Publications by authors named "Keith Chappell"

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Safety and immunogenicity of a SARS-CoV-2 spike, subunit vaccine stabilised in the prefusion conformation by second generation Molecular Clamp evaluated in adults aged 18-55 years: a randomised, double-blind, active comparator, Phase I trial.
Keith J Chappell, Francesca L Mordant, Alberto A Amarilla, Naphak Modhiran, Benjamin Liang

J Infect Dis· November 2025

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A nanobody-based therapeutic targeting Nipah virus limits viral escape.
Ariel Isaacs, Guillermo Valenzuela Nieto, Xinghai Zhang, Naphak Modhiran, Jennifer Barr, Keith J Chappell

Nat Struct Mol Biol· October 2025

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Temporal dynamics of koala retrovirus plasma RNA load in relation to faecal glucocorticoid metabolites and Chlamydia infection.
Michaela D J Blyton, Tamara Keeley, Lewis McKillop, Astrid Van Aggelen, Shali Fischer, Keith J Chappell

J Gen Virol· September 2025

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Adaptive evolution of koala retrovirus transcription silencing and what it means for conservation.
Keith J Chappell, Michaela B J Blyton, Zhiping Weng, William E Theurkauf

Clin Transl Med· July 2025

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A second-generation molecular clamp stabilised bivalent candidate vaccine for protection against diseases caused by respiratory syncytial virus and human metapneumovirus.
Andrew Young, Sharada Kolekar, Carlos Alvarez Mendoza, Noushin Jaberolansar, Naphak Modhiran, Keith J Chappell

PLoS Pathog· July 2025

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Nipah virus vaccines evaluated in pigs as a 'One Health' approach to protect public health.
Rebecca K McLean, Miriam Pedrera, Nazia Thakur, Ahmed M E Elrefaey, Sophia Hodgson, Keith Chappell

NPJ Vaccines· July 2025

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Evolution of KoRV-A transcriptional silencing in wild koalas.
Tianxiong Yu, Michaela B J Blyton, Milky Abajorga, Birgit S Koppetsch, Samantha Ho, Keith Chappell

Cell· April 2025

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The Trajectory of KoRV-A Evolution Indicates Initial Integration into the Koala Germline Genome Near Coffs Harbour.
Tianxiong Yu, Michaela B J Blyton, Birgit S Koppetsch, Milky Abajorga, Jeremy Luban, Keith Chappell

Res Sq· December 2024

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Human T-lymphotropic virus type 1 and antiretroviral therapy: practical considerations for pre-exposure and post-exposure prophylaxis, transmission prevention, and mitigation of severe disease.
Jake S O'Donnell, Noushin Jaberolansar, Keith J Chappell

Lancet Microbe· April 2024

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The role of N-glycosylation in spike antigenicity for the SARS-CoV-2 gamma variant.
Cassandra L Pegg, Naphak Modhiran, Rhys H Parry, Benjamin Liang, Alberto A Amarilla, Keith Chappell

Glycobiology· March 2024

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HTLV-1 reverse transcriptase homology model provides structural basis for sensitivity to existing nucleoside/nucleotide reverse transcriptase inhibitors.
Nicolas Tardiota, Noushin Jaberolansar, Julia A Lackenby, Keith J Chappell, Jake S O'Donnell

Virol J· January 2024

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Broad protection from SARS-CoV-2 variants without antigen matching.
Keith Chappell

Lancet Respir Med· November 2023

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Long-term safety and immunogenicity of an MF59-adjuvanted spike glycoprotein-clamp vaccine for SARS-CoV-2 in adults aged 18-55 years or ≥56 years: 12-month results from a randomised, double-blind, placebo-controlled, phase 1 trial.
Keith J Chappell, Francesca L Mordant, Alberto A Amarilla, Naphak Modhiran, Benjamin Liang

EBioMedicine· November 2023

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SARS-CoV-2 drives NLRP3 inflammasome activation in human microglia through spike protein.
Eduardo A Albornoz, Alberto A Amarilla, Naphak Modhiran, Sandra Parker, Xaria X Li, Keith J Chappell

Mol Psychiatry· July 2023

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A nanobody recognizes a unique conserved epitope and potently neutralizes SARS-CoV-2 omicron variants.
Naphak Modhiran, Simon Malte Lauer, Alberto A Amarilla, Peter Hewins, Sara Irene Lopes van den Broek, Keith Chappell

iScience· July 2023

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Integrated molecular and immunological features of human T-lymphotropic virus type 1 infection and disease progression to adult T-cell leukaemia or lymphoma.
Jake S O'Donnell, Stewart K Hunt, Keith J Chappell

Lancet Haematol· July 2023

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Structure and antigenicity of divergent Henipavirus fusion glycoproteins.
Ariel Isaacs, Yu Shang Low, Kyle L Macauslane, Joy Seitanidou, Cassandra L Pegg, Keith J Chappell

Nat Commun· June 2023

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A platform technology for generating subunit vaccines against diverse viral pathogens.
Andrew Young, Ariel Isaacs, Connor A P Scott, Naphak Modhiran, Christopher L D McMillan, Keith J Chappell

Front Immunol· September 2022

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Characterization and comparison of novel adjuvants for a prefusion clamped MERS vaccine.
Jake S O'Donnell, Ariel Isaacs, Virginie Jakob, Celia Lebas, James B Barnes, Keith J Chappell

Front Immunol· September 2022

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Diversity and transmission of koala retrovirus: a case study in three captive koala populations.
Briony A Joyce, Michaela D J Blyton, Stephen D Johnston, William D Meikle, Kimberly Vinette Herrin, Keith J Chappell

Sci Rep· September 2022

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Geographic patterns of koala retrovirus genetic diversity, endogenization, and subtype distributions.
Michaela D J Blyton, Paul R Young, Ben D Moore, Keith J Chappell

Proc Natl Acad Sci U S A· August 2022

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Editorial: Emerging and re-emerging viral zoonoses.
Naveen Kumar, Vladimir N Uversky, Shailly Tomar, Kenneth S M Li, Keith Chappell

Front Microbiol· August 2022

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Nucleocapsid Specific Diagnostics for the Detection of Divergent SARS-CoV-2 Variants.
Ariel Isaacs, Alberto A Amarilla, Julio Aguado, Naphak Modhiran, Eduardo A Albornoz, Keith J Chappell

Front Immunol· June 2022

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Koala retrovirus load and non-A subtypes are associated with secondary disease among wild northern koalas.
Michaela D J Blyton, Michael Pyne, Paul Young, Keith Chappell

PLoS Pathog· May 2022

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Peptide-Based Vaccine against SARS-CoV-2: Peptide Antigen Discovery and Screening of Adjuvant Systems.
Ahmed O Shalash, Armira Azuar, Harrison Y R Madge, Naphak Modhiran, Alberto A Amarilla, Keith J Chappell

Pharmaceutics· April 2022

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