Publications by authors named "Kenneth D Setchell"

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Patient-Specific Midbrain Organoids with CRISPR Correction Reveal Disease Mechanisms and Enable Therapeutic Evaluation in Neuronopathic Gaucher Disease.
Yi Lin, Benjamin Liou, Venette Fannin, Stuart Adler, Christopher N Mayhew, Kenneth Dr Setchell

bioRxiv· November 2025

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Microbial metabolite drives ageing-related clonal haematopoiesis via ALPK1.
Puneet Agarwal, Avery Sampson, Kathleen Hueneman, Kwangmin Choi, Niels Asger Jakobsen, Kenneth D Setchell

Nature· June 2025

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Perspective: Isoflavones-Intriguing Molecules but Much Remains to Be Learned about These Soybean Constituents.
Mark Messina, Stephen Barnes, Kenneth Dr Setchell

Adv Nutr· May 2025

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Inhibition of RHOA activity preserves the survival and hemostasis function of long-term cold-stored platelets.
Shailaja Hegde, Huzoor Akbar, Ashley M Wellendorf, Shawnagay Nestheide, James F Johnson, Kenneth D Setchell

Blood· October 2024

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Assessment of the role of FGF15 in mediating the metabolic outcomes of murine Vertical Sleeve Gastrectomy (VSG).
Andriy Myronovych, Jashdeep Bhattacharjee, Rosa-Maria Salazar-Gonzalez, Brandon Tan, Sarah Mowery, Kenneth Dr Setchell

Am J Physiol Gastrointest Liver Physiol· September 2020

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Unraveling the Relationship Between Itching, Scratch Scales, and Biomarkers in Children With Alagille Syndrome.
Binita M Kamath, Cathie Spino, Richard McLain, John C Magee, Emily M Fredericks, Kenneth D Setchell

Hepatol Commun· July 2020

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Disarranged Sphingolipid Metabolism From Sphingosine-1-Phosphate Lyase Deficiency Leads to Congenital Nephrotic Syndrome.
Veronica A Taylor, Hillarey K Stone, Meredith P Schuh, Xueheng Zhao, Kenneth D Setchell

Kidney Int Rep· December 2019

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The FOXM1 Inhibitor RCM-1 Decreases Carcinogenesis and Nuclear β-Catenin.
Samriddhi Shukla, David Milewski, Arun Pradhan, Nihar Rama, Kathryn Rice, Kenneth D Setchell

Mol Cancer Ther· July 2019

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Serum Unconjugated Bile Acids and Small Bowel Bacterial Overgrowth in Pediatric Intestinal Failure: A Pilot Study.
David Galloway, Ethan Mezoff, Wujuan Zhang, Melissa Byrd, Conrad Cole, Kenneth Dr Setchell

JPEN J Parenter Enteral Nutr· February 2019

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Δ4-3-oxosteroid-5β-reductase deficiency: Responses to oral bile acid therapy and long-term outcomes.
Mei-Hong Zhang, Kenneth Dr Setchell, Jing Zhao, Jing-Yu Gong, Yi Lu

World J Gastroenterol· February 2019

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Placebo-Controlled Randomized Trial of an Intestinal Bile Salt Transport Inhibitor for Pruritus in Alagille Syndrome.
Benjamin L Shneider, Cathie Spino, Binita M Kamath, John C Magee, Lee M Bass, Kenneth D Setchell

Hepatol Commun· October 2018

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Infant cholestasis patient with a novel missense mutation in the gene successfully treated by early adequate supplementation with chenodeoxycholic acid: A case report and review of the literature.
Hui-Hui Wang, Fei-Qiu Wen, Dong-Ling Dai, Jian-She Wang, Jing Zhao, Kenneth Dr Setchell

World J Gastroenterol· September 2018

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Complement drives glucosylceramide accumulation and tissue inflammation in Gaucher disease.
Manoj K Pandey, Thomas A Burrow, Reena Rani, Lisa J Martin, David Witte, Kenneth D Setchell

Nature· March 2017

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Combination Therapy of All-Trans Retinoic Acid With Ursodeoxycholic Acid in Patients With Primary Sclerosing Cholangitis: A Human Pilot Study.
David N Assis, Osama Abdelghany, Shi-Ying Cai, Andrea A Gossard, John E Eaton, Kenneth D R Setchell

J Clin Gastroenterol· February 2017

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Modulating ryanodine receptors with dantrolene attenuates neuronopathic phenotype in Gaucher disease mice.
Benjamin Liou, Yanyan Peng, Ronghua Li, Venette Inskeep, Wujuan Zhang, Kenneth D R Setchell

Hum Mol Genet· December 2016

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Stable-Isotope Dilution HPLC-Electrospray Ionization Tandem Mass Spectrometry Method for Quantifying Hydroxyurea in Dried Blood Samples.
Anu Marahatta, Vandana Megaraj, Patrick T McGann, Russell E Ware, Kenneth D R Setchell

Clin Chem· December 2016

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Fibroblast growth factor 21 correlates with weight loss after vertical sleeve gastrectomy in adolescents.
Farooq H Khan, Lindsey Shaw, Wujuan Zhang, Rosa Maria Salazar Gonzalez, Sarah Mowery, Kenneth D R Setchell

Obesity (Silver Spring)· November 2016

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Inhibition of ileal bile acid uptake protects against nonalcoholic fatty liver disease in high-fat diet-fed mice.
Anuradha Rao, Astrid Kosters, Jamie E Mells, Wujuan Zhang, Kenneth D R Setchell

Sci Transl Med· September 2016

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Cognitive Effects of Soy Isoflavones in Patients with Alzheimer's Disease.
Carey E Gleason, Barbara L Fischer, N Maritza Dowling, Kenneth D R Setchell, Craig S Atwood

J Alzheimers Dis· July 2016

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Bile Acid Signaling: Mechanism for Bariatric Surgery, Cure for NASH?
Rohit Kohli, Andriy Myronovych, Brandon K Tan, Rosa-Maria Salazar-Gonzalez, Lili Miles, Kenneth D R Setchell

Dig Dis· March 2016

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Pharmacological inhibition of apical sodium-dependent bile acid transporter changes bile composition and blocks progression of sclerosing cholangitis in multidrug resistance 2 knockout mice.
Alexander G Miethke, Wujuan Zhang, Julia Simmons, Amy E Taylor, Tiffany Shi, Kenneth D R Setchell

Hepatology· February 2016

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Let the bile flow!
Rohit Kohli, Kenneth D R Setchell

Hepatology· December 2015

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Neuronopathic Gaucher disease: dysregulated mRNAs and miRNAs in brain pathogenesis and effects of pharmacologic chaperone treatment in a mouse model.
Nupur Dasgupta, You-Hai Xu, Ronghua Li, Yanyan Peng, Manoj K Pandey, Kenneth D R Setchell

Hum Mol Genet· December 2015

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Differential Requirements for L-Citrulline and L-Arginine during Antimycobacterial Macrophage Activity.
Shannon M Rapovy, Junfang Zhao, Rebecca L Bricker, Stephanie M Schmidt, Kenneth D R Setchell

J Immunol· October 2015

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Tandem mass spectrometric determination of atypical 3β-hydroxy-Δ5-bile acids in patients with 3β-hydroxy-Δ5-C27-steroid oxidoreductase deficiency: application to diagnosis and monitoring of bile acid therapeutic response.
Wujuan Zhang, Pinky Jha, Brian Wolfe, Antimo Gioiello, Roberto Pellicciari, Kenneth D R Setchell

Clin Chem· July 2015

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