Publications by authors named "Ken Shimamura"

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Discovery and characterization of a novel potent, selective and orally active inhibitor for mammalian ELOVL6.
Ken Shimamura, Akira Nagumo, Yasuhisa Miyamoto, Hidefumi Kitazawa, Maki Kanesaka

Eur J Pharmacol· March 2010

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Discovery of novel benzoxazinones as potent and orally active long chain fatty acid elongase 6 inhibitors.
Takashi Mizutani, Shiho Ishikawa, Tsuyoshi Nagase, Hidekazu Takahashi, Takashi Fujimura, Ken Shimamura

J Med Chem· November 2009

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Identification and characterization of a selective radioligand for ELOVL6.
Ken Shimamura, Hidekazu Takahashi, Hidefumi Kitazawa, Yasuhisa Miyamoto, Akira Nagumo

J Biochem· September 2009

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Identification of a stable chemerin analog with potent activity toward ChemR23.
Ken Shimamura, Masao Matsuda, Yasuhisa Miyamoto, Ryo Yoshimoto, Toru Seo

Peptides· August 2009

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Development of a high-density assay for long-chain fatty acyl-CoA elongases.
Hidefumi Kitazawa, Yasuhisa Miyamoto, Ken Shimamura, Akira Nagumo, Shigeru Tokita

Lipids· August 2009

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Synthesis and evaluation of a novel 2-azabicyclo[2.2.2]octane class of long chain fatty acid elongase 6 (ELOVL6) inhibitors.
Takahide Sasaki, Tsuyoshi Nagase, Toshiyuki Takahashi, Akira Nagumo, Ken Shimamura

Bioorg Med Chem· August 2009

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5,5-Dimethyl-3-(5-methyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-1-phenyl-3-(trifluoromethyl)-3,5,6,7-tetrahydro-1H-indole-2,4-dione, a potent inhibitor for mammalian elongase of long-chain fatty acids family 6: examination of its potential utility as a pharmacological tool.
Ken Shimamura, Hidefumi Kitazawa, Yasuhisa Miyamoto, Maki Kanesaka, Akira Nagumo

J Pharmacol Exp Ther· July 2009

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Synthesis and biological evaluation of a novel 3-sulfonyl-8-azabicyclo[3.2.1]octane class of long chain fatty acid elongase 6 (ELOVL6) inhibitors.
Tsuyoshi Nagase, Toshiyuki Takahashi, Takahide Sasaki, Akira Nagumo, Ken Shimamura

J Med Chem· July 2009

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(-)-Ternatin inhibits adipogenesis and lipid metabolism in 3T3-L1 cells.
Masahiko Ito, Junko Ito, Hidefumi Kitazawa, Ken Shimamura, Takehiro Fukami

Peptides· June 2009

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Synthesis and evaluation of a novel indoledione class of long chain fatty acid elongase 6 (ELOVL6) inhibitors.
Toshiyuki Takahashi, Tsuyoshi Nagase, Takahide Sasaki, Akira Nagumo, Ken Shimamura

J Med Chem· May 2009

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High-throughput assay for long chain fatty acyl-CoA elongase using homogeneous scintillation proximity format.
Ken Shimamura, Yasuhisa Miyamoto, Hidefumi Kitazawa, Tsutomu Kobayashi, Hidehito Kotani

Assay Drug Dev Technol· April 2009

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Therapeutic potential of histamine H3 receptor agonist for the treatment of obesity and diabetes mellitus.
Ryo Yoshimoto, Yasuhisa Miyamoto, Ken Shimamura, Akane Ishihara, Kazuhiko Takahashi

Proc Natl Acad Sci U S A· September 2006

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Expression of adhesion molecules by sphingosine 1-phosphate and histamine in endothelial cells.
Ken Shimamura, Yuko Takashiro, Nobuteru Akiyama, Tetsuya Hirabayashi, Toshihiko Murayama

Eur J Pharmacol· February 2004

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Mesaconitine-induced relaxation in rat aorta: role of Na+/Ca2+ exchangers in endothelial cells.
Junko Ogura, Mana Mitamura, Akiyoshi Someya, Ken Shimamura, Hiromitsu Takayama

Eur J Pharmacol· January 2004

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