Publications by authors named "Kelly George"

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Novel transferrin receptor-mediated enzyme replacement therapy efficiently treats myogenic and neurogenic aspects of Pompe disease in mice.
Kelly George, Raquel Riley, Shan Zhou, Elizabeth Allen, Laurie Smith

Mol Ther Methods Clin Dev· September 2025

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Corrigendum to "Pompe disease: Unmet needs and emerging therapies" [Mol Genet Metab. 2024 Nov;143(3):108590].
Kelly A George, Allyson L Anding, Arjan van der Flier, Giulio S Tomassy, Kenneth I Berger

Mol Genet Metab· April 2025

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Quantitative Systems Pharmacology-Based Digital Twins Approach Supplements Clinical Trial Data for Enzyme Replacement Therapies in Pompe Disease.
Chanchala Kaddi, Mengdi Tao, Silke Bergeler, Kelly George, Hugo Geerts

Clin Pharmacol Ther· February 2025

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Pompe disease: Unmet needs and emerging therapies.
Kelly A George, Allyson L Anding, Arjan van der Flier, Giulio S Tomassy, Kenneth I Berger

Mol Genet Metab· November 2024

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Suppressed basal mitophagy drives cellular aging phenotypes that can be reversed by a p62-targeting small molecule.
George Kelly, Tetsushi Kataura, Johan Panek, Gailing Ma, Hanna Salmonowicz

Dev Cell· August 2024

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The impact of sphingomyelin on the pathophysiology and treatment response to olipudase alfa in acid sphingomyelinase deficiency.
Monica Kumar, Mario Aguiar, Andreas Jessel, Beth L Thurberg, Lisa Underhill, Kelly George

Genet Med Open· August 2024

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Response to Comments on "Increasing Enzyme Mannose-6-Phosphate Levels but Not Miglustat Coadministration Enhances the Efficacy of Enzyme Replacement Therapy in Pompe Mice".
Kelly George, Allyson Anding

J Pharmacol Exp Ther· May 2024

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Author Correction: Apoptotic stress causes mtDNA release during senescence and drives the SASP.
Stella Victorelli, Hanna Salmonowicz, James Chapman, Helene Martini, Maria Grazia Vizioli, George Kelly

Nature· January 2024

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Increasing Enzyme Mannose-6-Phosphate Levels but Not Miglustat Coadministration Enhances the Efficacy of Enzyme Replacement Therapy in Pompe Mice.
Allyson Anding, Sofia Kinton, Kaitlyn Baranowski, Alexander Brezzani, Hilde De Busser, Kelly George

J Pharmacol Exp Ther· November 2023

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Apoptotic stress causes mtDNA release during senescence and drives the SASP.
Stella Victorelli, Hanna Salmonowicz, James Chapman, Helene Martini, Maria Grazia Vizioli, George Kelly

Nature· October 2023

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Using ecosystem health and welfare assessments to determine impacts of wild collection for public aquariums.
Brittany Fischer, Jessica Pempek, Kelly Ann George, Jaylene Flint, Thomas Wittum

PLoS One· May 2023

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Transcriptomic characterization of clinical skeletal muscle biopsy from late-onset Pompe patients.
Sofia Kinton, Michael R Dufault, Mindy Zhang, Kelly George

Mol Genet Metab· March 2023

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Clinical relevance of globotriaosylceramide accumulation in Fabry disease and the effect of agalsidase beta in affected tissues.
Camilla Tøndel, Beth L Thurberg, Pronabesh DasMahapatra, Nicole Lyn, Manish Maski, Kelly George

Mol Genet Metab· December 2022

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Autophagy promotes cell survival by maintaining NAD levels.
Tetsushi Kataura, Lucia Sedlackova, Elsje G Otten, Ruchika Kumari, David Shapira, George Kelly

Dev Cell· November 2022

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Factor quinolinone inhibitors disrupt spindles and multiple LSF (TFCP2)-protein interactions in mitosis, including with microtubule-associated proteins.
Sarah A Yunes, Jennifer L S Willoughby, Julian H Kwan, Jessica M Biagi, Niranjana Pokharel, Kelly George

PLoS One· June 2022

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Short senolytic or senostatic interventions rescue progression of radiation-induced frailty and premature ageing in mice.
Edward Fielder, Tengfei Wan, Ghazaleh Alimohammadiha, Abbas Ishaq, Evon Low, George Kelly

Elife· May 2022

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Comparability of Biologics: Global Principles, Evidentiary Consistency and Unrealized Reliance.
Christopher J Webster, Kelly L George, Gillian R Woollett

BioDrugs· July 2021

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A focus group study of Ontario dairy producer perspectives on neonatal care of male and female calves.
Devon J Wilson, Jessica A Pempek, Steve M Roche, Katherine C Creutzinger, Samantha R Locke, Kelly A George

J Dairy Sci· May 2021

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Human DDK rescues stalled forks and counteracts checkpoint inhibition at unfired origins to complete DNA replication.
Mathew J K Jones, Camille Gelot, Stephanie Munk, Amnon Koren, Yoshitaka Kawasoe, Kelly A George

Mol Cell· February 2021

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Neurodegenerative Disease-Related Proteins within the Epidermal Layer of the Human Skin.
S Can Akerman, Shireen Hossain, Adeola Shobo, Yifei Zhong, Roland Jourdain, Kelly George

J Alzheimers Dis· September 2020

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Targeting the oncogene LSF with either the small molecule inhibitor FQI1 or siRNA causes mitotic delays with unaligned chromosomes, resulting in cell death or senescence.
Jennifer L S Willoughby, Kelly George, Mark P Roberto, Hang Gyeong Chin, Patrick Stoiber

BMC Cancer· June 2020

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The pROS of Autophagy in Neuronal Health.
Lucia Sedlackova, George Kelly, Viktor I Korolchuk

J Mol Biol· April 2020

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Insulins as Drugs or Biologics in the USA: What Difference Does it Make and Why Does it Matter?
Kelly George, Gillian Woollett

BioDrugs· October 2019

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Big Data Just Got Bigger: Implications of Real-World Evidence and Patient-Entered Data on Health Care and Health Care Policy.
Dana M George, Aaron E George, Kelly L George

Am J Lifestyle Med· October 2019

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Chronic UVA1 Irradiation of Human Dermal Fibroblasts: Persistence of DNA Damage and Validation of a Cell Cultured-Based Model of Photoaging.
Alicia Montoni, Kelly M George, Jérémie Soeur, Christian Tran, Laurent Marrot

J Invest Dermatol· August 2019

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