Publications by authors named "Kenneth J Linton"

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Structural basis for the modulation of MRP2 activity by phosphorylation and drugs.
Tiziano Mazza, Theodoros I Roumeliotis, Elena Garitta, David Drew, S Tamir Rashid, Kenneth J Linton

Nat Commun· March 2024

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Molecular Modeling Studies to Probe the Binding Hypothesis of Novel Lead Compounds against Multidrug Resistance Protein ABCB1.
Yasmeen Cheema, Kenneth J Linton, Ishrat Jabeen

Biomolecules· January 2024

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Rare variant contribution to cholestatic liver disease in a South Asian population in the United Kingdom.
Julia Zöllner, Sarah Finer, Kenneth J Linton, , David A van Heel

Sci Rep· May 2023

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Identification and Empiric Evaluation of New Inhibitors of the Multidrug Transporter P-Glycoprotein (ABCB1).
Yasmeen Cheema, Yusra Sajid Kiani, Kenneth J Linton, Ishrat Jabeen

Int J Mol Sci· March 2023

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ABCB1 Does Not Require the Side-Chain Hydrogen-Bond Donors Gln, Gln, Gln to Confer Cellular Resistance to the Anticancer Drug Taxol.
Keerthana Sasitharan, Hamzah Asad Iqbal, Foteini Bifsa, Aleksandra Olszewska, Kenneth J Linton

Int J Mol Sci· August 2021

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Inhibition of the Lysophosphatidylinositol Transporter ABCC1 Reduces Prostate Cancer Cell Growth and Sensitizes to Chemotherapy.
Aikaterini Emmanouilidi, Ilaria Casari, Begum Gokcen Akkaya, Tania Maffucci, Luc Furic, Kenneth J Linton

Cancers (Basel)· July 2020

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Contribution of rare coding mutations in CD36 to type 2 diabetes and cardio-metabolic complications.
David Meyre, Edward J Andress, Tanmay Sharma, Marjolein Snippe, Hamza Asif, Kenneth J Linton

Sci Rep· November 2019

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ABCC3 is a novel target for the treatment of pancreatic cancer.
Aleksandra Adamska, Riccardo Ferro, Rossano Lattanzio, Emily Capone, Alice Domenichini, Kenneth J Linton

Adv Biol Regul· August 2019

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Pharmacological inhibition of ABCC3 slows tumour progression in animal models of pancreatic cancer.
Aleksandra Adamska, Alice Domenichini, Emily Capone, Verena Damiani, Begum Gokcen Akkaya, Kenneth J Linton

J Exp Clin Cancer Res· August 2019

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Identification of CD36 as a new interaction partner of membrane NEU1: potential implication in the pro-atherogenic effects of the elastin receptor complex.
Charlotte Kawecki, Olivier Bocquet, Christian E H Schmelzer, Andrea Heinz, Christian Ihling, Kenneth J Linton

Cell Mol Life Sci· February 2019

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A Novel Mechanism for Activation of GLI1 by Nuclear SMO That Escapes Anti-SMO Inhibitors.
Muhammad M Rahman, Allon Hazan, Joanne L Selway, Dimalee S Herath, Catherine A Harwood, Kenneth J Linton

Cancer Res· May 2018

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ABCB4 missense mutations D243A, K435T, G535D, I490T, R545C, and S978P significantly impair the lipid floppase and likely predispose to secondary pathologies in the human population.
Edward J Andress, Michael Nicolaou, Farrell McGeoghan, Kenneth J Linton

Cell Mol Life Sci· July 2017

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The multidrug resistance pump ABCB1 is a substrate for the ubiquitin ligase NEDD4-1.
Begum G Akkaya, Joseph K Zolnerciks, Tasha K Ritchie, Bjoern Bauer, Anika M S Hartz, Kenneth J Linton

Mol Membr Biol· May 2016

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Lipid flopping in the liver.
Kenneth J Linton

Biochem Soc Trans· October 2015

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The Q loops of the human multidrug resistance transporter ABCB1 are necessary to couple drug binding to the ATP catalytic cycle.
Joseph K Zolnerciks, Begum G Akkaya, Marjolein Snippe, Peter Chiba, Anna Seelig, Kenneth J Linton

FASEB J· October 2014

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Molecular mechanistic explanation for the spectrum of cholestatic disease caused by the S320F variant of ABCB4.
Edward J Andress, Michael Nicolaou, Marta R Romero, Sandhia Naik, Peter H Dixon, Kenneth J Linton

Hepatology· May 2014

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Inactive alleles of cytochrome P450 2C19 may be positively selected in human evolution.
Ramatoulie E Janha, Archibald Worwui, Kenneth J Linton, Seif O Shaheen, Fatoumatta Sisay-Joof

BMC Evol Biol· April 2014

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Mutations in AQP5, encoding a water-channel protein, cause autosomal-dominant diffuse nonepidermolytic palmoplantar keratoderma.
Diana C Blaydon, Lisbet K Lind, Vincent Plagnol, Kenneth J Linton, Francis J D Smith

Am J Hum Genet· August 2013

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Investigational ABC transporter inhibitors.
Marco Falasca, Kenneth J Linton

Expert Opin Investig Drugs· May 2012

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Canalicular ABC transporters and liver disease.
Michael Nicolaou, Edward J Andress, Joseph K Zolnerciks, Peter H Dixon, Catherine Williamson, Kenneth J Linton

J Pathol· January 2012

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Complementary functions of the flippase ATP8B1 and the floppase ABCB4 in maintaining canalicular membrane integrity.
Annemiek Groen, Marta Rodriguez Romero, Cindy Kunne, Sarah J Hoosdally, Peter H Dixon, Kenneth J Linton

Gastroenterology· November 2011

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Structure of ABC transporters.
Joseph K Zolnerciks, Edward J Andress, Michael Nicolaou, Kenneth J Linton

Essays Biochem· September 2011

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The Human Scavenger Receptor CD36: glycosylation status and its role in trafficking and function.
Sarah J Hoosdally, Edward J Andress, Carol Wooding, Catherine A Martin, Kenneth J Linton

J Biol Chem· June 2009

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Missense mutations and single nucleotide polymorphisms in ABCB11 impair bile salt export pump processing and function or disrupt pre-messenger RNA splicing.
Jane A Byrne, Sandra S Strautnieks, Gudrun Ihrke, Franco Pagani, A S Knisely, Kenneth J Linton

Hepatology· February 2009

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Cd36, a class B scavenger receptor, functions as a monomer to bind acetylated and oxidized low-density lipoproteins.
Catherine A Martin, Emma Longman, Carol Wooding, Sarah J Hoosdally, Saira Ali, Kenneth J Linton

Protein Sci· November 2007

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