Publications by authors named "Kelley Mark"

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A Phase I study targeting the APE1/ref-1 redox signaling protein with APX3330: First clinical agent targeting APE1/ref-1 in Cancer.
Mark R Kelley, Jun Wan, Sheng Liu, Eyram Kpenu, Randall Wireman

Oncologist· December 2025

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Genomic copy-number variants drive apoptotic evasion underlying acquired resistance to immune checkpoint inhibitors.
Mingming Wu, Shiyue Yang, Zhentao Yang, Jian Fan, Shirley H Lomeli, Mark C Kelley

Immunity· November 2025

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The absence of Peroxiredoxin-1 in human pancreatic ductal adenocarcinoma (PDAC) markedly reduces cell survival and tumor growth when coupled with the inhibition of Ref-1 redox signaling.
Sonia Kiran, Randall S Wireman, Jacqueline Peil, Dana K Mitchell, Elizabeth Sierra Potchanant, Mark R Kelley

Redox Biol· October 2025

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Ref-1 redox activity modulates canonical Wnt signaling in endothelial cells.
Gabriella D Hartman, Kamakshi Sishtla, Eyram K Kpenu, Mahmut Mijit, Anbukkarasi Muniyandi, Mark R Kelley

Redox Biol· June 2025

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Chemically induced partial unfolding of the multifunctional apurinic/apyrimidinic endonuclease 1.
Ratan Rai, Olabode I Dawodu, Jingwei Meng, Steven M Johnson, Jonah Z Vilseck, Mark R Kelley

Protein Sci· June 2025

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A Phase I study targeting the APE1/Ref-1 redox signaling protein with APX3330: First clinical agent targeting APE1/Ref-1 in Cancer.
Mark R Kelley, Jun Wan, Sheng Liu, Eyram Kpenu, Randall Wireman

medRxiv· April 2025

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Chemically induced partial unfolding of the multifunctional Apurinic/apyrimidinic endonuclease 1.
Ratan Rai, Olabode I Dawodu, Jingwei Meng, Steven M Johnson, Jonah Z Vilseck, Mark R Kelley

bioRxiv· March 2025

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Disease recurrence in patients undergoing mastectomy for ductal carcinoma in situ.
Marissa C Kuo, Jessica Sims, Odette K Solis, Ingrid M Meszoely, Raeshell S Sweeting, Mark C Kelley

Breast Cancer Res Treat· February 2025

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Ref-1 redox activity regulates retinal neovascularization by modulating transcriptional activation of HIF-1α.
Gabriella D Hartman, Anbukkarasi Muniyandi, Kamakshi Sishtla, Eyram K Kpenu, William P Miller, Mark R Kelley

FASEB J· February 2025

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Ref-1 is overexpressed in neovascular eye disease and targetable with a novel inhibitor.
Anbukkarasi Muniyandi, Gabriella D Hartman, Kamakshi Sishtla, Ratan Rai, Cátia Gomes, Mark R Kelley

Angiogenesis· January 2025

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Early-stage Development of the CoRISMA Mechanical Circulatory Support (CMCS) System for Heart Failure Therapy.
Gretel Monreal, Steven C Koenig, James F Kelley, Jessica J Illg, Daniel Tamez, Mark S Kelley, Mark S Slaughter

Cardiovasc Eng Technol· December 2024

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Cost containment analysis of superparamagnetic iron oxide (SPIO) injection in patients with ductal carcinoma in situ.
Odette Solís, Jamin Addae, Raeshell Sweeting, Ingrid Meszoely, Ana Grau, Mark Kelley

Breast Cancer Res Treat· December 2024

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An Empirical Evaluation of Prompting Strategies for Large Language Models in Zero-Shot Clinical Natural Language Processing: Algorithm Development and Validation Study.
Sonish Sivarajkumar, Mark Kelley, Alyssa Samolyk-Mazzanti, Shyam Visweswaran, Yanshan Wang

JMIR Med Inform· April 2024

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New Ref-1/APE1 targeted inhibitors demonstrating improved potency for clinical applications in multiple cancer types.
Silpa Gampala, Hye-Ran Moon, Randall Wireman, Jacqueline Peil, Sonia Kiran, Mark R Kelley

Pharmacol Res· March 2024

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Genital Tucking Practices in Transgender and Gender Diverse Patients.
Nicholas Kidd, Kelley Mark, Marina Dart, Catherine Casey, Lisa Rollins

Ann Fam Med· March 2024

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Superparamagnetic iron oxide (SPIO) for axillary mapping in patients with ductal carcinoma in situ undergoing mastectomy: single-institution experience.
Jamin Kweku Addae, Raeshell Sharawn Sweeting, Ingrid Marie Meszoely, Rachel Louise McCaffrey, Rondi Marie Kauffmann, Mark Carlton Kelley

Breast Cancer Res Treat· February 2024

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Observational Analysis of the Influence of Medical Marijuana Use on Quality of Life in Patients.
Mark D Kelley, Marwah Obaid, Edward M Miller, Marla Bowie, Zachary S Heeter

Med Cannabis Cannabinoids· February 2024

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Bridging population pharmacokinetic and semimechanistic absorption modeling of APX3330.
Larissa L Silva, Robert E Stratford, Richard Messmann, Mark R Kelley, Sara K Quinney

CPT Pharmacometrics Syst Pharmacol· January 2024

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Combating PDAC Drug Resistance: The Role of Ref-1 Inhibitors in Accelerating Progress in Pancreatic Cancer Research.
Eyram K Kpenu, Mark R Kelley

J Cell Signal· January 2024

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APE1/Ref-1 as a Therapeutic Target for Inflammatory Bowel Disease.
Lauren Sahakian, Ainsley M Robinson, Linda Sahakian, Rhian Stavely, Mark R Kelley

Biomolecules· October 2023

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Beyond VEGF: Targeting Inflammation and Other Pathways for Treatment of Retinal Disease.
Anbukkarasi Muniyandi, Gabriella D Hartman, Yang Song, Mahmut Mijit, Mark R Kelley

J Pharmacol Exp Ther· July 2023

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Regarding: Predicting Regional Lymph Node Recurrence in The Modern Age of Tumor-Positive Sentinel Node Melanoma.
John F Thompson, John Hyngstrom, Corrado Caracò, Jonathan S Zager, Tiina Jahkola, Mark C Kelley, B Mark Smithers, Mark B Faries

Ann Surg Oncol· July 2023

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Activation of the integrated stress response (ISR) pathways in response to Ref-1 inhibition in human pancreatic cancer and its tumor microenvironment.
Mahmut Mijit, Megan Boner, Ricardo A Cordova, Silpa Gampala, Eyram Kpenu, MarK R Kelley

Front Med (Lausanne)· April 2023

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Identification of Novel Pathways Regulated by APE1/Ref-1 in Human Retinal Endothelial Cells.
Mahmut Mijit, Sheng Liu, Kamakshi Sishtla, Gabriella D Hartman, Jun Wan, Mark R Kelley

Int J Mol Sci· January 2023

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Inhibition of PRMT5 by market drugs as a novel cancer therapeutic avenue.
Lakshmi Prabhu, Matthew Martin, Lan Chen, Özlem Demir, Jiamin Jin, Mark R Kelley

Genes Dis· January 2023

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