Publications by authors named "Kerry C Ryan"

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Presenilin mutations disrupt iron homeostasis to promote ferroptosis mediated neurodegeneration in Caenorhabditis elegans.
Kerry C Ryan, Jocelyn T Laboy, Rabia Ashraf, Zahra Ashkavand, Isabel Jayasinghe

Redox Biol· December 2025

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Identification of presenilin mutations that have sufficient gamma-secretase proteolytic activity to mediate Notch signaling but disrupt organelle and neuronal health.
Zahra Ashkavand, Kerry C Ryan, Jocelyn T Laboy, Ritika Patel, Brian Geller

Neurobiol Dis· August 2025

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C. elegans Presenilin Mediates Inter-Organelle Contacts and Communication that Is Required for Lysosome Activity.
Kerry C Ryan, Zahra Ashkavand, Jocelyn T Laboy, Ling Wang, Margarida Barroso

Aging Dis· February 2024

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Deregulation of Mitochondrial Calcium Handling Due to Presenilin Loss Disrupts Redox Homeostasis and Promotes Neuronal Dysfunction.
Kerry C Ryan, Jocelyn T Laboy, Kenneth R Norman

Antioxidants (Basel)· August 2022

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Increased mitochondrial calcium uptake and concomitant mitochondrial activity by presenilin loss promotes mTORC1 signaling to drive neurodegeneration.
Kerry C Ryan, Zahra Ashkavand, Shaarika Sarasija, Jocelyn T Laboy, Rohan Samarakoon

Aging Cell· October 2021

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The Role of Mitochondrial Calcium Homeostasis in Alzheimer's and Related Diseases.
Kerry C Ryan, Zahra Ashkavand, Kenneth R Norman

Int J Mol Sci· December 2020

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Corrupted ER-mitochondrial calcium homeostasis promotes the collapse of proteostasis.
Zahra Ashkavand, Shaarika Sarasija, Kerry C Ryan, Jocelyn T Laboy, Kenneth R Norman

Aging Cell· January 2020

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