Publications by authors named "Keith Caldecott"

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DNA2 enables growth by restricting recombination-restarted replication.
Jessica J R Hudson, Rowin Appanah, David Jones, Kathryn Davidson, Alice M Budden, Keith W Caldecott

Nature· October 2025

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Mechanism of cytarabine-induced neurotoxicity.
Jia-Cheng Liu, Dongpeng Wang, Elsa Callen, Chuanyuan Chen, Santiago Noriega, Keith W Caldecott

Nature· July 2025

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FEN1 is critical for rapid single-strand break repair in G1 phase.
Kamila Burdova, Richard Hailstone, Hana Hanzlikova, Keith W Caldecott

Nucleic Acids Res· July 2025

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Parp1 deletion rescues cerebellar hypotrophy in xrcc1 mutant zebrafish.
Svetlana A Semenova, Deepthi Nammi, Grace B Garrett, Gennady Margolin, Jennifer L Sinclair, Keith W Caldecott

Sci Rep· May 2025

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DNAR special issue: DNA damage responses and neurological disease The DNA damage response and neurological disease.
Keith Caldecott

DNA Repair (Amst)· January 2025

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deletion rescues cerebellar hypotrophy in mutant zebrafish.
Svetlana A Semenova, Deepthi Nammi, Grace A Garrett, Gennady Margolin, Jennifer L Sinclair, Keith W Caldecott

bioRxiv· November 2024

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Dispensability of HPF1 for cellular removal of DNA single-strand breaks.
Kristyna Hrychova, Kamila Burdova, Zuzana Polackova, Despoina Giamaki, Beatrice Valtorta, Keith W Caldecott

Nucleic Acids Res· October 2024

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KBM-mediated interactions with KU80 promote cellular resistance to DNA replication stress in CHO cells.
Sophie E Wells, Keith W Caldecott

DNA Repair (Amst)· August 2024

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PARP1-dependent DNA-protein crosslink repair.
Zita Fábián, Ellen S Kakulidis, Ivo A Hendriks, Ulrike Kühbacher, Nicolai B Larsen, Keith Caldecott

Nat Commun· August 2024

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DNA combing versus DNA spreading and the separation of sister chromatids.
Alice Meroni, Sophie E Wells, Carmen Fonseca, Arnab Ray Chaudhuri, Keith W Caldecott

J Cell Biol· April 2024

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Novel PNKP mutations associated with reduced DNA single-strand break repair and severe microcephaly, seizures, and developmental delay.
Ann-Charlotte Thuresson, Jan Brazina, Talia Akram, Julia Albrecht, Niklas Dahl, Keith W Caldecott

Mol Genet Genomic Med· January 2024

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Causes and consequences of DNA single-strand breaks.
Keith W Caldecott

Trends Biochem Sci· January 2024

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DNA damage and transcription stress.
Larissa Milano, Amit Gautam, Keith W Caldecott

Mol Cell· January 2024

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APE1-dependent base excision repair of DNA photodimers in human cells.
Amit Gautam, Heather Fawcett, Kamila Burdova, Jan Brazina, Keith W Caldecott

Mol Cell· October 2023

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Unrepaired base excision repair intermediates in template DNA strands trigger replication fork collapse and PARP inhibitor sensitivity.
Almudena Serrano-Benitez, Sophie E Wells, Lylah Drummond-Clarke, Lilian C Russo, John Christopher Thomas, Keith W Caldecott

EMBO J· September 2023

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Inactivating TDP2 missense mutation in siblings with congenital abnormalities reminiscent of fanconi anemia.
Guido Zagnoli-Vieira, Jan Brazina, Kris Van Den Bogaert, Wim Huybrechts, Guy Molenaers, Keith W Caldecott

Hum Genet· September 2023

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DNA Combing DNA Spreading and the Separation of Sister Chromatids.
Alice Meroni, Sophie E Wells, Carmen Fonseca, Arnab Ray Chaudhuri, Keith W Caldecott

bioRxiv· May 2023

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Active DNA demethylation promotes cell fate specification and the DNA damage response.
Dongpeng Wang, Wei Wu, Elsa Callen, Raphael Pavani, Nicholas Zolnerowich, Keith Caldecott

Science· December 2022

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DNA single-strand break repair and human genetic disease.
Keith W Caldecott

Trends Cell Biol· September 2022

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BRAT1 links Integrator and defective RNA processing with neurodegeneration.
Zuzana Cihlarova, Jan Kubovciak, Margarita Sobol, Katerina Krejcikova, Jana Sachova, Keith W Caldecott

Nat Commun· August 2022

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PARP inhibition impedes the maturation of nascent DNA strands during DNA replication.
Alina Vaitsiankova, Kamila Burdova, Margarita Sobol, Amit Gautam, Oldrich Benada, Keith W Caldecott

Nat Struct Mol Biol· April 2022

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The threat of programmed DNA damage to neuronal genome integrity and plasticity.
Keith W Caldecott, Michael E Ward, André Nussenzweig

Nat Genet· February 2022

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XRCC1 protects transcription from toxic PARP1 activity during DNA base excision repair.
Marek Adamowicz, Richard Hailstone, Annie A Demin, Emilia Komulainen, Hana Hanzlikova, Keith W Caldecott

Nat Cell Biol· December 2021

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Retraction Notice to: Sealing of Chromosomal DNA Nicks during Nucleotide Excision Repair Requires XRCC1 and DNA Ligase IIIα in a Cell-Cycle-Specific Manner.
Jill Moser, Hanneke Kool, Ioannis Giakzidis, Keith Caldecott, Leon H F Mullenders

Mol Cell· December 2021

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The SARS-CoV-2 Nsp3 macrodomain reverses PARP9/DTX3L-dependent ADP-ribosylation induced by interferon signaling.
Lilian Cristina Russo, Rebeka Tomasin, Isaac Araújo Matos, Antonio Carlos Manucci, Sven T Sowa, Keith W Caldecott

J Biol Chem· September 2021

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