Publications by authors named "Keith Humphries"

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Transcriptional control of leukemogenesis by the chromatin reader SGF29.
Karina Barbosa, Anagha Deshpande, Marlenne Perales, Ping Xiang, Rabi Murad, R Keith Humphries

Blood· February 2024

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Meis1 establishes the pre-hemogenic endothelial state prior to Runx1 expression.
Patrick Coulombe, Grace Cole, Amanda Fentiman, Jeremy D K Parker, Eric Yung, R Keith Humphries

Nat Commun· July 2023

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Elucidating the importance and regulation of key enhancers for human MEIS1 expression.
Ping Xiang, Xining Yang, Leo Escano, Ishpreet Dhillon, Edith Schneider, R Keith Humphries

Leukemia· August 2022

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Reversible switching of leukemic cells to a drug-resistant, stem-like subset via IL-4-mediated cross-talk with mesenchymal stroma.
Hae-Ri Lee, Ga-Young Lee, Eung-Won Kim, Hee-Je Kim, Minho Lee, R Keith Humphries

Haematologica· February 2022

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Correction: Effective drug treatment identified by in vivo screening in a transplantable patient-derived xenograft model of chronic myelomonocytic leukemia.
Arnold Kloos, Konstantinos Mintzas, Lina Winckler, Razif Gabdoulline, Yasmine Alwie, R Keith Humphries

Leukemia· December 2021

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Epigenetic and functional changes imposed by NUP98-HOXA9 in a genetically engineered model of chronic myeloid leukemia progression.
Ivan Sloma, Philip Beer, Christophe Desterke, Elizabeth Bulaeva, Misha Bilenky, Keith Humphries

Haematologica· March 2021

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Effective drug treatment identified by in vivo screening in a transplantable patient-derived xenograft model of chronic myelomonocytic leukemia.
Arnold Kloos, Konstantinos Mintzas, Lina Winckler, Razif Gabdoulline, Yasmine Alwie, R Keith Humphries

Leukemia· November 2020

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The miR-185/PAK6 axis predicts therapy response and regulates survival of drug-resistant leukemic stem cells in CML.
Hanyang Lin, Katharina Rothe, Min Chen, Andrew Wu, Artem Babaian, R Keith Humphries

Blood· July 2020

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MicroRNA-708 is a novel regulator of the Hoxa9 program in myeloid cells.
Edith Schneider, Nicole Pochert, Christoph Ruess, Liam MacPhee, Leo Escano, R Keith Humphries

Leukemia· May 2020

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Human models of NUP98-KDM5A megakaryocytic leukemia in mice contribute to uncovering new biomarkers and therapeutic vulnerabilities.
Sophie Cardin, Mélanie Bilodeau, Mathieu Roussy, Léo Aubert, Thomas Milan, R Keith Humphries

Blood Adv· November 2019

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Lipid nanoparticle-mediated siRNA delivery for safe targeting of human CML in vivo.
Nidhi Jyotsana, Amit Sharma, Anuhar Chaturvedi, Ramachandramouli Budida, Michaela Scherr, R Keith Humphries

Ann Hematol· August 2019

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Hepatic leukemia factor is a novel leukemic stem cell regulator in DNMT3A, NPM1, and FLT3-ITD triple-mutated AML.
Swati Garg, Armando Reyes-Palomares, Lixiazi He, Anne Bergeron, Vincent-Philippe Lavallée, R Keith Humphries

Blood· July 2019

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Synthetic modeling reveals HOXB genes are critical for the initiation and maintenance of human leukemia.
Manabu Kusakabe, Ann Chong Sun, Kateryna Tyshchenko, Rachel Wong, Aastha Nanda, R Keith Humphries

Nat Commun· July 2019

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Endothelial Sash1 Is Required for Lung Maturation through Nitric Oxide Signaling.
Patrick Coulombe, Grigorios N Paliouras, Ashley Clayton, Angela Hussainkhel, Megan Fuller, R Keith Humphries

Cell Rep· May 2019

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Single-cell analysis identifies a CD33 subset of human cord blood cells with high regenerative potential.
David J H F Knapp, Colin A Hammond, Tony Hui, Marijn T J van Loenhout, Fangwu Wang, R Keith Humphries

Nat Cell Biol· June 2018

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Endogenous Tumor Suppressor microRNA-193b: Therapeutic and Prognostic Value in Acute Myeloid Leukemia.
Raj Bhayadia, Kathrin Krowiorz, Nadine Haetscher, Razan Jammal, Stephan Emmrich, R Keith Humphries

J Clin Oncol· April 2018

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Micro-ribonucleic acid-155 is a direct target of Meis1, but not a driver in acute myeloid leukemia.
Edith Schneider, Anna Staffas, Linda Röhner, Erik D Malmberg, Arghavan Ashouri, R Keith Humphries

Haematologica· February 2018

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A knock-in mouse strain facilitates dynamic tracking and enrichment of MEIS1.
Ping Xiang, Wei Wei, Nicole Hofs, Jack Clemans-Gibbon, Tobias Maetzig, R Keith Humphries

Blood Adv· November 2017

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Lentiviral Fluorescent Genetic Barcoding for Multiplex Fate Tracking of Leukemic Cells.
Tobias Maetzig, Jens Ruschmann, Lea Sanchez Milde, Courteney K Lai, Niklas von Krosigk, R Keith Humphries

Mol Ther Methods Clin Dev· September 2017

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Targeted therapy for a subset of acute myeloid leukemias that lack expression of aldehyde dehydrogenase 1A1.
Maura Gasparetto, Shanshan Pei, Mohammad Minhajuddin, Nabilah Khan, Daniel A Pollyea, Keith R Humphries

Haematologica· June 2017

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Analysis of parameters that affect human hematopoietic cell outputs in mutant c-kit-immunodeficient mice.
Paul H Miller, Gabrielle Rabu, Margarita MacAldaz, David J H F Knapp, Alice M S Cheung, R Keith Humphries

Exp Hematol· April 2017

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Hoxa9 and Meis1 Cooperatively Induce Addiction to Syk Signaling by Suppressing miR-146a in Acute Myeloid Leukemia.
Sebastian Mohr, Carmen Doebele, Federico Comoglio, Tobias Berg, Julia Beck, R Keith Humphries

Cancer Cell· April 2017

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Lentiviral Transfer of γ-Globin with Fusion Gene NUP98-HOXA10HD Expands Hematopoietic Stem Cells and Ameliorates Murine β-Thalassemia.
Hui Fen Zhao, Allistair Abraham, Yoon-Sang Kim, Yong-Dong Wang, Tamara Pestina, Keith Humphries

Mol Ther· March 2017

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Editorial.
R Keith Humphries, Connie Eaves

Exp Hematol· March 2017

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A Lentiviral Fluorescent Genetic Barcoding System for Flow Cytometry-Based Multiplex Tracking.
Tobias Maetzig, Jens Ruschmann, Courteney K Lai, Mor Ngom, Suzan Imren, R Keith Humphries

Mol Ther· March 2017

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