Publications by authors named "Kentaro Sakaniwa"

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The structures of the peptide transporters SLC15A3 and SLC15A4 reveal the recognition mechanisms for substrate and TASL.
Zhikuan Zhang, Shota Kasai, Kentaro Sakaniwa, Akiko Fujimura, Umeharu Ohto

Structure· February 2025

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A novel Toll-like receptor 7/8-specific antagonist E6742 ameliorates clinically relevant disease parameters in murine models of lupus.
Sally T Ishizaka, Lynn Hawkins, Qian Chen, Fumitoshi Tago, Takuya Yagi, Kentaro Sakaniwa

Eur J Pharmacol· October 2023

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TLR3 forms a laterally aligned multimeric complex along double-stranded RNA for efficient signal transduction.
Kentaro Sakaniwa, Akiko Fujimura, Takuma Shibata, Hideki Shigematsu, Toru Ekimoto

Nat Commun· January 2023

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Tetrasubstituted imidazoles as incognito Toll-like receptor 8 a(nta)gonists.
Yi Yang, Adam Csakai, Shuangshuang Jiang, Christina Smith, Hiromi Tanji, Kentaro Sakaniwa

Nat Commun· July 2021

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Targeting the innate immune receptor TLR8 using small-molecule agents. Corrigendum.
Kentaro Sakaniwa, Toshiyuki Shimizu

Acta Crystallogr D Struct Biol· September 2020

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Targeting the innate immune receptor TLR8 using small-molecule agents.
Kentaro Sakaniwa, Toshiyuki Shimizu

Acta Crystallogr D Struct Biol· July 2020

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Rationally Designed Small-Molecule Inhibitors Targeting an Unconventional Pocket on the TLR8 Protein-Protein Interface.
Shuangshuang Jiang, Hiromi Tanji, Kejun Yin, Shuting Zhang, Kentaro Sakaniwa

J Med Chem· April 2020

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Discovery of Novel Small Molecule Dual Inhibitors Targeting Toll-Like Receptors and .
Rosaura Padilla-Salinas, Rachel Anderson, Kentaro Sakaniwa, Shuting Zhang, Patrick Nordeen

J Med Chem· November 2019

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Small-Molecule TLR8 Antagonists via Structure-Based Rational Design.
Zhenyi Hu, Hiromi Tanji, Shuangshuang Jiang, Shuting Zhang, Kyoin Koo, Kentaro Sakaniwa

Cell Chem Biol· October 2018

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Small-molecule inhibition of TLR8 through stabilization of its resting state.
Shuting Zhang, Zhenyi Hu, Hiromi Tanji, Shuangshuang Jiang, Nabanita Das, Kentaro Sakaniwa

Nat Chem Biol· January 2018

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