Publications by authors named "Kevin Alton"

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Intestinal lymphatic transport for drug delivery.
Jaime A Yáñez, Stephen W J Wang, Ian W Knemeyer, Mark A Wirth, Kevin B Alton

Adv Drug Deliv Rev· September 2011

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Metabolomics analysis reveals elevation of 3-indoxyl sulfate in plasma and brain during chemically-induced acute kidney injury in mice: investigation of nicotinic acid receptor agonists.
Joanna R Zgoda-Pols, Swapan Chowdhury, Mark Wirth, Michael V Milburn, Danny C Alexander, Kevin B Alton

Toxicol Appl Pharmacol· August 2011

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Characterization of human liver enzymes involved in the biotransformation of boceprevir, a hepatitis C virus protease inhibitor.
Anima Ghosal, Yuan Yuan, Wei Tong, Ai-Duen Su, Chunyan Gu, Kevin B Alton

Drug Metab Dispos· March 2011

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Identification of human liver cytochrome P450 enzymes involved in the metabolism of SCH 530348 (Vorapaxar), a potent oral thrombin protease-activated receptor 1 antagonist.
Anima Ghosal, Xiaowen Lu, Natalia Penner, Lan Gao, Ragu Ramanathan, Kevin B Alton

Drug Metab Dispos· January 2011

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Quantitation of parent drug and its unstable metabolites by in situ coulometric oxidation and liquid chromatography-tandem mass spectrometry.
Wei Tong, Swapan K Chowdhury, Ai-Duen Su, Kevin B Alton

Anal Chem· December 2010

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Identification of two novel metabolites of SCH 486757, a nociceptin/orphanin FQ peptide receptor agonist, in humans.
Natalia A Penner, Ginny Ho, Ana Bercovici, Swapan K Chowdhury, Kevin B Alton

Drug Metab Dispos· November 2010

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Metabolism of loratadine and further characterization of its in vitro metabolites.
Anima Ghosal, Samir Gupta, Ragu Ramanathan, Yuan Yuan, Xiaowen Lu, Kevin B Alton

Drug Metab Lett· August 2009

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An accurate-mass-based spectral-averaging isotope-pattern-filtering algorithm for extraction of drug metabolites possessing a distinct isotope pattern from LC-MS data.
Peijuan Zhu, Wei Tong, Kevin Alton, Swapan Chowdhury

Anal Chem· July 2009

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A retention-time-shift-tolerant background subtraction and noise reduction algorithm (BgS-NoRA) for extraction of drug metabolites in liquid chromatography/mass spectrometry data from biological matrices.
Peijuan Zhu, Wei Ding, Wei Tong, Anima Ghosal, Kevin Alton

Rapid Commun Mass Spectrom· June 2009

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Identification of human liver cytochrome P450 enzymes involved in biotransformation of vicriviroc, a CCR5 receptor antagonist.
Anima Ghosal, Ragu Ramanathan, Yuan Yuan, Neil Hapangama, Swapan K Chowdhury, Kevin B Alton

Drug Metab Dispos· December 2007

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Response normalized liquid chromatography nanospray ionization mass spectrometry.
Ragu Ramanathan, Ruyun Zhong, Neil Blumenkrantz, Swapan K Chowdhury, Kevin B Alton

J Am Soc Mass Spectrom· October 2007

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Metabolism-based identification of a potent thrombin receptor antagonist.
Martin C Clasby, Samuel Chackalamannil, Michael Czarniecki, Dario Doller, Keith Eagen, Kevin Alton

J Med Chem· January 2007

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Identification of unstable metabolites of Lonafarnib using liquid chromatography-quadrupole time-of-flight mass spectrometry, stable isotope incorporation and ion source temperature alteration.
Wei Tong, Swapan K Chowdhury, Ai-Duen Su, Wenqing Feng, Anima Ghosal, Kevin B Alton

J Mass Spectrom· November 2006

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Application of mass spectrometry for metabolite identification.
Shuguang Ma, Swapan K Chowdhury, Kevin B Alton

Curr Drug Metab· June 2006

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Ezetimibe: a review of its metabolism, pharmacokinetics and drug interactions.
Teddy Kosoglou, Paul Statkevich, Amy O Johnson-Levonas, John F Paolini, Arthur J Bergman, Kevin B Alton

Clin Pharmacokinet· August 2005

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Thermally induced N-to-O rearrangement of tert-N-oxides in atmospheric pressure chemical ionization and atmospheric pressure photoionization mass spectrometry: differentiation of N-oxidation from hydroxylation and potential determination of N-oxidation site.
Shuguang Ma, Swapan K Chowdhury, Kevin B Alton

Anal Chem· June 2005

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Identification of human UDP-glucuronosyltransferase enzyme(s) responsible for the glucuronidation of 3-hydroxydesloratadine.
Anima Ghosal, Yuan Yuan, Neil Hapangama, Ai Duen Iris Su, Narciso Alvarez, Kevin B Alton

Biopharm Drug Dispos· September 2004

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Identification of human UDP-glucuronosyltransferase enzyme(s) responsible for the glucuronidation of ezetimibe (Zetia).
Anima Ghosal, Neil Hapangama, Yuan Yuan, Joana Achanfuo-Yeboah, Robert Iannucci, Kevin Alton

Drug Metab Dispos· March 2004

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Identification of human UDP-glucuronosyltransferase enzyme(s) responsible for the glucuronidation of posaconazole (Noxafil).
Anima Ghosal, Neil Hapangama, Yuan Yuan, Joana Achanfuo-Yeboah, Robert Iannucci, Kevin Alton

Drug Metab Dispos· February 2004

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Assessment of temporal biochemical and gene transcription changes in rat liver cytochrome P450: utility of real-time quantitative RT-PCR.
Federico M Goodsaid, Jairam R Palamanda, Diana Montgomery, George Mandakas, Chunyan Gu, Kevin Alton

Pharm Res· September 2003

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High-performance liquid chromatographic method for the quantification of unbound evernimicin in human plasma ultrafiltrate.
Ruyun Zhong, Abraham Hernandez, Kevin B Alton, Narendra S Kishnani, James E Patrick

J Chromatogr B Analyt Technol Biomed Life Sci· May 2002

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Disposition of the selective cholesterol absorption inhibitor ezetimibe in healthy male subjects.
James E Patrick, Teddy Kosoglou, Kathe L Stauber, Kevin B Alton, Stephen E Maxwell

Drug Metab Dispos· April 2002

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