Publications by authors named "Keith A Hoffmaster"

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Membrane transporters in drug development.

Nat Rev Drug Discov· March 2010

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Apparent differences in mechanisms of harmol sulfate biliary excretion in mice and rats.
Maciej J Zamek-Gliszczynski, Keith A Hoffmaster, Ken-ichi Nezasa, Kim L R Brouwer

Drug Metab Dispos· November 2008

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Differential involvement of Mrp2 (Abcc2) and Bcrp (Abcg2) in biliary excretion of 4-methylumbelliferyl glucuronide and sulfate in the rat.
Maciej J Zamek-Gliszczynski, Keith A Hoffmaster, Joan E Humphreys, Xianbin Tian, Ken-Ichi Nezasa

J Pharmacol Exp Ther· October 2006

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Hepatobiliary disposition of a drug/metabolite pair: Comprehensive pharmacokinetic modeling in sandwich-cultured rat hepatocytes.
Ryan Z Turncliff, Keith A Hoffmaster, J Cory Kalvass, Gary M Pollack, Kim L R Brouwer

J Pharmacol Exp Ther· August 2006

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Integration of hepatic drug transporters and phase II metabolizing enzymes: mechanisms of hepatic excretion of sulfate, glucuronide, and glutathione metabolites.
Maciej J Zamek-Gliszczynski, Keith A Hoffmaster, Ken-ichi Nezasa, Melanie N Tallman, Kim L R Brouwer

Eur J Pharm Sci· April 2006

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Multiple mechanisms are involved in the biliary excretion of acetaminophen sulfate in the rat: role of Mrp2 and Bcrp1.
Maciej J Zamek-Gliszczynski, Keith A Hoffmaster, Xianbin Tian, Rong Zhao, Joseph W Polli

Drug Metab Dispos· August 2005

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Multiple transport systems mediate the hepatic uptake and biliary excretion of the metabolically stable opioid peptide [D-penicillamine2,5]enkephalin.
Keith A Hoffmaster, Maciej J Zamek-Gliszczynski, Gary M Pollack, Kim L R Brouwer

Drug Metab Dispos· February 2005

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Hepatobiliary disposition of the metabolically stable opioid peptide [D-Pen2, D-Pen5]-enkephalin (DPDPE): pharmacokinetic consequences of the interplay between multiple transport systems.
Keith A Hoffmaster, Maciej J Zamek-Gliszczynski, Gary M Pollack, Kim L R Brouwer

J Pharmacol Exp Ther· December 2004

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P-glycoprotein expression, localization, and function in sandwich-cultured primary rat and human hepatocytes: relevance to the hepatobiliary disposition of a model opioid peptide.
Keith A Hoffmaster, Ryan Z Turncliff, Edward L LeCluyse, Richard B Kim, Peter J Meier

Pharm Res· July 2004

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Cytochrome P450 3A4 and P-glycoprotein mediate the interaction between an oral erythromycin breath test and rifampin.
Mary F Paine, David A Wagner, Keith A Hoffmaster, Paul B Watkins

Clin Pharmacol Ther· November 2002

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