Publications by authors named "Keith Jendza"

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Transaminases Provide Key Chiral Building Blocks for the Synthesis of Selective M1/M4 Agonists.
Christopher G Thomson, Kelly Boss, Amy Calhoun, Cary Fridrich, Kevin M Gardinier, Keith Jendza

ACS Med Chem Lett· December 2023

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Discovery of 4-((2,4)-4-Ethoxy-1-((5-methoxy-7-methyl-1-indol-4-yl)methyl)piperidin-2-yl)benzoic Acid (LNP023), a Factor B Inhibitor Specifically Designed To Be Applicable to Treating a Diverse Array of Complement Mediated Diseases.
Nello Mainolfi, Takeru Ehara, Rajeshri G Karki, Karen Anderson, Aengus Mac Sweeney, Keith Jendza

J Med Chem· June 2020

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A small-molecule inhibitor of C5 complement protein.
Keith Jendza, Mitsunori Kato, Michael Salcius, Honnappa Srinivas, Andrea De Erkenez

Nat Chem Biol· July 2019

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Design, Synthesis, and Preclinical Characterization of Selective Factor D Inhibitors Targeting the Alternative Complement Pathway.
Rajeshri G Karki, James Powers, Nello Mainolfi, Karen Anderson, David B Belanger, Keith Jendza

J Med Chem· May 2019

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Discovery of TD-0212, an Orally Active Dual Pharmacology AT Antagonist and Neprilysin Inhibitor (ARNI).
R Murray McKinnell, Paul Fatheree, Seok-Ki Choi, Roland Gendron, Keith Jendza

ACS Med Chem Lett· January 2019

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The Discovery of N-(1-Methyl-5-(trifluoromethyl)-1H-pyrazol-3-yl)-5-((6- ((methylamino)methyl)pyrimidin-4-yl)oxy)-1H-indole-1-carboxamide (Acrizanib), a VEGFR-2 Inhibitor Specifically Designed for Topical Ocular Delivery, as a Therapy for Neovascular Age-Related Macular Degeneration.
Christopher M Adams, Karen Anderson, Gerald Artman, Jean-Claude Bizec, Rosemarie Cepeda, Keith Jendza

J Med Chem· February 2018

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The versatility of alpha-chloropropargyl phenyl sulfide affords high stereo- and regioselectivities in indium-promoted coupling reactions under mild conditions.
Thomas M Mitzel, Carolyn Palomo, Keith Jendza

J Org Chem· January 2002

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