Publications by authors named "Kequan Fu"

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Targeting TRAF6 inhibits cystogenesis in autosomal dominant polycystic kidney disease.
Ying Ren, Yaoyao Pan, Xiaodan Zhu, Lingyi Li, Wenchao Zhao, Kequan Fu

Biochem Pharmacol· December 2025

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Discovery of Non-benzoazacyclic VR Antagonists for the Treatment of Autosomal Dominant Polycystic Kidney Disease.
Haiyang Zhong, Zhengshuo Zhang, Mengdan Chen, Xuchao Liu, Yixiao Zhang, Kequan Fu

J Med Chem· December 2025

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Structural basis of tolvaptan binding to the vasopressin V receptor.
Hong-Li Liu, Hai-Yang Zhong, Yi-Xiao Zhang, Hua-Rui Xue, Zheng-Shuo Zhang, Ke-Quan Fu

Acta Pharmacol Sin· November 2024

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Notch3 as a novel therapeutic target for the treatment of ADPKD by regulating cell proliferation and renal cyst development.
Limin Su, Ting Chen, Hongtao Hu, Zifan Xu, Xiande Luan, Kequan Fu

Biochem Pharmacol· June 2024

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Long-Residence Time Peptide Antagonist for the Vasopressin V Receptor to Treat Autosomal Dominant Polycystic Kidney Disease.
Xiaochun Xiong, Naiyuan Wang, Yixiao Zhang, Wenchao Zhao, Ningning Pang, Kequan Fu

J Med Chem· April 2024

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A Novel Bifunctional μOR Agonist and σR Antagonist with Potent Analgesic Responses and Reduced Adverse Effects.
Zhuang Miao, Yuhan Zhong, Yu Gan, Kequan Fu, Wencheng Liu

J Med Chem· December 2023

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An allosteric modulator of the adenosine A receptor potentiates the antilipolytic effect in rat adipose tissue.
Kequan Fu, Wenbing Chen, Mingzhu Meng, Huimin Zhao, Haoxing Yuan

Eur J Pharmacol· July 2023

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Structure-Affinity and Structure-Kinetic Relationship Studies of Benzodiazepine Derivatives for the Development of Efficacious Vasopressin V Receptor Antagonists.
Xudong Cao, Peng Wang, Wenchao Zhao, Haoxing Yuan, Hongtao Hu, Kequan Fu

J Med Chem· March 2023

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2,6-diazaspiro[3.4]octan-7-one derivatives as potent sigma-1 receptor antagonists that enhanced the antinociceptive effect of morphine and rescued morphine tolerance.
Kequan Fu, Wen Xu, Ruicong Yang, Huimin Zhao, Huanyu Xu

Eur J Med Chem· March 2023

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Inhibition of deubiquitinase USP28 attenuates cyst growth in autosomal dominant polycystic kidney disease.
Ying Ren, Xiaodan Zhu, Kequan Fu, Haoran Zhang, Wenchao Zhao

Biochem Pharmacol· January 2023

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PF-06409577 inhibits renal cyst progression by concurrently inhibiting the mTOR pathway and CFTR channel activity.
Limin Su, Haoxing Yuan, Haoran Zhang, Ruoqi Wang, Kequan Fu

FEBS Open Bio· October 2022

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Benzodiazepine Derivatives as Potent Vasopressin V Receptor Antagonists for the Treatment of Autosomal Dominant Kidney Disease.
Xudong Cao, Peng Wang, Haoxing Yuan, Haoran Zhang, Yan He, Kequan Fu

J Med Chem· July 2022

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Long Residence Time at the Vasopressin V Receptor Translates into Superior Inhibitory Effects in and Models of Autosomal Dominant Polycystic Kidney Disease.
Haoran Zhang, Wenzhong Yan, Yongzhan Sun, Haoxing Yuan, Limin Su, Kequan Fu

J Med Chem· June 2022

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Schizophrenia-Like Behavioral Impairments in Mice with Suppressed Expression of Piccolo in the Medial Prefrontal Cortex.
Atsumi Nitta, Naotaka Izuo, Kohei Hamatani, Ryo Inagaki, Yuka Kusui, Kequan Fu

J Pers Med· June 2021

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Revisit ligand-receptor interaction at the human vasopressin V receptor: A kinetic perspective.
Chunji Liu, Leyi Xia, Kequan Fu, Xudong Cao, Wenzhong Yan

Eur J Pharmacol· August 2020

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Striatal N-Acetylaspartate Synthetase Shati/Nat8l Regulates Depression-Like Behaviors via mGluR3-Mediated Serotonergic Suppression in Mice.
Yoshiaki Miyamoto, Noriyuki Iegaki, Kequan Fu, Yudai Ishikawa, Kazuyuki Sumi

Int J Neuropsychopharmacol· December 2017

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Overexpression of transmembrane protein 168 in the mouse nucleus accumbens induces anxiety and sensorimotor gating deficit.
Kequan Fu, Yoshiaki Miyamoto, Kazuyuki Sumi, Eriko Saika, Shin-Ichi Muramatsu

PLoS One· December 2017

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Involvement of the accumbal osteopontin-interacting transmembrane protein 168 in methamphetamine-induced place preference and hyperlocomotion in mice.
Kequan Fu, Yoshiaki Miyamoto, Kazuya Otake, Kazuyuki Sumi, Eriko Saika

Sci Rep· October 2017

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Pseudoginsenoside-F11 inhibits methamphetamine-induced behaviors by regulating dopaminergic and GABAergic neurons in the nucleus accumbens.
Kequan Fu, Huiyang Lin, Yoshiaki Miyamoto, Chunfu Wu, Jingyu Yang

Psychopharmacology (Berl)· March 2016

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Overexpression of Shati/Nat8l, an N-acetyltransferase, in the nucleus accumbens attenuates the response to methamphetamine via activation of group II mGluRs in mice.
Yoshiaki Miyamoto, Yudai Ishikawa, Noriyuki Iegaki, Kazuyuki Sumi, Kequan Fu, Yoko Furukawa-Hibi

Int J Neuropsychopharmacol· August 2014

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