Publications by authors named "Keith C Ellis"

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Combined inhibition of NAD synthesis and C-terminal binding protein cooperatively induces cell death and inhibits growth of high grade serous ovarian carcinoma.
Kranthi Kumar Chougoni, Jacqueline West, Nicholette St Martin, Diana Dcona, Istem Kose, Keith C Ellis

Sci Rep· December 2025

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Combined Targeting of NAD Biosynthesis and the NAD-dependent Transcription Factor C-terminal Binding Protein as a Promising Novel Therapy for Pancreatic Cancer.
M Michael Dcona, Kranthi Kumar Chougoni, Diana T Dcona, Jacqueline L West, Sahib J Singh, Keith C Ellis

Cancer Res Commun· October 2023

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Merging cultures and disciplines to create a drug discovery ecosystem at Virginia commonwealth university: Medicinal chemistry, structural biology, molecular and behavioral pharmacology and computational chemistry.
Glen E Kellogg, Yana Cen, Malgorzata Dukat, Keith C Ellis, Youzhong Guo

SLAS Discov· September 2023

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CtBP-a targetable dependency for tumor-initiating cell activity and metastasis in pancreatic adenocarcinoma.
Ayesha T Chawla, Kranthi Kumar Chougoni, Prashant J Joshi, Agnes D Cororaton, Patrick Memari, Keith C Ellis

Oncogenesis· October 2019

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Active-Site Tryptophan, the Target of Antineoplastic C-Terminal Binding Protein Inhibitors, Mediates Inhibitor Disruption of CtBP Oligomerization and Transcription Coregulatory Activities.
M Michael Dcona, Priyadarshan K Damle, Francisco Zarate-Perez, Benjamin L Morris, Zaid Nawaz, Keith C Ellis

Mol Pharmacol· July 2019

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An intestinal stem cell niche in mutated neoplasia targetable by CtBP inhibition.
Ayesha T Chawla, Agnes D Cororaton, Michael O Idowu, Priyadarshan K Damle, Barbara Szomju, Keith C Ellis

Oncotarget· August 2018

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Kinetics and inhibition studies of the L205R mutant of cAMP-dependent protein kinase involved in Cushing's syndrome.
Nicole M Luzi, Charles E Lyons, Darrell L Peterson, Keith C Ellis

FEBS Open Bio· April 2018

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Characterization of PKACα enzyme kinetics and inhibition in an HPLC assay with a chromophoric substrate.
Nicole M Luzi, Charles E Lyons, Darrell L Peterson, Keith C Ellis

Anal Biochem· September 2017

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CtBP- an emerging oncogene and novel small molecule drug target: Advances in the understanding of its oncogenic action and identification of therapeutic inhibitors.
M Michael Dcona, Benjamin L Morris, Keith C Ellis, Steven R Grossman

Cancer Biol Ther· June 2017

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Chelation-directed C-H activation/C-C bond forming reactions catalyzed by Pd(ii) nanoparticles supported on multiwalled carbon nanotubes.
Sudha Korwar, Michael Burkholder, Stanley E Gilliland, Kendra Brinkley, B Frank Gupton, Keith C Ellis

Chem Commun (Camb)· June 2017

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Design, synthesis, and biological evaluation of substrate-competitive inhibitors of C-terminal Binding Protein (CtBP).
Sudha Korwar, Benjamin L Morris, Hardik I Parikh, Robert A Coover, Tyler W Doughty, Keith C Ellis

Bioorg Med Chem· June 2016

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Design, synthesis, and in vitro evaluation of a fluorescently labeled irreversible inhibitor of the catalytic subunit of cAMP-dependent protein kinase (PKACα).
Robert A Coover, Nicole M Luzi, Sudha Korwar, Maria E Casile, Charles E Lyons, Keith C Ellis

Org Biomol Chem· May 2016

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Structure-guided design of a high affinity inhibitor to human CtBP.
Brendan J Hilbert, Benjamin L Morris, Keith C Ellis, Janet L Paulsen, Celia A Schiffer

ACS Chem Biol· April 2015

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Selective N-chelation-directed C-H activation reactions catalyzed by Pd(II) nanoparticles supported on multiwalled carbon nanotubes.
Sudha Korwar, Kendra Brinkley, Ali R Siamaki, B Frank Gupton, Keith C Ellis

Org Lett· April 2015

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Spin equilibrium and O₂-binding kinetics of Mycobacterium tuberculosis CYP51 with mutations in the histidine-threonine dyad.
Gareth K Jennings, Anuja Modi, Justin E Elenewski, Caroline M Ritchie, Thuy Nguyen, Keith C Ellis

J Inorg Biochem· July 2014

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Phenylalanine-Based Inactivator of AKT Kinase: Design, Synthesis, and Biological Evaluation.
Thuy Nguyen, Robert A Coover, Jenson Verghese, Richard G Moran, Keith C Ellis

ACS Med Chem Lett· May 2014

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Preparation and evaluation of deconstruction analogues of 7-deoxykalafungin as AKT kinase inhibitors.
Sudha Korwar, Thuy Nguyen, Keith C Ellis

Bioorg Med Chem Lett· January 2014

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Flavone-based analogues inspired by the natural product simocyclinone D8 as DNA gyrase inhibitors.
Jenson Verghese, Thuy Nguyen, Lisa M Oppegard, Lauren M Seivert, Hiroshi Hiasa, Keith C Ellis

Bioorg Med Chem Lett· November 2013

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Inhibition of human topoisomerases I and II by simocyclinone D8.
Lisa M Oppegard, Thuy Nguyen, Keith C Ellis, Hiroshi Hiasa

J Nat Prod· August 2012

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In vivo and in vitro patterns of the activity of simocyclinone D8, an angucyclinone antibiotic from Streptomyces antibioticus.
Lisa M Oppegard, Bree L Hamann, Kathryn R Streck, Keith C Ellis, Hans-Peter Fiedler

Antimicrob Agents Chemother· May 2009

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Enantiospecific synthesis and cytotoxicity of 7-(4-methoxyphenyl)-6-phenyl-2,3,8,8a-tetrahydroindolizin-5(1H)-one enantiomers.
F Scott Kimball, Brandon J Turunen, Keith C Ellis, Richard H Himes, Gunda I Georg

Bioorg Med Chem· April 2008

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Total synthesis of (-)- and (+)-membrenone C.
James A Marshall, Keith C Ellis

Org Lett· May 2003

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