Publications by authors named "Kenneth Broadley"

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Reappraisal of the mechanism of cardiovascular responses to sympathomimetic amines in anaesthetised rats: dual α-adrenoceptor and trace amine receptor mechanisms.
Kenneth J Broadley

Naunyn Schmiedebergs Arch Pharmacol· March 2025

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Is there a role for biogenic amine receptors in mediating β-phenylethylamine and RO5256390-induced vascular contraction?
Alexander C Voisey, Harrison D Broadley, Kenneth J Broadley, William R Ford

Eur J Pharmacol· October 2024

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Trace amine-induced vasoconstriction of human mammary artery and saphenous vein.
Kenneth J Broadley, Dheeraj Mehta

Vascul Pharmacol· August 2023

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Characterization of Negative Allosteric Modulators of the Calcium-Sensing Receptor for Repurposing as a Treatment of Asthma.
Polina L Yarova, Ping Huang, Martin W Schepelmann, Richard Bruce, Rupert Ecker, Kenneth J Broadley

J Pharmacol Exp Ther· January 2021

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Modulation of vascular responses of guinea-pig aorta by non-endothelial nitric oxide: A minor role for the endothelium.
Kenneth J Broadley, Harrison D Broadley

Vascul Pharmacol· October 2019

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Non-adrenergic vasoconstriction and vasodilatation of guinea-pig aorta by β-phenylethylamine and amphetamine - Role of nitric oxide determined with L-NAME and NO scavengers.
Kenneth J Broadley, Harrison D Broadley

Eur J Pharmacol· January 2018

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Death Receptor 3 regulates distinct pathological attributes of acute versus chronic murine allergic lung inflammation.
Ravinder Kaur Singh, William Victor Perks, Jason Peter Twohig, Emma J Kidd, Kenneth Broadley

Cell Immunol· October 2017

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Route of Administration Affects Corticosteroid Sensitivity of a Combined Ovalbumin and Lipopolysaccharide Model of Asthma Exacerbation in Guinea Pigs.
Alexander P P Lowe, Rhian S Thomas, Anthony T Nials, Emma J Kidd, Kenneth J Broadley

J Pharmacol Exp Ther· August 2017

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Effects of nebulised magnesium sulphate on inflammation and function of the guinea-pig airway.
Dawn L Turner, William R Ford, Emma J Kidd, Kenneth J Broadley, Colin Powell

Eur J Pharmacol· April 2017

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The synthesis of a series of adenosine A3 receptor agonists.
Kenneth J Broadley, Erica Burnell, Robin H Davies, Alan T L Lee, Stephen Snee

Org Biomol Chem· April 2016

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Stereoselective synthesis of oxazolidinonyl-fused piperidines of interest as selective muscarinic (M1) receptor agonists: a novel M1 allosteric modulator.
Kenneth J Broadley, Maxime G P Buffat, Erica Burnell, Robin H Davies, Xavier Moreau

Org Biomol Chem· February 2016

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Adjustment of sensitisation and challenge protocols restores functional and inflammatory responses to ovalbumin in guinea-pigs.
Alexander P P Lowe, Kenneth J Broadley, Anthony T Nials, William R Ford, Emma J Kidd

J Pharmacol Toxicol Methods· December 2015

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Pulmonary edema measured by MRI correlates with late-phase response to allergen challenge.
Rhys L Evans, Kumar K Changani, Sarah Hotee, Kashmira Pindoria, Simon Campbell, Kenneth J Broadley

Exp Lung Res· May 2015

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Calcium-sensing receptor antagonists abrogate airway hyperresponsiveness and inflammation in allergic asthma.
Polina L Yarova, Alecia L Stewart, Venkatachalem Sathish, Rodney D Britt, Michael A Thompson, Kenneth J Broadley

Sci Transl Med· April 2015

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Human parainfluenza type 3 virus impairs the efficacy of glucocorticoids to limit allergy-induced pulmonary inflammation in guinea-pigs.
William R Ford, Alan E Blair, Rhys L Evans, Elinor John, Joachim J Bugert, Kenneth J Broadley

Clin Sci (Lond)· November 2013

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Functional evaluation of the receptors mediating vasoconstriction of rat aorta by trace amines and amphetamines.
Kenneth J Broadley, Martina Fehler, William R Ford, Emma J Kidd

Eur J Pharmacol· September 2013

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Signal transduction and modulating pathways in tryptamine-evoked vasopressor responses of the rat isolated perfused mesenteric bed.
M Akhtar Anwar, William R Ford, Amy A Herbert, Kenneth J Broadley

Vascul Pharmacol· January 2013

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A comparison of antiasthma drugs between acute and chronic ovalbumin-challenged guinea-pig models of asthma.
Rhys L Evans, Anthony T Nials, Richard G Knowles, Emma J Kidd, William R Ford, Kenneth J Broadley

Pulm Pharmacol Ther· December 2012

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Inhaled extended-release microparticles of heparin elicit improved pulmonary pharmacodynamics against antigen-mediated airway hyper-reactivity and inflammation.
Ayca Yildiz, Elinor John, Yildiz Özsoy, Ahmet Araman, James C Birchall, Kenneth J Broadley

J Control Release· September 2012

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Actions of Artemisia vulgaris extracts and isolated sesquiterpene lactones against receptors mediating contraction of guinea pig ileum and trachea.
Gaudencio M Natividad, Kenneth J Broadley, Benson Kariuki, Emma J Kidd, William R Ford

J Ethnopharmacol· September 2011

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Paracetamol reduces influenza-induced immunopathology in a mouse model of infection without compromising virus clearance or the generation of protective immunity.
Sarah N Lauder, Philip R Taylor, Stephen R Clark, Rhys L Evans, James P Hindley, Kenneth J Broadley

Thorax· May 2011

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Bradykinin-induced lung inflammation and bronchoconstriction: role in parainfluenze-3 virus-induced inflammation and airway hyperreactivity.
Kenneth J Broadley, Alan E Blair, Emma J Kidd, Joachim J Bugert, William R Ford

J Pharmacol Exp Ther· December 2010

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Towards a thermodynamic definition of efficacy in partial agonism: The thermodynamics of efficacy and ligand proton transfer in a G protein-coupled receptor of the rhodopsin class.
Kenneth J Broadley, Shane C Sykes, Robin H Davies

Biochem Pharmacol· November 2010

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Identification of trace-amine-associated receptors (TAAR) in the rat aorta and their role in vasoconstriction by β-phenylethylamine.
Martina Fehler, Kenneth J Broadley, William R Ford, Emma J Kidd

Naunyn Schmiedebergs Arch Pharmacol· October 2010

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TPI 1020, a novel anti-inflammatory, nitric oxide donating compound, potentiates the bronchodilator effects of salbutamol in conscious guinea-pigs.
Dawn L Turner, Nicolay Ferrari, William R Ford, Emma J Kidd, Luc Paquet, Kenneth J Broadley

Eur J Pharmacol· September 2010

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