amyloidosis.
Xin Ding, Yingye Liu, Mu Yang, Lin Li, Hiroki Miyahara, Keiichi Higuchi

Exp Anim· May 2018

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Apolipoprotein A-II induces acute-phase response associated AA amyloidosis in mice through conformational changes of plasma lipoprotein structure.
Mu Yang, Yingye Liu, Jian Dai, Lin Li, Xin Ding, Keiichi Higuchi

Sci Rep· April 2018

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Comprehensive proteomic profiles of mouse AApoAII amyloid fibrils provide insights into the involvement of lipoproteins in the pathology of amyloidosis.
Hiroki Miyahara, Jinko Sawashita, Eri Ishikawa, Mu Yang, Xin Ding, Keiichi Higuchi

J Proteomics· February 2018

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Coenzyme Q10 Improves Lipid Metabolism and Ameliorates Obesity by Regulating CaMKII-Mediated PDE4 Inhibition.
Zhe Xu, Jia Huo, Xin Ding, Mu Yang, Lin Li, Keiichi Higuchi

Sci Rep· August 2017

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Caloric restriction prevents the progression of murine AApoAII amyloidosis.
Jinko Sawashita, Lin Li, Yingye Liu, Xin Ding, Mu Yang, Keiichi Higuchi

Amyloid· March 2017

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