Publications by authors named "Keith Hamel"

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Mechanistic insights into a heterobifunctional degrader-induced PTPN2/N1 complex.
Qi Hao, Manoj K Rathinaswamy, Kelly L Klinge, Matthew Bratkowski, Amirhossein Mafi, Keith M Hamel

Commun Chem· August 2024

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The PTPN2/PTPN1 inhibitor ABBV-CLS-484 unleashes potent anti-tumour immunity.
Christina K Baumgartner, Hakimeh Ebrahimi-Nik, Arvin Iracheta-Vellve, Keith M Hamel, Kira E Olander

Nature· October 2023

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Venetoclax Increases Intratumoral Effector T Cells and Antitumor Efficacy in Combination with Immune Checkpoint Blockade.
Frederick J Kohlhapp, Dipica Haribhai, Rebecca Mathew, Ryan Duggan, Paul A Ellis, Keith M Hamel

Cancer Discov· January 2021

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Igβ ubiquitination activates PI3K signals required for endosomal sorting.
Margaret Veselits, Azusa Tanaka, Yaoqing Chen, Keith Hamel, Malay Mandal

J Exp Med· December 2017

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Histone reader BRWD1 targets and restricts recombination to the Igk locus.
Malay Mandal, Keith M Hamel, Mark Maienschein-Cline, Azusa Tanaka, Grace Teng

Nat Immunol· October 2015

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B cells expressing IFN-γ suppress Treg-cell differentiation and promote autoimmune experimental arthritis.
Susan A Olalekan, Yanxia Cao, Keith M Hamel, Alison Finnegan

Eur J Immunol· April 2015

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Balancing Proliferation with Igκ Recombination during B-lymphopoiesis.
Keith M Hamel, Malay Mandal, Sophiya Karki, Marcus R Clark

Front Immunol· June 2014

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B cell-specific expression of inducible costimulator ligand is necessary for the induction of arthritis in mice.
Keith M Hamel, Yanxia Cao, Susan A Olalekan, Alison Finnegan

Arthritis Rheumatol· January 2014

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Germinal center B-cells.
Keith M Hamel, Vladimir M Liarski, Marcus R Clark

Autoimmunity· August 2012

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B effector cells in rheumatoid arthritis and experimental arthritis.
Alison Finnegan, Susan Ashaye, Keith M Hamel

Autoimmunity· August 2012

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B cell depletion enhances T regulatory cell activity essential in the suppression of arthritis.
Keith M Hamel, Yanxia Cao, Susan Ashaye, Yumei Wang, Robert Dunn

J Immunol· November 2011

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Epigenetic repression of the Igk locus by STAT5-mediated recruitment of the histone methyltransferase Ezh2.
Malay Mandal, Sarah E Powers, Mark Maienschein-Cline, Elizabeth T Bartom, Keith M Hamel

Nat Immunol· October 2011

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B7-H1 expression on non-B and non-T cells promotes distinct effects on T- and B-cell responses in autoimmune arthritis.
Keith M Hamel, Yanxia Cao, Yumei Wang, Rachel Rodeghero, Tamas Kobezda

Eur J Immunol· November 2010

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IFN-gamma regulates the requirement for IL-17 in proteoglycan-induced arthritis.
Paul D Doodes, Yanxia Cao, Keith M Hamel, Yumei Wang, Rachel L Rodeghero

J Immunol· February 2010

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CCR5 is involved in resolution of inflammation in proteoglycan-induced arthritis.
Paul D Doodes, Yanxia Cao, Keith M Hamel, Yumei Wang, Rachel L Rodeghero

Arthritis Rheum· October 2009

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Effects of active immunization against growth differentiation factor 9 and/or bone morphogenetic protein 15 on ovarian function in cattle.
Jennifer L Juengel, Norma L Hudson, Martin Berg, Keith Hamel, Peter Smith

Reproduction· July 2009

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Development of proteoglycan-induced arthritis is independent of IL-17.
Paul D Doodes, Yanxia Cao, Keith M Hamel, Yumei Wang, Balint Farkas

J Immunol· July 2008

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Suppression of proteoglycan-induced arthritis by anti-CD20 B Cell depletion therapy is mediated by reduction in autoantibodies and CD4+ T cell reactivity.
Keith Hamel, Paul Doodes, Yanxia Cao, Yumei Wang, Jeffrey Martinson

J Immunol· April 2008

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Expression of CD80/86 on B cells is essential for autoreactive T cell activation and the development of arthritis.
Shannon K O'Neill, Yanxia Cao, Keith M Hamel, Paul D Doodes, Gabor Hutas

J Immunol· October 2007

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