Publications by authors named "Ken Dower"

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Stricturing Crohn's Disease Single-Cell RNA Sequencing Reveals Fibroblast Heterogeneity and Intercellular Interactions.
Pranab K Mukherjee, Quang Tam Nguyen, Jiannan Li, Shuai Zhao, Stephen M Christensen, Ken Dower

Gastroenterology· November 2023

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A protein kinase C α and β inhibitor blunts hyperphagia to halt renal function decline and reduces adiposity in a rat model of obesity-driven type 2 diabetes.
Ju Wang, Agustin Casimiro-Garcia, Bryce G Johnson, Jennifer Duffen, Michael Cain, Ken Dower

Sci Rep· October 2023

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Identification of a broadly fibrogenic macrophage subset induced by type 3 inflammation.
Thomas Fabre, Alexander M S Barron, Stephen M Christensen, Shoh Asano, Kathryn Bound, Ken Dower

Sci Immunol· April 2023

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Stricturing Crohn's disease single-cell RNA sequencing reveals fibroblast heterogeneity and intercellular interactions.
Pranab K Mukherjee, Quang Tam Nguyen, Jiannan Li, Shuai Zhao, Stephen M Christensen, Ken Dower

bioRxiv· April 2023

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The Interleukin-1 Receptor-Associated Kinase 4 Inhibitor PF-06650833 Blocks Inflammation in Preclinical Models of Rheumatic Disease and in Humans Enrolled in a Randomized Clinical Trial.
Aaron Winkler, Weiyong Sun, Saurav De, Aiping Jiao, M Nusrat Sharif, Ken Dower

Arthritis Rheumatol· December 2021

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41-Week Study of Progressive Diabetic Nephropathy in the ZSF1 fa/fa Rat Model.
Bruce L Homer, Ken Dower

Toxicol Pathol· December 2018

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Computational identification and validation of alternative splicing in ZSF1 rat RNA-seq data, a preclinical model for type 2 diabetic nephropathy.
Chi Zhang, Ken Dower, Baohong Zhang, Robert V Martinez, Lih-Ling Lin

Sci Rep· May 2018

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High resolution molecular and histological analysis of renal disease progression in ZSF1 fa/faCP rats, a model of type 2 diabetic nephropathy.
Ken Dower, Shanrong Zhao, Franklin J Schlerman, Leigh Savary, Gabriela Campanholle

PLoS One· October 2017

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Discovery of PF-06928215 as a high affinity inhibitor of cGAS enabled by a novel fluorescence polarization assay.
Justin Hall, Amy Brault, Fabien Vincent, Shawn Weng, Hong Wang, Ken Dower

PLoS One· October 2017

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Discovery of Clinical Candidate 1-{[(2S,3S,4S)-3-Ethyl-4-fluoro-5-oxopyrrolidin-2-yl]methoxy}-7-methoxyisoquinoline-6-carboxamide (PF-06650833), a Potent, Selective Inhibitor of Interleukin-1 Receptor Associated Kinase 4 (IRAK4), by Fragment-Based Drug Design.
Katherine L Lee, Catherine M Ambler, David R Anderson, Brian P Boscoe, Andrea G Bree, Ken Dower

J Med Chem· July 2017

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Efficacy and Pharmacology of the NLRP3 Inflammasome Inhibitor CP-456,773 (CRID3) in Murine Models of Dermal and Pulmonary Inflammation.
Michael J Primiano, Bruce A Lefker, Michael R Bowman, Andrea G Bree, Cedric Hubeau, Ken Dower

J Immunol· September 2016

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Probing the virus host interaction in high containment: an approach using pooled short hairpin RNA.
Claire Marie Filone, Ken Dower, Glenn S Cowley, Lisa E Hensley, John H Connor

Assay Drug Dev Technol· November 2015

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Vaccinia reporter viruses for quantifying viral function at all stages of gene expression.
Daniel K Rozelle, Claire Marie Filone, Ken Dower, John H Connor

J Vis Exp· May 2014

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Interleukin 1/Toll-like receptor-induced autophosphorylation activates interleukin 1 receptor-associated kinase 4 and controls cytokine induction in a cell type-specific manner.
Leah Cushing, Wayne Stochaj, Marshall Siegel, Robert Czerwinski, Ken Dower

J Biol Chem· April 2014

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The master regulator of the cellular stress response (HSF1) is critical for orthopoxvirus infection.
Claire Marie Filone, Ignacio S Caballero, Ken Dower, Marc L Mendillo, Glenn S Cowley

PLoS Pathog· February 2014

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Myxoma and vaccinia viruses bind differentially to human leukocytes.
Winnie M Chan, Eric C Bartee, Jan S Moreb, Ken Dower, John H Connor

J Virol· April 2013

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Identification of a pyridopyrimidinone inhibitor of orthopoxviruses from a diversity-oriented synthesis library.
Ken Dower, Claire Marie Filone, Erin N Hodges, Zach B Bjornson, Kathleen H Rubins

J Virol· March 2012

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Stimulation of TLR4 by recombinant HSP70 requires structural integrity of the HSP70 protein itself.
Michael Luong, Yanyu Zhang, Tim Chamberlain, Tianhui Zhou, Jill F Wright, Ken Dower

J Inflamm (Lond)· March 2012

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Development of Vaccinia reporter viruses for rapid, high content analysis of viral function at all stages of gene expression.
Ken Dower, Kathleen H Rubins, Lisa E Hensley, John H Connor

Antiviral Res· July 2011

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TREM-1 expression is increased in the synovium of rheumatoid arthritis patients and induces the expression of pro-inflammatory cytokines.
Jun Kuai, Bernard Gregory, Andrew Hill, Debra D Pittman, Jeffrey L Feldman, Ken Dower

Rheumatology (Oxford)· November 2009

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Innate immune responses to TREM-1 activation: overlap, divergence, and positive and negative cross-talk with bacterial lipopolysaccharide.
Ken Dower, Debra K Ellis, Kathryn Saraf, Scott A Jelinsky, Lih-Ling Lin

J Immunol· March 2008

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3'-end formation signals modulate the association of genes with the nuclear periphery as well as mRNP dot formation.
Katharine C Abruzzi, Dmitry A Belostotsky, Julia A Chekanova, Ken Dower, Michael Rosbash

EMBO J· September 2006

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A synthetic A tail rescues yeast nuclear accumulation of a ribozyme-terminated transcript.
Ken Dower, Nicolas Kuperwasser, Houra Merrikh, Michael Rosbash

RNA· December 2004

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Nonsense-mediated decay does not occur within the yeast nucleus.
Nicolas Kuperwasser, Saverio Brogna, Ken Dower, Michael Rosbash

RNA· December 2004

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Early formation of mRNP: license for export or quality control?
Torben Heick Jensen, Ken Dower, Domenico Libri, Michael Rosbash

Mol Cell· May 2003

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