Publications by authors named "Kelly A O'Connell"

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PR55α subunit of protein phosphatase 2A supports KRAS-driven tumorigenesis that requires YAP activation.
Christopher B Jenkins, Alison L Camero, Brendan T Graff, Lepakshe S V Madduri, Kelly A O'Connell

Oncogene· September 2025

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Visceral adipose tissue remodeling in pancreatic ductal adenocarcinoma cachexia: the role of activin A signaling.
Pauline C Xu, Mikyoung You, Seok-Yeong Yu, Yi Luan, Maya Eldani, Kelly A O'Connell

Sci Rep· January 2022

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IgE-Based Therapeutic Combination Enhances Antitumor Response in Preclinical Models of Pancreatic Cancer.
Spas Dimitrov Markov, Thomas C Caffrey, Kelly A O'Connell, James A Grunkemeyer, Simon Shin

Mol Cancer Ther· December 2021

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Heme Oxygenase-1 Inhibition Potentiates the Effects of Nab-Paclitaxel-Gemcitabine and Modulates the Tumor Microenvironment in Pancreatic Ductal Adenocarcinoma.
Iman M Ahmad, Alicia J Dafferner, Kelly A O'Connell, Kamiya Mehla, Bradley E Britigan

Cancers (Basel)· May 2021

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Isoforms of MUC16 activate oncogenic signaling through EGF receptors to enhance the progression of pancreatic cancer.
Divya Thomas, Satish Sagar, Xiang Liu, Hye-Rim Lee, James A Grunkemeyer, Kelly A O'Connell

Mol Ther· April 2021

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Inhibition of the Receptor for Advanced Glycation End Products Enhances the Cytotoxic Effect of Gemcitabine in Murine Pancreatic Tumors.
Priyanka Swami, Kelly A O'Connell, Swetha Thiyagarajan, Ayrianne Crawford, Prathamesh Patil

Biomolecules· April 2021

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A Polymeric Nanogel-Based Treatment Regimen for Enhanced Efficacy and Sequential Administration of Synergistic Drug Combination in Pancreatic Cancer.
Kruti S Soni, Divya Thomas, Thomas Caffrey, Kamiya Mehla, Fan Lei, Kelly A O'Connell

J Pharmacol Exp Ther· September 2019

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Combination of mAb-AR20.5, anti-PD-L1 and PolyICLC inhibits tumor progression and prolongs survival of MUC1.Tg mice challenged with pancreatic tumors.
Kamiya Mehla, Jarrod Tremayne, James A Grunkemeyer, Kelly A O'Connell, Maria M Steele

Cancer Immunol Immunother· March 2018

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MitoQ improves mitochondrial dysfunction in heart failure induced by pressure overload.
Rogério Faustino Ribeiro Junior, Erinne Rose Dabkowski, Kadambari Chandra Shekar, Kelly A O Connell, Peter A Hecker

Free Radic Biol Med· March 2018

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Deregulated Ca cycling underlies the development of arrhythmia and heart disease due to mutant obscurin.
Li-Yen R Hu, Maegen A Ackermann, Peter A Hecker, Benjamin L Prosser, Brendan King, Kelly A O'Connell

Sci Adv· June 2017

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PKC δ and βII regulate angiotensin II-mediated fibrosis through p38: a mechanism of RV fibrosis in pulmonary hypertension.
Havovi Chichger, Alexander Vang, Kelly A O'Connell, Peng Zhang, Ulrike Mende

Am J Physiol Lung Cell Mol Physiol· April 2015

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Effect of a high-protein diet on development of heart failure in response to pressure overload.
Rogerio F Ribeiro, Erinne R Dabkowski, Kelly A O'Connell, Wenhong Xu, Tatiana de Fatima Galvao

Appl Physiol Nutr Metab· February 2014

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Docosahexaenoic acid supplementation alters key properties of cardiac mitochondria and modestly attenuates development of left ventricular dysfunction in pressure overload-induced heart failure.
Erinne R Dabkowski, Kelly A O'Connell, Wenhong Xu, Eduardo Hertel Ribeiro, Peter A Hecker

Cardiovasc Drugs Ther· December 2013

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Evaluation of docosahexaenoic acid in a dog model of hypertension induced left ventricular hypertrophy.
William C Stanley, James W Cox, Girma Asemu, Kelly A O'Connell, Erinne R Dabkowski

J Cardiovasc Transl Res· December 2013

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Dietary saturated fat and docosahexaenoic acid differentially effect cardiac mitochondrial phospholipid fatty acyl composition and Ca(2+) uptake, without altering permeability transition or left ventricular function.
Kelly A O'Connell, Erinne R Dabkowski, Tatiana de Fatima Galvao, Wenhong Xu, Caroline Daneault

Physiol Rep· June 2013

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Cardiomyocyte-specific perilipin 5 overexpression leads to myocardial steatosis and modest cardiac dysfunction.
Hong Wang, Urmila Sreenivasan, Da-Wei Gong, Kelly A O'Connell, Erinne R Dabkowski

J Lipid Res· April 2013

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Enhanced resistance to permeability transition in interfibrillar cardiac mitochondria in dogs: effects of aging and long-term aldosterone infusion.
Girma Asemu, Kelly A O'Connell, James W Cox, Erinne R Dabkowski, Wenhong Xu

Am J Physiol Heart Circ Physiol· February 2013

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Marine n3 polyunsaturated fatty acids enhance resistance to mitochondrial permeability transition in heart failure but do not improve survival.
Tatiana F Galvao, Ramzi J Khairallah, Erinne R Dabkowski, Bethany H Brown, Peter A Hecker, Kelly A O'Connell

Am J Physiol Heart Circ Physiol· January 2013

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Glucose 6-phosphate dehydrogenase deficiency increases redox stress and moderately accelerates the development of heart failure.
Peter A Hecker, Vincenzo Lionetti, Rogerio F Ribeiro, Sharad Rastogi, Bethany H Brown, Kelly A O'Connell

Circ Heart Fail· January 2013

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Effects of glucose-6-phosphate dehydrogenase deficiency on the metabolic and cardiac responses to obesogenic or high-fructose diets.
Peter A Hecker, Rudo F Mapanga, Charlene P Kimar, Rogerio F Ribeiro, Bethany H Brown, Kelly A O'Connell

Am J Physiol Endocrinol Metab· October 2012

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Improved mitochondrial function with diet-induced increase in either docosahexaenoic acid or arachidonic acid in membrane phospholipids.
Ramzi J Khairallah, Junhwan Kim, Karen M O'Shea, Kelly A O'Connell, Bethany H Brown

PLoS One· July 2012

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Dietary fat and heart failure: moving from lipotoxicity to lipoprotection.
William C Stanley, Erinne R Dabkowski, Rogerio F Ribeiro, Kelly A O'Connell

Circ Res· March 2012

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High intake of saturated fat, but not polyunsaturated fat, improves survival in heart failure despite persistent mitochondrial defects.
Tatiana F Galvao, Bethany H Brown, Peter A Hecker, Kelly A O'Connell, Karen M O'Shea

Cardiovasc Res· January 2012

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Cardiomyocyte deletion of mitofusin-1 leads to mitochondrial fragmentation and improves tolerance to ROS-induced mitochondrial dysfunction and cell death.
Kyriakos N Papanicolaou, Gladys A Ngoh, Erinne R Dabkowski, Kelly A O'Connell, Rogerio F Ribeiro

Am J Physiol Heart Circ Physiol· January 2012

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Submandibular gland acinar cells express multiple alpha1-adrenoceptor subtypes.
Charles S Bockman, Michael R Bruchas, Wanyun Zeng, Kelly A O'Connell, Peter W Abel

J Pharmacol Exp Ther· October 2004

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